Search Results - "Roth, David M."

Regulation of intracellular signaling and function by caveolin by Fridolfsson, Heidi N., Roth, David M., Insel, Paul A., Patel, Hemal H.

“…Caveolae, flask‐like invaginations of the plasma membrane, were discovered nearly 60 years ago. Originally regarded as fixation artifacts of electron…”
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Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System by HEAD, Brian P, PATEL, Hemal H, NIESMAN, Ingrid R, DRUMMOND, John C, ROTH, David M, PATEL, Piyush M

“…Exposure to anesthetics during synaptogenesis results in apoptosis and subsequent cognitive dysfunction in adulthood. Probrain-derived neurotrophic factor…”
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Propofol Neurotoxicity Is Mediated by p75 Neurotrophin Receptor Activation by PEARN, Matthew L, YUE HU, NIESMAN, Ingrid R, PATEL, Hemal H, DRUMMOND, John C, ROTH, David M, AKASSOGLOU, Katerina, PATEL, Piyush M, HEAD, Brian P

“…Propofol exposure to neurons during synaptogenesis results in apoptosis, leading to cognitive dysfunction in adulthood. Previous work from our laboratory…”
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Loss of caveolin-1 accelerates neurodegeneration and aging by Head, Brian P, Peart, Jason N, Panneerselvam, Mathivadhani, Yokoyama, Takaakira, Pearn, Matthew L, Niesman, Ingrid R, Bonds, Jacqueline A, Schilling, Jan M, Miyanohara, Atsushi, Headrick, John, Ali, Sameh S, Roth, David M, Patel, Piyush M, Patel, Hemal H

“…The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such…”
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Impact of blood factors on endothelial cell metabolism and function in two diverse heart failure models by Song, Young, Leem, Joseph, Dhanani, Mehul, McKirnan, M Dan, Ichikawa, Yasuhiro, Braza, Julie, Harrington, Elizabeth O, Hammond, H Kirk, Roth, David M, Patel, Hemal H

“…Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during…”
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Neuron-Targeted Caveolin-1 Improves Molecular Signaling, Plasticity, and Behavior Dependent on the Hippocampus in Adult and Aged Mice by Mandyam, Chitra D, Schilling, Jan M, Cui, Weihua, Egawa, Junji, Niesman, Ingrid R, Kellerhals, Sarah E, Staples, Miranda C, Busija, Anna R, Risbrough, Victoria B, Posadas, Edmund, Grogman, Grace C, Chang, Jamie W, Roth, David M, Patel, Piyush M, Patel, Hemal H, Head, Brian P

“…Abstract Background Studies in vitro demonstrate that neuronal membrane/lipid rafts (MLRs) establish cell polarity by clustering progrowth receptors and…”
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Microtubules and Actin Microfilaments Regulate Lipid Raft/Caveolae Localization of Adenylyl Cyclase Signaling Components by Head, Brian P., Patel, Hemal H., Roth, David M., Murray, Fiona, Swaney, James S., Niesman, Ingrid R., Farquhar, Marilyn G., Insel, Paul A.

“…Microtubules and actin filaments regulate plasma membrane topography, but their role in compartmentation of caveolae-resident signaling components, in…”
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Cardiac-Specific Overexpression of Caveolin-3 Attenuates Cardiac Hypertrophy and Increases Natriuretic Peptide Expression and Signaling by Horikawa, Yousuke T., PhD, Panneerselvam, Mathivadhani, PhD, Kawaraguchi, Yoshitaka, MD, Tsutsumi, Yasuo M., MD, PhD, Ali, Sameh S., PhD, Balijepalli, Ravi C., PhD, Murray, Fiona, PhD, Head, Brian P., PhD, Niesman, Ingrid R., MS, Rieg, Timo, MD, Vallon, Volker, MD, Insel, Paul A., MD, Patel, Hemal H., PhD, Roth, David M., PhD, MD

“…Objectives We hypothesized that cardiac myocyte-specific overexpression of caveolin-3 (Cav-3), a muscle-specific caveolin, would alter natriuretic peptide…”
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Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia by Kassan, Adam, Egawa, Junji, Zhang, Zheng, Almenar-Queralt, Angels, Nguyen, Quynh My, Lajevardi, Yasaman, Kim, Kaitlyn, Posadas, Edmund, Jeste, Dilip V, Roth, David M, Patel, Piyush M, Patel, Hemal H, Head, Brian P

“…Schizophrenia is a debilitating psychiatric disorder manifested in early adulthood. Disrupted-in-schizophrenia-1 (DISC1) is a susceptible gene for…”
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The Cyclic AMP Effector Epac Integrates Pro- and Anti-Fibrotic Signals by Yokoyama, Utako, Patel, Hemal H., Lai, N. Chin, Aroonsakool, Nakon, Roth, David M., Insel, Paul A.

“…Scar formation occurs during the late stages of the inflammatory response but, when excessive, produces fibrosis that can lead to functional and structural…”
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Volatile Anesthetics Protect Cancer Cells against Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis via Caveolins by KAWARAGUCHI, Yoshitaka, HORIKAWA, Yousuke T, MURPHY, Anne N, MURRAY, Fiona, MIYANOHARA, Atsushi, ALI, Sameh S, HEAD, Brian P, PATEL, Piyush M, ROTH, David M, PATEL, Hemal H

“…Volatile anesthetics have a dual effect on cell survival dependent on caveolin expression. The effect of volatile anesthetics on cancer cell survival and death…”
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Helium-Induced Changes in Circulating Caveolin in Mice Suggest a Novel Mechanism of Cardiac Protection by Weber, Nina C, Schilling, Jan M, Warmbrunn, Moritz V, Dhanani, Mehul, Kerindongo, Raphaela, Siamwala, Jamila, Song, Young, Zemljic-Harpf, Alice E, Fannon, McKenzie J, Hollmann, Markus W, Preckel, Benedikt, Roth, David M, Patel, Hemal H

“…The noble gas helium (He) induces cardioprotection in vivo through unknown molecular mechanisms. He can interact with and modify cellular membranes. Caveolae…”
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Mitochondria‐localized caveolin in adaptation to cellular stress and injury by Fridolfsson, Heidi N., Kawaraguchi, Yoshitaka, Ali, Sameh S., Panneerselvam, Mathivadhani, Niesman, Ingrid R., Finley, J. Cameron, Kellerhals, Sarah E., Migita, Michael Y., Okada, Hideshi, Moreno, Ana L., Jennings, Michelle, Kidd, Michael W., Bonds, Jacqueline A., Balijepalli, Ravi C., Ross, Robert S., Patel, Piyush M., Miyanohara, Atsushi, Chen, Qun, Lesnefsky, Edward J., Head, Brian P., Roth, David M., Insel, Paul A., Patel, Hemal H.

“…We show here that the apposition of plasma membrane caveolae and mitochondria (first noted in electron micrographs >50 yr ago) and caveolae‐mitochondria…”
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Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice by Niesman, Ingrid R, Schilling, Jan M, Shapiro, Lee A, Kellerhals, Sarah E, Bonds, Jacqueline A, Kleschevnikov, Alexander M, Cui, Weihua, Voong, April, Krajewski, Stan, Ali, Sameh S, Roth, David M, Patel, Hemal H, Patel, Piyush M, Head, Brian P

“…Traumatic brain injury (TBI) enhances pro-inflammatory responses, neuronal loss and long-term behavioral deficits. Caveolins (Cavs) are regulators of neuronal…”
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Cardiac-Specific Overexpression of Caveolin-3 Induces Endogenous Cardiac Protection by Mimicking Ischemic Preconditioning by TSUTSUMI, Yasuo M, HORIKAWA, Yousuke T, PATEL, Piyush M, INSEL, Paul A, PATEL, Hemal H, ROTH, David M, JENNINGS, Michelle M, KIDD, Michael W, NIESMAN, Ingrid R, YOKOYAMA, Utako, HEAD, Brian P, HAGIWARA, Yasuko, ISHIKAWA, Yoshihiro, MIYANOHARA, Atsushi

“…Caveolae, lipid-rich microdomains of the sarcolemma, localize and enrich cardiac-protective signaling molecules. Caveolin-3 (Cav-3), the dominant isoform in…”
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Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs by Wang, Shanshan, Zhang, Zheng, Almenar-Queralt, Angels, Leem, Joseph, DerMardirossian, Celine, Roth, David M, Patel, Piyush M, Patel, Hemal H, Head, Brian P

“…Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic…”
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Efficacy of Methylprednisolone in Preventing Lung Injury Following Pulmonary Thromboendarterectomy by Kerr, Kim M., MD, FCCP, Auger, William R., MD, Marsh, James J., PhD, Devendra, Gehan, MD, Spragg, Roger G., MD, Kim, Nick H., MD, Channick, Richard N., MD, FCCP, Jamieson, Stuart W., MB, Madani, Michael M., MD, Manecke, Gerard R., MD, Roth, David M., MD, PhD, Shragg, Gordon P., MA, Fedullo, Peter F., MD, FCCP

“…Background We sought to determine the efficacy and safety of perioperative treatment with methylprednisolone on the development of lung injury after pulmonary…”
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Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle Cells by Kopp, Elena L, Deussen, Daniel N, Cuomo, Raphael, Lorenz, Reinhard, Roth, David M, Mahata, Sushil K, Patel, Hemal H

“…Type 2 diabetes (T2D) has a complex pathophysiology which makes modeling the disease difficult. We aimed to develop a novel model for simulating T2D in vitro,…”
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Modulation of caveolins, integrins and plasma membrane repair proteins in anthracycline-induced heart failure in rabbits by Ichikawa, Yasuhiro, Zemljic-Harpf, Alice E, Zhang, Zheng, McKirnan, M Dan, Manso, Ana Maria, Ross, Robert S, Hammond, H Kirk, Patel, Hemal H, Roth, David M

“…Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an…”
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Inhibition of Cardiac Myofibroblast Formation and Collagen Synthesis by Activation and Overexpression of Adenylyl Cyclase by Swaney, James S., Roth, David M., Olson, Erik R., Naugle, Jennifer E., Meszaros, J. Gary, Insel, Paul A., Seegmiller, J. Edwin

“…Transformation of fibroblasts to myofibroblasts, characterized by expression of α-smooth muscle actin (α-SMA) and production of extracellular matrix (ECM)…”
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