Search Results - "Roth, JA"

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity by GU, J, ANDREEFF, M, ROTH, J. A, FANG, B

“…We recently showed that the human telomerase reverse transcriptase (hTERT) promoter induces tumor-specific Bax gene expression and selectively kills various…”
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Abstract P2-11-14: IMRT use after lumpectomy in early-Stage breast cancer: Patterns of care and cost-consequences by Roth, JA, McDougall, J, Halasz, L, Fedorenko, C, Sun, Q, Patel, S

“…Abstract BACKGROUND The American Society for Radiation Oncology (ASTRO) issued a Choosing Wisely recommendation (CWr) against use of intensity modulated…”
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PATIENT EXPERIENCES WITH LOW-DOSE CT LUNG CANCER SCREENING IN THE VETERANS HEALTH ADMINISTRATION SYSTEM by Roth, JA, Sayre, G, Todd, K, Zeliadt, S

“…OBJECTIVES: The Veterans Health Administration (VHA) was an early adopter of low-dose CT (LDCT) lung cancer screening for heavy smokers (≥30 pack-year history,…”
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Health State Utilities for Sickle Cell Disease: A Catalog Prepared From a Systematic Review by Jiao, Boshen, Basu, Anirban, Ramsey, Scott, Roth, Joshua, Bender, M.A., Quach, Dalyna, Devine, Beth

“…Sickle cell disease (SCD) is a complex, chronic condition that impairs health-related quality of life of affected individuals and their caregivers. As curative…”
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Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers by Shigematsu, Hisayuki, Lin, Li, Takahashi, Takao, Nomura, Masaharu, Suzuki, Makoto, Wistuba, Ignacio I., Fong, Kwun M., Lee, Huei, Toyooka, Shinichi, Shimizu, Nobuyoshi, Fujisawa, Takehiko, Feng, Ziding, Roth, Jack A., Herz, Joachim, Minna, John D., Gazdar, Adi F.

“…Background: Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are associated with increased…”
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Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination by Roth, Jerome A

“…This review attempts to summarize and clarify our basic knowledge as to the various factors that potentially influence the risks imposed from chronic exposure…”
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Potential Cost-Effectiveness of Neratinib Following Trastuzumab Therapy for Treatment of Early-Stage Her2-Positive Breast Cancer by Schwartz, NR, Steuten, L, Babigumira, JB, Roth, JA

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PCN102 - Potential Cost-Effectiveness of Neratinib Following Trastuzumab Therapy for Treatment of Early-Stage Her2-Positive Breast Cancer by Schwartz, NR, Steuten, L, Babigumira, JB, Roth, JA

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Adenovirus p53 gene therapy by Roth, Jack A

“…To date, dysfunctional tumour suppressor genes are the most common genetic lesions identified in human cancers. Functional copies of tumour suppressor genes…”
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Kinetics of Lung Lesion Development and Pro-Inflammatory Cytokine Response in Pigs With Vaccine-Associated Enhanced Respiratory Disease Induced by Challenge With Pandemic (2009) A/H1N1 Influenza Virus by Gauger, P. C., Vincent, A. L., Loving, C. L., Henningson, J. N., Lager, K. M., Janke, B. H., Kehrli, M. E., Roth, J. A.

“…The objective of this report was to characterize the enhanced clinical disease and lung lesions observed in pigs vaccinated with inactivated H1N2 swine…”
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PRM126 - A COMPARISON OF MIXTURE CURE AND STANDARD PARAMETRIC MODELING TO ESTIMATE LONG-TERM SURVIVAL FOR SMALL-CELL LUNG CANCER IN PATIENTS TREATED WITH NIVOLUMAB AFTER PROGRESSION by Ramsey, SD, Othus, M, Roth, JA, Yuan, Y, Wagner, S, Penrod, JR

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Focus on lung cancer by Minna, John D, Roth, Jack A, Gazdar, Adi F

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Posttherapy pathologic stage predicts survival in patients with esophageal carcinoma receiving preoperative chemoradiation by Chirieac, Lucian R., Swisher, Stephen G., Ajani, Jaffer A., Komaki, Ritsuko R., Correa, Arlene M., Morris, Jeffrey S., Roth, Jack A., Rashid, Asif, Hamilton, Stanley R., Wu, Tsung‐Teh

“…BACKGROUND In patients with locoregional carcinoma of the esophagus or esophagogastric junction who underwent preoperative chemoradiation, it is unclear…”
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Iron interactions and other biological reactions mediating the physiological and toxic actions of manganese by Roth, Jerome A, Garrick, Michael D

“…Chronic exposure to the divalent heavy metals, such as iron, lead, manganese (Mn), and chromium, has been linked to the development of severe, often…”
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BRAF and RAS mutations in human lung cancer and melanoma by BROSE, Marcia S, VOLPE, Patricia, ROTH, Jack A, ALBELDA, Steven M, DAVIES, Helen, COX, Charles, BRIGNELL, Graham, STEPHENS, Philip, FUTREAL, P. Andrew, WOOSTER, Richard, STRATTON, Michael R, WEBER, Barbara L, FELDMAN, Michael, KUMAR, Madhu, RISHI, Irum, GERRERO, Renee, EINHORN, Eugene, HERLYN, Meenhard, MINNA, John, NICHOLSON, Andrew

“…BRAF encodes a RAS-regulated kinase that mediates cell growth and malignant transformation kinase pathway activation. Recently, we have identified activating…”
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Clinical and Economic Value of a Biosimilar Portfolio to Stakeholders: An Integrative Literature Review by Fox, Grace E, Bernauer, Mark, Stephens, Jennifer M, Jackson, Bianca, Roth, Joshua A, Shelbaya, Ahmed

“…While the value of individual biosimilars is evident, little is known about the value of a biosimilar portfolio beyond the cost savings between biosimilars and…”
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ADHERENCE TO ‘CHOOSING WISELY’ RECOMMENDATIONS FOR RADIATION THERAPY IN A COMMERCIALLY INUSRED LOW-RISK ENDOMETRIAL CANCER POPULATION by Roth, JA, McDougall, J, Halasz, L, Fedorenko, CR, Sun, Q, Goulart, B, Patel, S

“…OBJECTIVES: The American Society for Radiation Oncology (ASTRO) ‘Choosing Wisely’ (CW) recommendations note radiation interventions lacking evidence of benefit…”
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Genetic Risk Factors for Major Bleeding in Patients Treated With Warfarin in a Community Setting by Roth, J A, Boudreau, D, Fujii, M M, Farin, F M, Rettie, A E, Thummel, K E, Veenstra, D L

“…The influence of warfarin pharmacogenomics on major bleeding risk has been little studied in long‐term users and non–specialist care settings. We conducted a…”
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EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage by Kuroda, Shinji, Tam, Justina, Roth, Jack A, Sokolov, Konstantin, Ramesh, Rajagopal

“…We have previously demonstrated the epidermal growth factor receptor (EGFR)-targeted hybrid plasmonic magnetic nanoparticles (225-NP) produce a therapeutic…”
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EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients by XIMING TANG, SHIGEMATSU, Hisayuki, BEKELE, B. Nebiyou, ROTH, Jack A, MINNA, John D, WAUN KI HONG, GAZDAR, Adi F, WISTUBA, Ignacio I

“…To determine whether EGFR tyrosine kinase domain mutations are early events in the pathogenesis of lung adenocarcinomas, we tested for the presence of EGFR…”
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