Search Results - "Roth, Michael G"

Molecular Mechanisms of PLD Function in Membrane Traffic by Roth, Michael G

“…The two mammalian phosphatidylcholine (PC)-selective phospholipase D (PLD) enzymes remove the choline head group from PC to produce phosphatidic acid (PA). PA…”
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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer by Lum, Lawrence, Chen, Baozhi, Dodge, Michael E, Tang, Wei, Lu, Jianming, Ma, Zhiqiang, Fan, Chih-Wei, Wei, Shuguang, Hao, Wayne, Kilgore, Jessica, Williams, Noelle S, Roth, Michael G, Amatruda, James F, Chen, Chuo

“…The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to identify small molecules that…”
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Phosphoinositides in Constitutive Membrane Traffic by Roth, Michael G

“…Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas Proteins that make, consume, and bind to phosphoinositides…”
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Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway by Wang, May-Yun, Yan, Hai, Shi, Zhiqing, Evans, Matthew R., Yu, Xinxin, Lee, Young, Chen, Shiuhwei, Williams, Annie, Philippe, Jacques, Roth, Michael G., Unger, Roger H.

“…Insulin monotherapy can neither maintain normoglycemia in type 1 diabetes (T1D) nor prevent the long-term damage indicated by elevated glycation products in…”
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Systematic Identification of Molecular Subtype-Selective Vulnerabilities in Non-Small-Cell Lung Cancer by Kim, Hyun Seok, Mendiratta, Saurabh, Kim, Jiyeon, Pecot, Chad Victor, Larsen, Jill E., Zubovych, Iryna, Seo, Bo Yeun, Kim, Jimi, Eskiocak, Banu, Chung, Hannah, McMillan, Elizabeth, Wu, Sherry, De Brabander, Jef, Komurov, Kakajan, Toombs, Jason E., Wei, Shuguang, Peyton, Michael, Williams, Noelle, Gazdar, Adi F., Posner, Bruce A., Brekken, Rolf A., Sood, Anil K., Deberardinis, Ralph J., Roth, Michael G., Minna, John D., White, Michael A.

“…Context-specific molecular vulnerabilities that arise during tumor evolution represent an attractive intervention target class. However, the frequency and…”
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SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers by Tagal, Vural, Wei, Shuguang, Zhang, Wei, Brekken, Rolf A., Posner, Bruce A., Peyton, Michael, Girard, Luc, Hwang, TaeHyun, Wheeler, David A., Minna, John D., White, Michael A., Gazdar, Adi F., Roth, Michael G.

“…Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no…”
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A New Biology of Diabetes Revealed by Leptin by Unger, Roger H., Roth, Michael G.

“…A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a…”
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Synthetic lethal screen identification of chemosensitizer loci in cancer cells by Peyton, Michael, Bodemann, Brian O, Minna, John D, Hao, Weihua, Ferguson, Deborah, White, Michael A, Xie, Xian-Jin, Cardenas, Jessica, Roth, Michael G, Girard, Luc, Michnoff, Carolyn, Whitehurst, Angelique W

“…Abundant evidence suggests that a unifying principle governing the molecular pathology of cancer is the co-dependent aberrant regulation of core machinery…”
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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells by Lee, Young, Berglund, Eric D., Yu, Xinxin, Wang, May-Yun, Evans, Matthew R., Scherer, Philipp E., Holland, William L., Charron, Maureen J., Roth, Michael G., Unger, Roger H.

“…Significance Diet-induced type 2 diabetes (T2D) is becoming a worldwide epidemic. Patients with T2D fail to respond to insulin normally and have elevated blood…”
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Genome-wide siRNA-based functional genomics of pigmentation identifies novel genes and pathways that impact melanogenesis in human cells by Ganesan, Anand K, Ho, Hsiang, Bodemann, Brian, Petersen, Sean, Aruri, Jayavani, Koshy, Shiney, Richardson, Zachary, Le, Lu Q, Krasieva, Tatiana, Roth, Michael G, Farmer, Pat, White, Michael A

“…Melanin protects the skin and eyes from the harmful effects of UV irradiation, protects neural cells from toxic insults, and is required for sound conduction…”
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Phosphatidylinositol 4 Phosphate Regulates Targeting of Clathrin Adaptor AP-1 Complexes to the Golgi by Wang, Ying Jie, Wang, Jing, Sun, Hui Qiao, Martinez, Manuel, Sun, Yu Xiao, Macia, Eric, Kirchhausen, Tomas, Albanesi, Joseph P., Roth, Michael G., Yin, Helen L.

“…Phosphatidylinositol 4 phosphate [PI(4)P] is essential for secretion in yeast, but its role in mammalian cells is unclear. Current paradigms propose that…”
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Small molecule glucagon release inhibitors with activity in human islets by Kalwat, Michael A, Rodrigues-Dos-Santos, Karina, Binns, Derk D, Wei, Shuguang, Zhou, Anwu, Evans, Matthew R, Posner, Bruce A, Roth, Michael G, Cobb, Melanie H

“…Type 1 diabetes (T1D) accounts for an estimated 5% of all diabetes in the United States, afflicting over 1.25 million individuals. Maintaining long-term blood…”
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Loss of Aurora Kinase Signaling Allows Lung Cancer Cells to Adopt Endoreplication and Form Polyploid Giant Cancer Cells That Resist Antimitotic Drugs by Tagal, Vural, Roth, Michael G

“…Polyploid giant cancer cells (PGCC) are common in tumors and have been associated with resistance to cancer therapy, tumor relapse, malignancy,…”
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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor by Mata, Miguel A, Satterly, Neal, Versteeg, Gijs A, Frantz, Doug, Wei, Shuguang, Williams, Noelle, Schmolke, Mirco, Peña-Llopis, Samuel, Brugarolas, James, Forst, Christian V, White, Michael A, García-Sastre, Adolfo, Roth, Michael G, Fontoura, Beatriz M A

“…A screen for compounds that alleviate the inhibitory effect of influenza NS1 on host gene expression and suppress viral toxicity found naphthalimides that…”
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High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase by Baldwin, Jeffrey, Michnoff, Carolyn H., Malmquist, Nicholas A., White, John, Roth, Michael G., Rathod, Pradipsinh K., Phillips, Margaret A.

“…Plasmodium falciparum is the causative agent of the most serious and fatal malarial infections, and it has developed resistance to commonly employed…”
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Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export by Zhang, Liang, Das, Priyabrata, Schmolke, Mirco, Manicassamy, Balaji, Wang, Yaming, Deng, Xiaoyi, Cai, Ling, Tu, Benjamin P, Forst, Christian V, Roth, Michael G, Levy, David E, García-Sastre, Adolfo, de Brabander, Jef, Phillips, Margaret A, Fontoura, Beatriz M A

“…The NS1 protein of influenza virus is a major virulence factor essential for virus replication, as it redirects the host cell to promote viral protein…”
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Studies toward the Unique Pederin Family Member Psymberin: Structure–Activity Relationships, Biochemical Studies, and Genetics Identify the Mode-of-Action of Psymberin by Wu, Cheng-Yang, Feng, Yu, Cardenas, Eduardo R, Williams, Noelle, Floreancig, Paul E, De Brabander, Jef K, Roth, Michael G

“…Psymberin is the only member of the pederin natural product family that contains a dihydroisocoumarin side chain. Structural modifications of psymberin…”
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Evaluating the potential of Vacuolar ATPase inhibitors as anticancer agents and multigram synthesis of the potent salicylihalamide analog saliphenylhalamide by Lebreton, Sylvain, Jaunbergs, Janis, Roth, Michael G., Ferguson, Deborah A., De Brabander, Jef K.

“…The natural product salicylihalamide is a potent inhibitor of the Vacuolar ATPase (V-ATPase), a potential target for antitumor chemotherapy. We generated…”
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Host modulators of H1N1 cytopathogenicity by Ward, Samuel E, Kim, Hyun Seok, Komurov, Kakajan, Mendiratta, Saurabh, Tsai, Pei-Ling, Schmolke, Mirco, Satterly, Neal, Manicassamy, Balaji, Forst, Christian V, Roth, Michael G, García-Sastre, Adolfo, Blazewska, Katarzyna M, McKenna, Charles E, Fontoura, Beatriz M, White, Michael A

“…Influenza A virus infects 5-20% of the population annually, resulting in ~35,000 deaths and significant morbidity. Current treatments include vaccines and…”
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Inhibition of iron uptake is responsible for differential sensitivity to V-ATPase inhibitors in several cancer cell lines by Straud, Sarah, Zubovych, Iryna, De Brabander, Jef K, Roth, Michael G

“…Many cell lines derived from tumors as well as transformed cell lines are far more sensitive to V-ATPase inhibitors than normal counterparts. The molecular…”
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