Search Results - "Roth, Rachel J."

The Conserved Misshapen-Warts-Yorkie Pathway Acts in Enteroblasts to Regulate Intestinal Stem Cells in Drosophila by Li, Qi, Li, Shuangxi, Mana-Capelli, Sebastian, Roth Flach, Rachel J., Danai, Laura V., Amcheslavsky, Alla, Nie, Yingchao, Kaneko, Satoshi, Yao, Xiaohao, Chen, Xiaochu, Cotton, Jennifer L., Mao, Junhao, McCollum, Dannel, Jiang, Jin, Czech, Michael P., Xu, Lan, Ip, Y. Tony

“…Similar to the mammalian intestine, the Drosophila adult midgut has resident stem cells that support growth and regeneration. How the niche regulates…”
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An assessment of thermoneutral housing conditions on murine cardiometabolic function by Chen, Xian, Bollinger, Eliza, Cunio, Teresa, Damilano, Federico, Stansfield, John C, Pinkus, Cynthia A, Kreuser, Steven, Hirenallur-Shanthappa, Dinesh, Roth Flach, Rachel J

“…Mouse models are used to model human diseases and perform pharmacological efficacy testing to advance therapies to humans; most of these studies are conducted…”
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IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis by Negrin, Kimberly A, Roth Flach, Rachel J, DiStefano, Marina T, Matevossian, Anouch, Friedline, Randall H, Jung, DaeYoung, Kim, Jason K, Czech, Michael P

“…Non-alcoholic fatty liver disease is prevalent in human obesity and type 2 diabetes, and is characterized by increases in both hepatic triglyceride…”
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Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition by Roth Flach, Rachel J, Su, Chunyan, Bollinger, Eliza, Cortes, Christian, Robertson, Andrew W, Opsahl, Alan C, Coskran, Timothy M, Maresca, Kevin P, Keliher, Edmund J, Yates, Phillip D, Kim, Albert M, Kalgutkar, Amit S, Buckbinder, Leonard

“…Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are…”
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Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis by Roth Flach, Rachel J., Skoura, Athanasia, Matevossian, Anouch, Danai, Laura V., Zheng, Wei, Cortes, Christian, Bhattacharya, Samit K., Aouadi, Myriam, Hagan, Nana, Yawe, Joseph C., Vangala, Pranitha, Menendez, Lorena Garcia, Cooper, Marcus P., Fitzgibbons, Timothy P., Buckbinder, Leonard, Czech, Michael P.

“…Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and inflammation are pivotal for atherosclerosis initiation and…”
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Mixed meal tolerance testing highlights in diabetes altered branched-chain ketoacid metabolism and pathways associated with all-cause mortality by Mi, Michael Y., Whitlock, Mark, Shi, Xu, Farrell, Laurie A., Bhambhani, Victoria M., Quadir, Juweria, Blatnik, Matthew, Wald, Kyle P., Tierney, Brendan, Kim, Albert, Loudon, Peter, Chen, Zsu-Zsu, Correa, Adolfo, Gao, Yan, Carson, April P., Bertoni, Alain G., Roth Flach, Rachel J., Gerszten, Robert E.

“…Elevated BCAA levels are strongly associated with diabetes, but how diabetes affects BCAA, branched-chain ketoacids (BCKAs), and the broader metabolome after a…”
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Hepatic Mitogen-Activated Protein Kinase Phosphatase 1 Selectively Regulates Glucose Metabolism and Energy Homeostasis by Lawan, Ahmed, Zhang, Lei, Gatzke, Florian, Min, Kisuk, Jurczak, Michael J., Al-Mutairi, Mashael, Richter, Patric, Camporez, Joao Paulo G., Couvillon, Anthony, Pesta, Dominik, Roth Flach, Rachel J., Shulman, Gerald I., Bennett, Anton M.

“…The liver plays a critical role in glucose metabolism and communicates with peripheral tissues to maintain energy homeostasis. Obesity and insulin resistance…”
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Small molecule branched-chain ketoacid dehydrogenase kinase (BDK) inhibitors with opposing effects on BDK protein levels by Roth Flach, Rachel J., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Kormos, Bethany L., Liu, Shenping, Reese, Matthew R., Martinez Alsina, Luis A., Buzon, Leanne, Zhang, Yuan, Bechle, Bruce, Rosado, Amy, Sahasrabudhe, Parag V., Knafels, John, Bhattacharya, Samit K., Omoto, Kiyoyuki, Stansfield, John C., Hurley, Liam D., Song, LouJin, Luo, Lina, Breitkopf, Susanne B., Monetti, Mara, Cunio, Teresa, Tierney, Brendan, Geoly, Frank J., Delmore, Jake, Siddall, C. Parker, Xue, Liang, Yip, Ka N., Kalgutkar, Amit S., Miller, Russell A., Zhang, Bei B., Filipski, Kevin J.

“…Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the…”
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Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion by Senol-Cosar, Ozlem, Flach, Rachel J. Roth, DiStefano, Marina, Chawla, Anil, Nicoloro, Sarah, Straubhaar, Juerg, Hardy, Olga T., Noh, Hye Lim, Kim, Jason K., Wabitsch, Martin, Scherer, Philipp E., Czech, Michael P.

“…Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been…”
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Dynamic Regulation of Pro- and Anti-Inflammatory Cytokines by MAPK Phosphatase 1 (MKP-1) in Innate Immune Responses by Chi, Hongbo, Barry, Sean P., Roth, Rachel J., Wu, J. Julie, Jones, Elizabeth A., Bennett, Anton M., Flavell, Richard A.

“…Engagement of Toll-like receptors (TLRs) on macrophages leads to activation of the mitogen-activated protein kinases (MAPKs), which contribute to innate immune…”
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Targeting lymphatic function in cardiovascular-kidney-metabolic syndrome: preclinical methods to analyze lymphatic function and therapeutic opportunities by Fowler, Joseph Wayne M, Song, LouJin, Tam, Kelly, Roth Flach, Rachel J

“…The lymphatic vascular system spans nearly every organ in the body and serves as an important network that maintains fluid, metabolite, and immune cell…”
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BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice by Bollinger, Eliza, Peloquin, Matthew, Libera, Jenna, Albuquerque, Bina, Pashos, Evanthia, Shipstone, Arun, Hadjipanayis, Angela, Sun, Zhongyuan, Xing, Gang, Clasquin, Michelle, Stansfield, John C., Tierney, Brendan, Gernhardt, Steven, Siddall, C. Parker, Greizer, Timothy, Geoly, Frank J., Vargas, Sarah R., Gao, Lily C., Williams, George, Marshall, Mackenzie, Rosado, Amy, Steppan, Claire, Filipski, Kevin J., Zhang, Bei B., Miller, Russell A., Roth Flach, Rachel J.

“…Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how…”
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β3-Adrenergic Receptor Stimulation Induces E-Selectin-mediated Adipose Tissue Inflammation by Roth Flach, Rachel J., Matevossian, Anouch, Akie, Thomas E., Negrin, Kimberly A., Paul, Marina T., Czech, Michael P.

“…Inflammation induced by wound healing or infection activates local vascular endothelial cells to mediate leukocyte rolling, adhesion, and extravasation by…”
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Identification of Map4k4 as a Novel Suppressor of Skeletal Muscle Differentiation by Wang, Mengxi, Amano, Shinya U., Flach, Rachel J. Roth, Chawla, Anil, Aouadi, Myriam, Czech, Michael P.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of Mitogen-activated Protein Kinase Phosphatase-1 Protects from Hepatic Steatosis by Repression of Cell Death-inducing DNA Fragmentation Factor A (DFFA)-like Effector C (CIDEC)/Fat-specific Protein 27 by Flach, Rachel J. Roth, Qin, Hui, Zhang, Lei, Bennett, Anton M.

“…The integration of metabolic signals required for the regulation of hepatic lipid homeostasis is complex. Previously, we showed that mice lacking expression of…”
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Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension by Song, LouJin, Chen, Xian, Swanson, Terri A, LaViolette, Brianna, Pang, Jincheng, Cunio, Teresa, Nagle, Michael W, Asano, Shoh, Hales, Katherine, Shipstone, Arun, Sobon, Hanna, Al-Harthy, Sabra D, Ahn, Youngwook, Kreuser, Steven, Robertson, Andrew, Ritenour, Casey, Voigt, Frank, Boucher, Magalie, Sun, Furong, Sessa, William C, Roth Flach, Rachel J

“…The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little is known about its role in chronic cardiac dysfunction. Here,…”
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Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity by Wu, J. Julie, Roth, Rachel J., Anderson, Ethan J., Hong, Eun-Gyoung, Lee, Mi-Kyung, Choi, Cheol Soo, Neufer, P. Darrell, Shulman, Gerald I., Kim, Jason K., Bennett, Anton M.

“…The mitogen-activated protein kinases (MAPK) play critical roles in the pathogenesis of diabetes and obesity. The MAPKs are inactivated by MAPK phosphatases…”
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Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance by DiStefano, Marina T, Roth Flach, Rachel J, Senol-Cosar, Ozlem, Danai, Laura V, Virbasius, Joseph V, Nicoloro, Sarah M, Straubhaar, Juerg, Dagdeviren, Sezin, Wabitsch, Martin, Gupta, Olga T, Kim, Jason K, Czech, Michael P

“…Abstract Objective Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism…”
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NETs and traps delay wound healing in diabetes by Roth Flach, Rachel J, Czech, Michael P

“…Diabetes is associated with dire peripheral sequelae including foot ulcers and amputations. A recent article by Wong et al . demystifies this connection by…”
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Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues by Danai, Laura V., Roth Flach, Rachel J., Virbasius, Joseph V., Garcia Menendez, Lorena, Jung, Dae Young, Kim, Jong Hun, Kim, Jason K., Czech, Michael P.

“…Studies in vitro suggest that mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) attenuates insulin signaling, but confirmation in vivo is…”
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