Search Results - "Roth, Richard B."
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Evaluation of Alere i Influenza A&B for rapid detection of influenza viruses A and B
Published in Journal of clinical microbiology (01-09-2014)“…Rapid and accurate diagnosis of influenza is important for infection control, as well as for patient management. Alere i Influenza A&B is an isothermal nucleic…”
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Human Endometriosis Is Associated with Plasma Cells and Overexpression of B Lymphocyte Stimulator
Published in Proceedings of the National Academy of Sciences - PNAS (24-07-2007)“…Endometriosis affects 10-20% of women of reproductive age and is associated with pelvic pain and infertility, and its pathogenesis is not well understood. We…”
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3
Role of ICAM1 in invasion of human breast cancer cells
Published in Carcinogenesis (New York) (01-05-2005)“…We identified previously a region on chromosome 19p13.2 spanning the genes encoding the intercellular adhesion molecules (ICAM), ICAM1, ICAM4 and ICAM5 as a…”
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4
Association of the PDCD5 Locus With Lung Cancer Risk and Prognosis in Smokers
Published in Journal of clinical oncology (10-04-2006)“…Whole-genome scan association analysis was carried out to identify genetic variants predictive of lung cancer risk in smokers and to confirm the identified…”
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5
Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells
Published in Molecular cancer therapeutics (01-03-2005)“…A genome-wide case-control association study done in our laboratory has identified a single nucleotide polymorphism located in RAD21 as being significantly…”
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Association of the NuMA Region on Chromosome 11q13 with Breast Cancer Susceptibility
Published in Proceedings of the National Academy of Sciences - PNAS (08-02-2005)“…The development of breast cancer is a complex process that involves multiple genes at many stages, from initial cell cycle dysregulation to disease…”
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Gene expression analyses reveal molecular relationships among 20 regions of the human CNS
Published in Neurogenetics (01-05-2006)“…Transcriptional profiling was performed to survey the global expression patterns of 20 anatomically distinct sites of the human central nervous system (CNS)…”
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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
Published in The Journal of clinical investigation (01-12-2003)“…Chronic infection and associated inflammation are key contributors to human carcinogenesis. Ulcerative colitis (UC) is an oxyradical overload disease and is…”
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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
Published in The Journal of clinical investigation (15-12-2003)“…Chronic infection and associated inflammation are key contributors to human carcinogenesis. Ulcerative colitis (UC) is an oxyradical overload disease and is…”
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10
3-Methyladenine DNA glycosylase-deficient Aag null mice display unexpected bone marrow alkylation resistance
Published in Cancer research (Chicago, Ill.) (01-02-2002)“…Most cells deficient in 3-methyladenine (3MeA) DNA glycosylase become sensitive to the lethal and clastogenic effects of alkylating agents. Surprisingly,…”
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Large-scale association study identifies ICAM gene region as breast and prostate cancer susceptibility locus
Published in Cancer research (Chicago, Ill.) (15-12-2004)“…We conducted a large-scale association study to identify genes that influence nonfamilial breast cancer risk using a collection of German cases and matched…”
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12
BRAF Polymorphisms and Risk of Melanocytic Neoplasia
Published in Journal of investigative dermatology (01-12-2005)“…Somatic mutations of the BRAF gene are common in melanomas and nevi but the contribution of polymorphisms in this gene to melanoma or nevus susceptibility…”
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13
DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents
Published in Mutagenesis (01-05-1999)“…We have generated mice deficient in O6-methylguanine DNA methyltransferase activity encoded by the murine Mgmt gene using homologous recombination to delete…”
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14
Genetic polymorphisms in DPF3 associated with risk of breast cancer and lymph node metastases
Published in Journal of carcinogenesis (19-08-2005)“…Several studies have identified rare genetic variations responsible for many cases of familial breast cancer but their contribution to total breast cancer…”
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15
Gene transfer to suppress bone marrow alkylation sensitivity
Published in Mutation research (01-04-2000)“…Alkylating agents represent a highly cytotoxic class of chemotherapeutic compounds that are extremely effective anti-tumor agents. Unfortunately, alkylating…”
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Bacteriophage T7 RNA Polymerase Transcription Elongation Is Inhibited by Site-Specific, Stereospecific Benzo[c]phenanthrene Diol Epoxide DNA Lesions
Published in Biochemistry (Easton) (01-05-2001)“…Benzo[c]phenanthrene diol epoxide (B[c]PhDE), the ultimate carcinogenic metabolite of the environmental pollutant benzo[c]phenanthrene, reacts with DNA…”
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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
Published in The Journal of clinical investigation (01-02-2004)Get full text
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The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation
Published in The Journal of clinical investigation (01-02-2004)Get full text
Journal Article -
19
Incorrect Base Insertion and Prematurely Terminated Transcripts during T7 RNA Polymerase Transcription Elongation past Benzo[ a]pyrenediol Epoxide-modified DNA
Published in Journal of molecular biology (29-11-1996)“…DNA replication and transcription are affected adversely by the presence of bulky adducts that are generated by the covalent binding of a variety of…”
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T7 RNA polymerase transcription past site-specific, stereospecific, benzo(c)phenanthrene diolepoxide DNA lesions
Published 01-01-1997“…Benzo (c) phenanthrene, a byproduct of fossil fuel combustion, can be biotransformed into the ultimate carcinogen benzo (c) phenanthrene diolepoxide (B (c)…”
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