Search Results - "Roth, Jerome A."

Correlation between the biochemical pathways altered by mutated parkinson-related genes and chronic exposure to manganese by Roth, Jerome A.

“…•Gene mutations promoting Parkinsonism can induce manganism.•Exposure to Mn can lead to early onset of Parkinsonism.•Parkinson-inducing gene mutations and Mn…”
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Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination by Roth, Jerome A

“…This review attempts to summarize and clarify our basic knowledge as to the various factors that potentially influence the risks imposed from chronic exposure…”
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Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats by Ding, Dalian, Salvi, Richard, Roth, Jerome A.

“…Prior studies have demonstrated that the inner ear can accumulate a variety of essential and potentially toxic heavy metals including manganese, lead, cobalt…”
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The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells by Roth, Jerome A., Li, Zhezheng, Sridhar, Swetha, Khoshbouei, Habibeh

“…► Mn is equally toxic to control and DAT transfected HEK cell whereas dopamine is only toxic to the DAT transfected cells. ► Mn suppresses DA toxicity in the…”
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Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese by Roth, Jerome A, Garrick, Michael D

“…Chronic exposure to the divalent heavy metals, such as iron, lead, manganese (Mn), and chromium, has been linked to the development of severe, often…”
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Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1 by Roth, Jerome A, Singleton, Steven, Feng, Jian, Garrick, Michael, Paradkar, Prasad N

“…J. Neurochem. (2010) 113, 454-464. Abnormal iron accumulation is linked to a variety of neurological disorders and may contribute to the progressive damage…”
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Down-regulation of LRRK2 in control and DAT transfected HEK cells increases manganese-induced oxidative stress and cell toxicity by Roth, Jerome A., Eichhorn, Michelle

“…•Transfection of an shRNA to LRRK2 in HEK cell results in decreased expression of the kinase.•LRRK2 down-regulation potentiates both Mn- and dopamine-induced…”
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Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation by Garrick, Michael D., Zhao, Lin, Roth, Jerome A., Jiang, Houbo, Feng, Jian, Foot, Natalie J., Dalton, Hazel, Kumar, Sharad, Garrick, Laura M.

“…Divalent metal ion transporter (DMT1) is the major transporter for iron entrance into mammalian cells and iron exit from endosomes during the transferrin…”
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Comparison of mammalian cell lines expressing distinct isoforms of divalent metal transporter 1 in a tetracycline-regulated fashion by Garrick, Michael D, Kuo, Hung-Chieh, Vargas, Farida, Singleton, Steven, Zhao, Lin, Smith, Jaime J, Paradkar, Prasad, Roth, Jerome A, Garrick, Laura M

“…DMT1 (divalent metal transporter; also known as SLC11A2, DCT1 or Nramp2) is responsible for ferrous iron uptake in the duodenum, iron exit from endosomes…”
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DMT1: which metals does it transport? by Garrick, Michael D, Singleton, Steven T, Vargas, Farida, Kuo, H-C, Zhao, Lin, Knöpfel, Martin, Davidson, Todd, Costa, Max, Paradkar, Prasad, Roth, Jerome A, Garrick, Laura M

“…DMT1-Divalent Metal (Ion) Transporter 1 or SLC11A2/DCT1/Nramp2 - transports Fe2+ into the duodenum and out of the endosome during the transferrin cycle. DMTI…”
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Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by retinoic acid by Paradkar, Prasad N, Roth, Jerome A

“…Studies were performed to determine the regulation of DMT1 (divalent metal transporter 1) during RA (retinoic acid)-induced differentiation of P19 embryonic…”
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Ototoxicity of Divalent Metals by Roth, Jerome A., Salvi, Richard

“…Excess exposure to both essential and non-essential heavy metals can lead to a variety of adverse clinical conditions which selectively affect a variety of…”
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Trimethyltin-induced cochlear degeneration in rat by Yu, Jintao, Ding, Dalian, Sun, Hong, Salvi, Richard, Roth, Jerome A.

“…Trimethyltin (TMT) is an occupational and environmental health hazard behaving as a potent neurotoxin known to affect the central nervous system as well as the…”
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Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism by Roth, Jerome A.

“…Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder…”
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Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells by Lis, Agnieszka, Paradkar, Prasad N., Singleton, Steve, Kuo, Hung-Chieh, Garrick, Michael D., Roth, Jerome A.

“…Although hypoxia has been shown to increase the expression of a variety of proteins involved in iron homeostasis, including transferrin and its receptor,…”
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Nicotinamide adenine dinucleotide prevents neuroaxonal degeneration induced by manganese in cochlear organotypic cultures by LU WANG, DING, Dalian, SALVI, Richard, ROTH, Jerome A

“…Manganese (Mn) is an essential trace mineral for normal growth and development. Persistent exposures to high atmospheric levels of Mn have deleterious effects…”
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Cobalt-Induced Ototoxicity in Rat Postnatal Cochlear Organotypic Cultures by Li, Peng, Ding, Dalian, Salvi, Richard, Roth, Jerome A.

“…Cobalt (Co) is a required divalent metal used in the production of metal alloys, batteries, and pigments and is a component of vitamin B12. Excessive uptake of…”
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Cellular localization and developmental changes of the different isoforms of divalent metal transporter 1 (DMT1) in the inner ear of rats by Ding, Dalian, Salvi, Richard, Roth, Jerome A.

“…Divalent metal transporter 1 (DMT1) is generally considered to be the major transmembrane protein responsible for the uptake of a variety of divalent cations…”
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Carbaryl‐induced ototoxicity in rat postnatal cochlear organotypic cultures by Prakash Krishnan Muthaiah, Vijaya, Ding, Dalian, Salvi, Richard, Roth, Jerome A.

“…ABSTRACT Carbaryl, a widely used carbamate‐based insecticide, is a potent anticholinesterase known to induce delayed neurotoxicity following chronic exposure…”
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Neurotoxicity of Trimethyltin in Rat Cochlear Organotypic Cultures by Yu, Jintao, Ding, Dalian, Sun, Hong, Salvi, Richard, Roth, Jerome A.

“…Trimethyltin (TMT), which has a variety of applications in industry and agricultural, is a neurotoxin that is known to affect the auditory system as well as…”
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