Search Results - "Roth, RA"

Intrinsic versus idiosyncratic drug-induced hepatotoxicity--two villains or one? by Roth, Robert A, Ganey, Patricia E

“…"Intrinsic" and "idiosyncratic" drug-induced liver injury reactions are commonly thought to arise by different modes of action. Intrinsic toxicity is…”
Get more information

Inhibition of mTOR Activity Restores Tamoxifen Response in Breast Cancer Cells with Aberrant Akt Activity by DEGRAFFENRIED, Linda A, FRIEDRICHS, William E, RUSSELL, Douglas H, DONZIS, Elissa J, MIDDLETON, Amanda K, SILVA, Jessica M, ROTH, Richard A, HIDALGO, Manuel

“…The Akt kinase is a serine/threonine protein kinase that has been implicated in mediating a variety of biological responses. Studies show that high Akt…”
Get full text

Calcium Contributes to the Cytotoxic Interaction Between Diclofenac and Cytokines by Maiuri, Ashley R, Breier, Anna B, Turkus, Jonathan D, Ganey, Patricia E, Roth, Robert A

“…Diclofenac (DCLF) is a widely used non-steroidal anti-inflammatory drug that is associated with idiosyncratic, drug-induced liver injury (IDILI) in humans. The…”
Get full text

Neutrophil Migration Mechanisms, with an Emphasis on the Pulmonary Vasculature by Wagner, J G, Roth, R A

“…Leukocyte trafficking into pulmonary tissue and airspaces is a critical component of the host defense response. Activation and migration of polymorphonuclear…”
Get full text

Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2 by Liu, Hong, Radisky, Derek C, Nelson, Celeste M, Zhang, Hui, Fata, Jimmie E, Roth, Richard A, Bissell, Mina J

“…Akt1 is frequently up-regulated in human tumors and has been shown to accelerate cell proliferation and to suppress programmed cell death; consequently,…”
Get full text

Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner by Kovacina, Kristina S, Park, Grace Y, Bae, Sun Sik, Guzzetta, Andrew W, Schaefer, Erik, Birnbaum, Morris J, Roth, Richard A

“…Akt (also called protein kinase B) is one of the major downstream targets of the phosphatidylinositol 3-kinase pathway. This protein kinase has been implicated…”
Get full text

Role of the coagulation system in acetaminophen‐induced hepatotoxicity in mice by Ganey, Patricia E., Luyendyk, James P., Newport, Sandra W., Eagle, Theresa M., Maddox, Jane F., Mackman, Nigel, Roth, Robert A.

“…Acetaminophen (N‐acetyl‐p‐aminophenol [APAP]) is one of the leading causes of acute liver failure, and APAP hepatotoxicity is associated with coagulopathy in…”
Get full text

Stimulation of Lipolysis and Hormone-sensitive Lipase via the Extracellular Signal-regulated Kinase Pathway by Greenberg, A S, Shen, W J, Muliro, K, Patel, S, Souza, S C, Roth, R A, Kraemer, F B

“…Hormonally stimulated lipolysis occurs by activation of cyclic AMP-dependent protein kinase (PKA) which phosphorylates hormone-sensitive lipase (HSL) and…”
Get full text

Inorganic Polyphosphate Stimulates Mammalian TOR, a Kinase Involved in the Proliferation of Mammary Cancer Cells by Wang, Lihong, Fraley, Cresson D., Faridi, Jesika, Kornberg, Arthur, Roth, Richard A.

“…Inorganic polyphosphate (poly P), chains of hundreds of phosphate residues linked by "high-energy" bonds as in ATP, has been conserved from prebiotic times in…”
Get full text

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines by Nakatani, Kaname, Thompson, Devon A., Barthel, Andreas, Sakaue, Hiroshi, Liu, Wei, Weigel, Ronald J., Roth, Richard A.

“…We measured the insulin-stimulated amount of Akt1, Akt2, and Akt3 enzymatic activities in four breast cancer cell lines and three prostate cancer cell lines…”
Get full text

Microarray analysis of lipopolysaccharide potentiation of trovafloxacin-induced liver injury in rats suggests a role for proinflammatory chemokines and neutrophils by Waring, Jeffrey F, Liguori, Michael J, Luyendyk, James P, Maddox, Jane F, Ganey, Patricia E, Stachlewitz, Robert F, North, Colin, Blomme, Eric A G, Roth, Robert A

“…Idiosyncratic drug toxicity refers to toxic reactions occurring in a small subset of patients and usually cannot be predicted during preclinical or early…”
Get more information

Inflammation and drug idiosyncrasy--is there a connection? by Roth, Robert A, Luyendyk, James P, Maddox, Jane F, Ganey, Patricia E

“…"Drug idiosyncrasy" refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of…”
Get more information

Modulation of Insulin-stimulated Degradation of Human Insulin Receptor Substrate-1 by Serine 312 Phosphorylation by Greene, Michael W, Sakaue, Hiroshi, Wang, Lihong, Alessi, Dario R, Roth, Richard A

“…Ser/Thr phosphorylation of insulin receptor substrate-1 (IRS-1) is a negative regulator of insulin signaling. One potential mechanism for this is that Ser/Thr…”
Get full text

Monocrotaline pyrrole‐induced changes in angiotensin‐converting enzyme activity of cultured pulmonary artery endothelial cells by Hoorn, Cindy M., Roth, Robert A.

“…1 Changes in the structural and functional integrity of endothelium have been recognized as relatively early features of delayed and progressive pulmonary…”
Get full text

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation by Kohn, Aimee D., Summers, Scott A., Birnbaum, Morris J., Roth, Richard A.

“…Akt is a serine/threonine kinase that requires a functional phosphatidylinositol 3-kinase to be stimulated by insulin and other growth factors. When directed…”
Get full text

Modulation of Insulin Receptor Substrate-1 Tyrosine Phosphorylation and Function by Mitogen-activated Protein Kinase by De Fea, Kathryn, Roth, Richard A.

“…Increased serine phosphorylation of insulin receptor substrate-1 (IRS-1) has been observed in several systems to correlate with a decreased ability of the…”
Get full text

Adverse hepatic drug reactions: inflammatory episodes as consequence and contributor by Ganey, Patricia E., Luyendyk, James P., Maddox, Jane F., Roth, Robert A.

“…Susceptibility to drug toxicity is influenced by a variety of factors, both genetic and environmental. The focus of this article is the evidence addressing the…”
Get full text

Evidence of Insulin-Stimulated Phosphorylation and Activation of the Mammalian Target of Rapamycin Mediated by a Protein Kinase B Signaling Pathway by Scott, Pamela H., Brunn, Gregory J., Kohn, Aimee D., Roth, Richard A., Lawrence, John C.

“…The effects of insulin on the mammalian target of rapamycin, mTOR, were investigated in 3T3-L1 adipocytes. mTOR protein kinase activity was measured in immune…”
Get full text

Akt, a Pleckstrin Homology Domain Containing Kinase, Is Activated Primarily by Phosphorylation by Kohn, A D, Takeuchi, F, Roth, R A

“…Akt is a serine/threonine kinase that is stimulated by receptor tyrosine kinases and contains a pleckstrin homology domain. One model proposed to explain this…”
Get full text

Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats by Luyendyk, James P, Maddox, Jane F, Cosma, Gregory N, Ganey, Patricia E, Cockerell, Gary L, Roth, Robert A

“…Drug idiosyncrasy is an adverse event of unknown etiology that occurs in a small fraction of people taking a drug. Some idiosyncratic drug reactions may occur…”
Get more information