Search Results - "Roth, Patrick"

The network of immunosuppressive pathways in glioblastoma by Mangani, Davide, Weller, Michael, Roth, Patrick

“…[Display omitted] Glioblastoma remains a fatal tumor despite increased knowledge regarding the complex signalling pathways that drive this devastating disease…”
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Biological activity of tumor-treating fields in preclinical glioma models by Silginer, Manuela, Weller, Michael, Stupp, Roger, Roth, Patrick

“…Glioblastoma is the most common and aggressive form of intrinsic brain tumor with a very poor prognosis. Thus, novel therapeutic approaches are urgently…”
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EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood by Weller, Michael, van den Bent, Martin, Preusser, Matthias, Le Rhun, Emilie, Tonn, Jörg C., Minniti, Giuseppe, Bendszus, Martin, Balana, Carmen, Chinot, Olivier, Dirven, Linda, French, Pim, Hegi, Monika E., Jakola, Asgeir S., Platten, Michael, Roth, Patrick, Rudà, Roberta, Short, Susan, Smits, Marion, Taphoorn, Martin J. B., von Deimling, Andreas, Westphal, Manfred, Soffietti, Riccardo, Reifenberger, Guido, Wick, Wolfgang

“…In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of…”
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EANO guidelines for the diagnosis and treatment of ependymal tumors by Rudà, Roberta, Reifenberger, Guido, Frappaz, Didier, Pfister, Stefan M, Laprie, Anne, Santarius, Thomas, Roth, Patrick, Tonn, Joerg Christian, Soffietti, Riccardo, Weller, Michael, Moyal, Elizabeth Cohen-Jonathan

“…Ependymal tumors are rare CNS tumors and may occur at any age, but their proportion among primary brain tumors is highest in children and young adults. Thus,…”
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Structure and mechanism of a phosphotransferase system glucose transporter by Roth, Patrick, Jeckelmann, Jean-Marc, Fender, Inken, Ucurum, Zöhre, Lemmin, Thomas, Fotiadis, Dimitrios

“…Glucose is the primary source of energy for many organisms and is efficiently taken up by bacteria through a dedicated transport system that exhibits high…”
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Chemotherapy sensitization of glioblastoma by focused ultrasound-mediated delivery of therapeutic liposomes by Papachristodoulou, Alexandros, Signorell, Rea Deborah, Werner, Beat, Brambilla, Davide, Luciani, Paola, Cavusoglu, Mustafa, Grandjean, Joanes, Silginer, Manuela, Rudin, Markus, Martin, Ernst, Weller, Michael, Roth, Patrick, Leroux, Jean-Christophe

“…In glioblastoma, the benefit from temozolomide chemotherapy is largely limited to a subgroup of patients (30–35%) with tumors exhibiting methylation of the…”
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Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma by Happold, Caroline, Gorlia, Thierry, Chinot, Olivier, Gilbert, Mark R, Nabors, L Burt, Wick, Wolfgang, Pugh, Stephanie L, Hegi, Monika, Cloughesy, Timothy, Roth, Patrick, Reardon, David A, Perry, James R, Mehta, Minesh P, Stupp, Roger, Weller, Michael

“…Symptomatic epilepsy is a common complication of glioblastoma and requires pharmacotherapy. Several uncontrolled retrospective case series and a post hoc…”
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Autocrine activation of the IFN signaling pathway may promote immune escape in glioblastoma by Silginer, Manuela, Nagy, Sara, Happold, Caroline, Schneider, Hannah, Weller, Michael, Roth, Patrick

“…Interferons (IFNs) are cytokines typically induced upon viral infection but are constitutively expressed also in the absence of acute infection. The…”
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European Association of Neuro-Oncology (EANO) guidelines for treatment of primary central nervous system lymphoma (PCNSL) by Hoang-Xuan, Khê, Deckert, Martina, Ferreri, Andrés J M, Furtner, Julia, Gallego Perez-Larraya, Jaime, Henriksson, Roger, Hottinger, Andreas F, Kasenda, Benjamin, Lefranc, Florence, Lossos, Alexander, McBain, Catherine, Preusser, Matthias, Roth, Patrick, Rudà, Roberta, Schlegel, Uwe, Soffietti, Riccardo, Soussain, Carole, Taphoorn, Martin J B, Touitou, Valérie, Weller, Michael, Bromberg, Jacoline E C

“…The management of primary central nervous system (PCNSL) is one of the most controversial topics in neuro-oncology because of the complexity of the disease and…”
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Differential roles of type I interferon signaling in tumor versus host cells in experimental glioma models by Blomberg, Evelina, Silginer, Manuela, Roth, Patrick, Weller, Michael

“…•IFNAR1 knockout decreased proliferation in vitro in SMA-560 and GL-261 glioma cells.•GL-261 was the only model demonstrating constitutive type 1 IFN…”
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Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cells by Happold, Caroline, Roth, Patrick, Wick, Wolfgang, Schmidt, Natalie, Florea, Ana-Maria, Silginer, Manuela, Reifenberger, Guido, Weller, Michael

“…J. Neurochem. (2012) 122, 444–455. Temozolomide (TMZ) is an alkylating chemotherapeutic agent that prolongs the survival of patients with glioblastoma…”
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The RANO Leptomeningeal Metastasis Group proposal to assess response to treatment: lack of feasibility and clinical utility and a revised proposal by Le Rhun, Emilie, Devos, Patrick, Boulanger, Thomas, Smits, Marion, Brandsma, Dieta, Rudà, Roberta, Furtner, Julia, Hempel, Johann-Martin, Postma, Tjeerd J, Roth, Patrick, Snijders, Tom J, Winkler, Frank, Winklhofer, Sebastian, Castellano, Antonella, Hattingen, Elke, Capellades, Jaume, Gorlia, Thierry, Van den Bent, Martin, Wen, Patrick Y, Bendszus, Martin, Weller, Michael

“…A scorecard to evaluate magnetic resonance imaging (MRI) findings during the course of leptomeningeal metastases (LM) has been proposed by the Response…”
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Realistic Assessment of Research Publications by Neurosurgery Residency Applicants by Hasley, Hunter L., O'Malley, Geoffrey R., Bala, Suraj, Weisman, Hannah E., Roth, Patrick A.

“…Neurosurgical residency applicants' prior research experience can amplify their ability to stand out to prospective neurosurgery programs. We attempted to…”
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A specific miRNA signature in the peripheral blood of glioblastoma patients by Roth, Patrick, Wischhusen, Jörg, Happold, Caroline, Chandran, P. Anoop, Hofer, Silvia, Eisele, Günter, Weller, Michael, Keller, Andreas

“…J. Neurochem. (2011) 118, 449–457. The prognosis of patients afflicted by glioblastoma remains poor. Biomarkers for the disease would be desirable in order to…”
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Predictors of failure in infants with viral bronchiolitis treated with high-flow, high-humidity nasal cannula therapy by Abboud, Patricia A, Roth, Patrick J, Skiles, Cheryl L, Stolfi, Adrienne, Rowin, Mark E

“…Viral bronchiolitis is an acute infection and inflammatory disease of the respiratory tract, with infants typically presenting with the most severe symptoms…”
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Neurolymphomatosis: an International Primary CNS Lymphoma Collaborative Group report by Grisariu, Sigal, Avni, Batia, Batchelor, Tracy T., van den Bent, Martin J., Bokstein, Felix, Schiff, David, Kuittinen, Outi, Chamberlain, Marc C., Roth, Patrick, Nemets, Anatoly, Shalom, Edna, Ben-Yehuda, Dina, Siegal, Tali

“…Neurolymphomatosis (NL) is a rare clinical entity. The International Primary CNS Lymphoma Collaborative Group retrospectively analyzed 50 patients assembled…”
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High‐throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification by Zhu, Yi, Weiss, Tobias, Zhang, Qiushi, Sun, Rui, Wang, Bo, Yi, Xiao, Wu, Zhicheng, Gao, Huanhuan, Cai, Xue, Ruan, Guan, Zhu, Tiansheng, Xu, Chao, Lou, Sai, Yu, Xiaoyan, Gillet, Ludovic, Blattmann, Peter, Saba, Karim, Fankhauser, Christian D., Schmid, Michael B., Rutishauser, Dorothea, Ljubicic, Jelena, Christiansen, Ailsa, Fritz, Christine, Rupp, Niels J., Poyet, Cedric, Rushing, Elisabeth, Weller, Michael, Roth, Patrick, Haralambieva, Eugenia, Hofer, Silvia, Chen, Chen, Jochum, Wolfram, Gao, Xiaofei, Teng, Xiaodong, Chen, Lirong, Zhong, Qing, Wild, Peter J., Aebersold, Ruedi, Guo, Tiannan

“…Formalin‐fixed, paraffin‐embedded (FFPE), biobanked tissue samples offer an invaluable resource for clinical and biomarker research. Here, we developed a…”
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Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma by Wiestler, Benedikt, Capper, David, Sill, Martin, Jones, David T. W., Hovestadt, Volker, Sturm, Dominik, Koelsche, Christian, Bertoni, Anna, Schweizer, Leonille, Korshunov, Andrey, Weiß, Elisa K., Schliesser, Maximilian G., Radbruch, Alexander, Herold-Mende, Christel, Roth, Patrick, Unterberg, Andreas, Hartmann, Christian, Pietsch, Torsten, Reifenberger, Guido, Lichter, Peter, Radlwimmer, Bernhard, Platten, Michael, Pfister, Stefan M., von Deimling, Andreas, Weller, Michael, Wick, Wolfgang

“…The outcome of patients with anaplastic gliomas varies considerably. Whether a molecular classification of anaplastic gliomas based on large-scale genomic or…”
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Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report by Steinegger, Lukas, Nierobisch, Nathalie, De Vere-Tyndall, Anthony, Schreiner, Bettina, Roth, Patrick, Kappos, Ludwig, Kana, Veronika, Herwerth, Marina

“…Daratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune…”
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How we treat glioblastoma by Weller, Michael, Le Rhun, Emilie, Preusser, Matthias, Tonn, Jörg-Christian, Roth, Patrick

“…Glioblastoma is an intrinsic brain tumour thought to arise from neuroglial progenitor cells. Its incidence increases steadily with age. Males are moderately…”
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