Search Results - "Roth, Robert G"

MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes by Baens, Mathijs, Bonsignore, Luca, Somers, Riet, Vanderheydt, Charlotte, Weeks, Stephen D, Gunnarsson, Jenny, Nilsson, Ewa, Roth, Robert G, Thome, Margot, Marynen, Peter

“…Mucosa-associated lymphoid tissue 1 (MALT1) controls antigen receptor-mediated signalling to nuclear factor κB (NF-κB) through both its adaptor and protease…”
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Use of a protein engineering strategy to overcome limitations in the production of “Difficult to Express” recombinant proteins by Hussain, Hirra, Fisher, David I., Abbott, W. Mark, Roth, Robert G., Dickson, Alan J.

“…ABSTRACT Certain recombinant proteins are deemed “difficult to express” in mammalian expression systems requiring significant cell and/or process engineering…”
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Protein Expression via Transient Transfection of Mammalian Cells in a WAVE Bioreactor by Gunnarsson, Jenny, Fisher, David I, Roth, Robert G

“…Large culture volumes are often required when expression constructs are particularly low-yielding or when end uses require significant amounts of material. In…”
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Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins by Malm, Magdalena, Kuo, Chih-Chung, Barzadd, Mona Moradi, Mebrahtu, Aman, Wistbacka, Num, Razavi, Ronia, Volk, Anna-Luisa, Lundqvist, Magnus, Kotol, David, Tegel, Hanna, Hober, Sophia, Edfors, Fredrik, Gräslund, Torbjörn, Chotteau, Veronique, Field, Ray, Varley, Paul G., Roth, Robert G., Lewis, Nathan E., Hatton, Diane, Rockberg, Johan

“…Biologics represent the fastest growing group of therapeutics, but many advanced recombinant protein moieties remain difficult to produce. Here, we identify…”
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A protein chimera strategy supports production of a model “difficult‐to‐express” recombinant target by Hussain, Hirra, Fisher, David I., Roth, Robert G., Mark Abbott, W., Carballo‐Amador, Manuel Alejandro, Warwicker, Jim, Dickson, Alan J.

“…Due in part to the needs of the biopharmaceutical industry, there has been an increased drive to generate high quality recombinant proteins in large amounts…”
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Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling by Sandmark, Jenny, Dahl, Göran, Öster, Linda, Xu, Bingze, Johansson, Patrik, Akerud, Tomas, Aagaard, Anna, Davidsson, Pia, Bigalke, Janna M., Winzell, Maria Sörhede, Rainey, G. Jonah, Roth, Robert G.

“…Neurturin (NRTN) provides trophic support to neurons and is considered a therapeutic agent for neurodegenerative diseases, such as Parkinson’s disease. It…”
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Systematic Evaluation of CRISPRa and CRISPRi Modalities Enables Development of a Multiplexed, Orthogonal Gene Activation and Repression System by Martella, Andrea, Firth, Mike, Taylor, Benjamin J. M, Göppert, Anne, Cuomo, Emanuela M, Roth, Robert G, Dickson, Alan J, Fisher, David I

“…The ability to manipulate the expression of mammalian genes using synthetic transcription factors is highly desirable in both fields of basic research and…”
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Systematic evaluation of SARS‐CoV‐2 antigens enables a highly specific and sensitive multiplex serological COVID‐19 assay by Hober, Sophia, Hellström, Cecilia, Olofsson, Jennie, Andersson, Eni, Bergström, Sofia, Jernbom Falk, August, Bayati, Shaghayegh, Mravinacova, Sara, Sjöberg, Ronald, Yousef, Jamil, Skoglund, Lovisa, Kanje, Sara, Berling, Anna, Svensson, Anne‐Sophie, Jensen, Gabriella, Enstedt, Henric, Afshari, Delaram, Xu, Lan Lan, Zwahlen, Martin, Feilitzen, Kalle, Hanke, Leo, Murrell, Ben, McInerney, Gerald, Karlsson Hedestam, Gunilla B, Lendel, Christofer, Roth, Robert G, Skoog, Ingmar, Svenungsson, Elisabet, Olsson, Tomas, Fogdell‐Hahn, Anna, Lindroth, Ylva, Lundgren, Maria, Maleki, Kimia T, Lagerqvist, Nina, Klingström, Jonas, Da Silva Rodrigues, Rui, Muschiol, Sandra, Bogdanovic, Gordana, Arroyo Mühr, Laila Sara, Eklund, Carina, Lagheden, Camilla, Dillner, Joakim, Sivertsson, Åsa, Havervall, Sebastian, Thålin, Charlotte, Tegel, Hanna, Pin, Elisa, Månberg, Anna, Hedhammar, My, Nilsson, Peter

“…Objective The COVID‐19 pandemic poses an immense need for accurate, sensitive and high‐throughput clinical tests, and serological assays are needed for both…”
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Discovery of a Series of Indole‑2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2‑X) Inhibitors by Knerr, Laurent, Giordanetto, Fabrizio, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Olsson, Thomas, Perkins, Tim D. J., Herslöf, Margareta, Månsson, Åsa, Dahlström, Mikael, Starke, Ingemar, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Brengdahl, Johan, Jansen, Frank, Rohman, Mattias, Sandmark, Jenny, Hallberg, Kenth, Åkerud, Tomas, Roth, Robert G., Ahlqvist, Marie

“…In order to assess the potential of sPLA2-X as a therapeutic target for atherosclerosis, novel sPLA2 inhibitors with improved type X selectivity are required…”
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Design of Selective sPLA2‑X Inhibitor (−)-2-{2-[Carbamoyl-6-(trifluoromethoxy)‑1H‑indol-1-yl]pyridine-2-yl}propanoic Acid by Giordanetto, Fabrizio, Knerr, Laurent, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Månsson, Åsa, Dahlström, Mikael, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Wikström, Johannes, Wågberg, Maria, Brengdahl, Johan, Rohman, Mattias, Sandmark, Jenny, Åkerud, Tomas, Roth, Robert G., Jansen, Frank, Ahlqvist, Marie

“…A lead generation campaign identified indole-based sPLA2-X inhibitors with a promising selectivity profile against other sPLA2 isoforms. Further optimization…”
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Design of Selective sPLA 2 -X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1 H -indol-1-yl]pyridine-2-yl}propanoic Acid by Giordanetto, Fabrizio, Knerr, Laurent, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Månsson, Åsa, Dahlström, Mikael, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Wikström, Johannes, Wågberg, Maria, Brengdahl, Johan, Rohman, Mattias, Sandmark, Jenny, Åkerud, Tomas, Roth, Robert G, Jansen, Frank, Ahlqvist, Marie

“…A lead generation campaign identified indole-based sPLA -X inhibitors with a promising selectivity profile against other sPLA isoforms. Further optimization of…”
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Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A 2 Type X (sPLA 2 -X) Inhibitors by Knerr, Laurent, Giordanetto, Fabrizio, Nordberg, Peter, Pettersen, Daniel, Selmi, Nidhal, Beisel, Hans-Georg, de la Motte, Hannah, Olsson, Thomas, Perkins, Tim D J, Herslöf, Margareta, Månsson, Åsa, Dahlström, Mikael, Starke, Ingemar, Broddefalk, Johan, Saarinen, Gabrielle, Klingegård, Fredrik, Hurt-Camejo, Eva, Rosengren, Birgitta, Brengdahl, Johan, Jansen, Frank, Rohman, Mattias, Sandmark, Jenny, Hallberg, Kenth, Åkerud, Tomas, Roth, Robert G, Ahlqvist, Marie

“…In order to assess the potential of sPLA -X as a therapeutic target for atherosclerosis, novel sPLA inhibitors with improved type X selectivity are required…”
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The Evolving Audience: Alternatives to Audience Accommodation by Roth, Robert G.

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MALT1 Auto-Proteolysis Is Essential for NF- Kappa B-Dependent Gene Transcription in Activated Lymphocytes: e103774 by Baens, Mathijs, Bonsignore, Luca, Somers, Riet, Vanderheydt, Charlotte, Weeks, Stephen D, Gunnarsson, Jenny, Nilsson, Ewa, Roth, Robert G, Thome, Margot, Marynen, Peter

“…Mucosa-associated lymphoid tissue 1 (MALT1) controls antigen receptor-mediated signalling to nuclear factor Kappa B (NF- Kappa B) through both its adaptor and…”
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Surgical Treatment of Extracranial Arterial Occlusion by Roth, Robert G

“…To the Editor.—The Joint Study of Extracranial Arterial Occlusion (211:1993, 1970) provided valuable data comparing the results of carotid surgical and…”
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Hypokalemic myopathy with myoglobinuria associated with licorice ingestion by Gross, E G, Dexter, J D, Roth, R G

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Organic Phosphorus Compounds. IV.1 A Study of the Transesterification of Dialkyl Alkylphosphonites by Hoffmann, Friedrich W, Roth, Robert G, Simmons, Thomas C

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The Evolving Audience: Alternatives to Audience Accommodation by Roth, Robert G.

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The Evolving Audience: Alternatives to Audience Accommodation by Roth, Robert G

“…Discusses the possibility that a writer's audience may be more malleable than it is normally assumed to be and describes how one researcher worked with several…”
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Organic Phosphorus Compounds. IV. 1 A Study of the Transesterification of Dialkyl Alkylphosphonites by Hoffmann, Friedrich W., Roth, Robert G., Simmons, Thomas C.

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