Search Results - "Roth, Mitchell O."

“X” marks the spot: Mining the gold in CasX for gene editing by Roth, Mitchell O., Li, Hong

“…In this issue of Molecular Cell, Tsuchida et al. (2022) present a successful structure-guided effort in improving genome-editing efficiencies of CRISPR-CasX…”
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Coupled catalytic states and the role of metal coordination in Cas9 by Das, Anuska, Rai, Jay, Roth, Mitchell O., Shu, Yuerong, Medina, Megan L., Barakat, Mackenzie R., Li, Hong

“…Controlling the activity of the CRISPR–Cas9 system is essential to its safe adoption for clinical and research applications. Although the conformational…”
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Phosphate Lock Residues of Acidothermus cellulolyticus Cas9 Are Critical to Its Substrate Specificity by Hand, Travis H, Das, Anuska, Roth, Mitchell O, Smith, Chardasia L, Jean-Baptiste, Uriel L, Li, Hong

“…Despite being utilized widely in genome sciences, CRISPR-Cas9 remains limited in achieving high fidelity in cleaving DNA. A better understanding of the…”
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A Catalytically Enhanced Type II-C Cas9 through Directed Protien Evolution by Hand, Travis H., Roth, Mitchell O., Smith, Chardasia L., Shiel, Emily, Li, Hong

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