Search Results - "Roth, Jacob S"

Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19 by Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

“…The global pandemic of SARS-CoV-2, the causative viral pathogen of COVID-19, has driven the biomedical community to actionto uncover and develop antiviral…”
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A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase by Martinez, Natalia J., Asawa, Rosita R., Cyr, Matthew G., Zakharov, Alexey, Urban, Daniel J., Roth, Jacob S., Wallgren, Eric, Klumpp-Thomas, Carleen, Coussens, Nathan P., Rai, Ganesha, Yang, Shyh-Ming, Hall, Matthew D., Marugan, Juan J., Simeonov, Anton, Henderson, Mark J.

“…Assessment of the interactions between a drug and its protein target in a physiologically relevant cellular environment constitutes a major challenge in the…”
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Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation by Maron, Maxim I, Casill, Alyssa D, Gupta, Varun, Roth, Jacob S, Sidoli, Simone, Query, Charles C, Gamble, Matthew J, Shechter, David

“…Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I PRMT enzymes catalyze mono- and asymmetric…”
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PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia by Li, Jianping, Hlavka-Zhang, Julia, Shrimp, Jonathan H, Piper, Crissandra, Dupéré-Richér, Daphne, Roth, Jacob S, Jing, Duohui, Casellas Román, Heidi L, Troche, Catalina, Swaroop, Alok, Kulis, Marta, Oyer, Jon A, Will, Christine M, Shen, Min, Riva, Alberto, Bennett, Richard L, Ferrando, Adolfo A, Hall, Matthew D, Lock, Richard B, Licht, Jonathan D

“…Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse…”
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Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter by Robey, Robert W., Robinson, Andrea N., Ali-Rahmani, Fatima, Huff, Lyn M., Lusvarghi, Sabrina, Vahedi, Shahrooz, Hotz, Jordan M., Warner, Andrew C., Butcher, Donna, Matta, Jennifer, Edmondson, Elijah F., Lee, Tobie D., Roth, Jacob S., Lee, Olivia W., Shen, Min, Tanner, Kandice, Hall, Matthew D., Ambudkar, Suresh V., Gottesman, Michael M.

“…Capillary endothelial cells of the human blood–brain barrier (BBB) express high levels of P-glycoprotein (P-gp, encoded by ABCB1 ) and ABCG2 (encoded by ABCG2…”
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Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19 by Eastman, Richard T, Roth, Jacob S, Brimacombe, Kyle R, Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D

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Birinapant selectively enhances immunotoxin‐mediated killing of cancer cells conditional on the IAP protein levels within target cells by Antignani, Antonella, Bilotta, Maria Teresa, Roth, Jacob S., Urban, Daniel J., Shen, Min, Hall, Matthew D., FitzGerald, David

“…Immunotoxins (ITs) target cancer cells via antibody binding to surface antigens followed by internalization and toxin‐mediated inhibition of protein synthesis…”
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The Combination of Trametinib and Ganitumab is Effective in RAS-Mutated PAX-Fusion Negative Rhabdomyosarcoma Models by Hebron, Katie E, Wan, Xiaolin, Roth, Jacob S, Liewehr, David J, Sealover, Nancy E, Frye, William J E, Kim, Angela, Stauffer, Stacey, Perkins, Olivia L, Sun, Wenyue, Isanogle, Kristine A, Robinson, Christina M, James, Amy, Awasthi, Parirokh, Shankarappa, Priya, Luo, Xiaoling, Lei, Haiyan, Butcher, Donna, Smith, Roberta, Edmondson, Elijah F, Chen, Jin-Qiu, Kedei, Noemi, Peer, Cody J, Shern, Jack F, Figg, W Douglas, Chen, Lu, Hall, Matthew D, Difilippantonio, Simone, Barr, Frederic G, Kortum, Robert L, Robey, Robert W, Vaseva, Angelina V, Khan, Javed, Yohe, Marielle E

“…PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition…”
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Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma by Stauffer, Stacey, Roth, Jacob S, Hernandez, Edjay R, Kowalczyk, Joshua T, Sealover, Nancy E, Hebron, Katie E, James, Amy, Isanogle, Kristine A, Riffle, Lisa A, Ileva, Lilia, Luo, Xiaoling, Chen, Jin-Qiu, Kedei, Noemi, Kortum, Robert L, Lei, Haiyan, Shern, Jack F, Kalen, Joseph D, Edmondson, Elijah F, Hall, Matthew D, Difilippantonio, Simone, Thiele, Carol J, Yohe, Marielle E

“…Activating mutations in the RAS/MAPK pathway are observed in relapsed neuroblastoma. Preclinical studies indicate that these tumors have an increased…”
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Keeping It Clean: The Cell Culture Quality Control Experience at the National Center for Advancing Translational Sciences by Roth, Jacob S, Lee, Tobie D, Cheff, Dorian M, Gosztyla, Maya L, Asawa, Rosita R, Danchik, Carina, Michael, Sam, Simeonov, Anton, Klumpp-Thomas, Carleen, Wilson, Kelli M, Hall, Matthew D

“…Quality control monitoring of cell lines utilized in biomedical research is of utmost importance and is critical for the reproducibility of data. Two key…”
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A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL by Li, Jianping, Troche, Catalina, Zhang, Julia Hlavka, Shrimp, Jonathan, Roth, Jacob S., Jing, Duohui, Swaroop, Alok, Kulis, Marta, Oyer, Jon, Will, Christine, Dupere-Richer, Daphne, Riva, Alberto, Pipe, Crissandra, Sobn, Amin, Norton, Sharon, Bennett, Richard Lynn, Shen, Min, Hall, Matthew D., Lock, Richard B., Licht, Jonathan D.

“…▪ Despite improvements in chemotherapy that have increased the 5-year survival rates of pediatric ALL to close to 90%, 15-20% of patients may relapse with a…”
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Abstract IA023: Therapeutic efficacy of trametinib and ganitumab in RAS-mutated rhabdomyosarcoma by Yohe, Marielle E., Hebron, Katie E., Wan, Xiaolin, Roth, Jacob S., Liewehr, David J., Sealover, Nancy E., Stauffer, Stacey, Feehan-Nelson, Olivia, Sun, Wenyue, Isanogle, Kristine A., Robinson, Christina M., James, Amy, Awasthi, Parirokh, Shankarappa, Priya, Liu, Xiaoling, Lei, Haiyan, Butcher, Donna, Smith, Roberta, Edmonson, Elijah F., Chen, Jin-Qui, Kedei, Noemi, Peer, Cody S., Shern, Jack F., Figg, W. Douglas, Chen, Lu, Hall, Matthew D., Difillipantonio, Simone, Barr, Frederic G., Kortum, Robert L., Vaseva, Angelina V., Khan, Javed

“…Abstract Background: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK…”
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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space by Kearney, Sara E, Zahoránszky-Kőhalmi, Gergely, Brimacombe, Kyle R, Henderson, Mark J, Lynch, Caitlin, Zhao, Tongan, Wan, Kanny K, Itkin, Zina, Dillon, Christopher, Shen, Min, Cheff, Dorian M, Lee, Tobie D, Bougie, Danielle, Cheng, Ken, Coussens, Nathan P, Dorjsuren, Dorjbal, Eastman, Richard T, Huang, Ruili, Iannotti, Michael J, Karavadhi, Surendra, Klumpp-Thomas, Carleen, Roth, Jacob S, Sakamuru, Srilatha, Sun, Wei, Titus, Steven A, Yasgar, Adam, Zhang, Ya-Qin, Zhao, Jinghua, Andrade, Rodrigo B, Brown, M. Kevin, Burns, Noah Z, Cha, Jin K, Mevers, Emily E, Clardy, Jon, Clement, Jason A, Crooks, Peter A, Cuny, Gregory D, Ganor, Jake, Moreno, Jesus, Morrill, Lucas A, Picazo, Elias, Susick, Robert B, Garg, Neil K, Goess, Brian C, Grossman, Robert B, Hughes, Chambers C, Johnston, Jeffrey N, Joullie, Madeleine M, Kinghorn, A. Douglas, Kingston, David G.I, Krische, Michael J, Kwon, Ohyun, Maimone, Thomas J, Majumdar, Susruta, Maloney, Katherine N, Mohamed, Enas, Murphy, Brian T, Nagorny, Pavel, Olson, David E, Overman, Larry E, Brown, Lauren E, Snyder, John K, Porco, John A, Rivas, Fatima, Ross, Samir A, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T, Xu, Zhengren, Shen, Ben, Shi, Wei, Stephenson, Corey R.J, Verano, Alyssa L, Tan, Derek S, Tang, Yi, Taylor, Richard E, Thomson, Regan J, Vosburg, David A, Wu, Jimmy, Wuest, William M, Zakarian, Armen, Zhang, Yufeng, Ren, Tianjing, Zuo, Zhong, Inglese, James, Michael, Sam, Simeonov, Anton, Zheng, Wei, Shinn, Paul, Jadhav, Ajit, Boxer, Matthew B, Hall, Matthew D, Xia, Menghang, Guha, Rajarshi, Rohde, Jason M

“…Natural products and their derivatives continue to be wellsprings of nascent therapeutic potential. However, many laboratories have limited resources for…”
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