Search Results - "Roth, Christopher B."

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions by Liu, Wei, Chun, Eugene, Thompson, Aaron A., Chubukov, Pavel, Xu, Fei, Katritch, Vsevolod, Han, Gye Won, Roth, Christopher B., Heitman, Laura H., IJzerman, Adriaan P., Cherezov, Vadim, Stevens, Raymond C.

“…Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been…”
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Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1 by Chrencik, Jill E., Roth, Christopher B., Terakado, Masahiko, Kurata, Haruto, Omi, Rie, Kihara, Yasuyuki, Warshaviak, Dora, Nakade, Shinji, Asmar-Rovira, Guillermo, Mileni, Mauro, Mizuno, Hirotaka, Griffith, Mark T., Rodgers, Caroline, Han, Gye Won, Velasquez, Jeffrey, Chun, Jerold, Stevens, Raymond C., Hanson, Michael A.

“…Lipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of…”
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Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors by Chun, Eugene, Thompson, Aaron A., Liu, Wei, Roth, Christopher B., Griffith, Mark T., Katritch, Vsevolod, Kunken, Joshua, Xu, Fei, Cherezov, Vadim, Hanson, Michael A., Stevens, Raymond C.

“…Structural studies of human G protein-coupled receptors (GPCRs) have recently been accelerated through the use of a fusion partner that was inserted into the…”
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Flexibility in the ABC Transporter MsbA: Alternating Access with a Twist by Ward, Andrew, Reyes, Christopher L., Yu, Jodie, Roth, Christopher B., Chang, Geoffrey

“…ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a wide variety of substrates across cellular membranes and are…”
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Crystal Structure of a Lipid G Protein—Coupled Receptor by Hanson, Michael A., Roth, Christopher B., Jo, Euijung, Griffith, Mark T., Scott, Fiona L., Reinhart, Greg, Desale, Hans, Clemons, Bryan, Cahalan, Stuart M., Schuerer, Stephan C., Sanna, M. Germana, Han, Gye Won, Kuhn, Peter, Rosen, Hugh, Stevens, Raymond C.

“…The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking, endothelial development and integrity, heart rate, and vascular tone and…”
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A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor by Hanson, Michael A., Cherezov, Vadim, Griffith, Mark T., Roth, Christopher B., Jaakola, Veli-Pekka, Chien, Ellen Y.T., Velasquez, Jeffrey, Kuhn, Peter, Stevens, Raymond C.

“…The role of cholesterol in eukaryotic membrane protein function has been attributed primarily to an influence on membrane fluidity and curvature. We present…”
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Structure of MsbA from E. coli: A Homolog of the Multidrug Resistance ATP Binding Cassette (ABC) Transporters by Chang, Geoffrey, Roth, Christopher B.

“…Multidrug resistance (MDR) is a serious medical problem and presents a major challenge to the treatment of disease and the development of novel therapeutics…”
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Analysis of full and partial agonists binding to β2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes by Katritch, Vsevolod, Reynolds, Kimberly A., Cherezov, Vadim, Hanson, Michael A., Roth, Christopher B., Yeager, Mark, Abagyan, Ruben

“…The 2.4 Å crystal structure of the β2‐adrenergic receptor (β2AR) in complex with the high‐affinity inverse agonist (−)‐carazolol provides a detailed structural…”
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Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure by Roth, Christopher B., Hanson, Michael A., Stevens, Raymond C.

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Stabilization of the Human β 2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu122 3.41, A Critical Residue in GPCR Structure by Roth, Christopher B., Hanson, Michael A., Stevens, Raymond C.

“…G protein-coupled receptor (GPCR) instability represents one of the most profound obstacles in the structural study of GPCRs that bind diffusible ligands. The…”
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Stabilization of the β2-adrenergic Receptor 4-3-5 Helix Interface by Mutagenesis of Glu-1223.41, A Critical Residue in GPCR Structure by Roth, Christopher B., Hanson, Michael A., Stevens, Raymond C.

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ionsa by Liu, Wei, Chun, Eugene, Thompson, Aaron A., Chubukov, Pavel, Xu, Fei, Katritch, Vsevolod, Han, Gye Won, Roth, Christopher B., Heitman, Laura H., IJzerman, Adriaan P., Cherezov, Vadim, Stevens, Raymond C.

“…Pharmacological responses of G protein-coupled receptors (GPCRs) can be fine-tuned by allosteric modulators. Structural studies of such effects have been…”
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Retraction by Chang, Geoffrey, Roth, Christopher B., Reyes, Christopher L., Pornillos, Owen, Chen, Yen-Ju, Chen, Andy P.

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Retraction by Chang, Geoffrey, Roth, Christopher B., Reyes, Christopher L., Pornillos, Owen, Chen, Yen-Ju, Chen, Andy P.

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Analysis of full and partial agonists binding to beta(2)-adrenergic Analysis of full and partial agonists binding to beta(2)-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes by Katritch, Vsevolod, Reynolds, Kimberly A, Cherezov, Vadim, Hanson, Michael A, Roth, Christopher B, Yeager, Mark, Abagyan, Ruben

“…The 2.4 A(ngstrom) crystal structure of the beta(2)-adrenergic receptor (beta(2)AR) in complex with the high-affinity inverse agonist (-)-carazolol provides a…”
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Analysis of full and partial agonists binding to β 2 ‐adrenergic receptor suggests a role of transmembrane helix V in agonist‐specific conformational changes by Katritch, Vsevolod, Reynolds, Kimberly A., Cherezov, Vadim, Hanson, Michael A., Roth, Christopher B., Yeager, Mark, Abagyan, Ruben

“…The 2.4 Å crystal structure of the β 2 ‐adrenergic receptor ( β 2 AR) in complex with the high‐affinity inverse agonist (−)‐carazolol provides a detailed…”
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A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor in an alternate crystal form by Hanson, Michael A., Cherezov, Vadim, Roth, Christopher B., Griffith, Mark T., Jaakola, Veli-Pekka, Chien, Ellen Y. T., Velasquez, Jeffrey, Kuhn, Peter, Stevens, Raymond C.

“…The role of cholesterol in eukaryotic membrane protein function has been primarily attributed to an influence on membrane fluidity and curvature. Herein, we…”
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A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor by Hanson, Michael A, Cherezov, Vadim, Griffith, Mark T, Roth, Christopher B, Jaakola, Veli-Pekka, Chien, Ellen Y T, Velasquez, Jeffrey, Kuhn, Peter, Stevens, Raymond C

“…The role of cholesterol in eukaryotic membrane protein function has been attributed primarily to an influence on membrane fluidity and curvature. We present…”
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Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure by Roth, Christopher B, Hanson, Michael A, Stevens, Raymond C

“…G protein-coupled receptor (GPCR) instability represents one of the most profound obstacles in the structural study of GPCRs that bind diffusible ligands. The…”
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β-adrenergic receptor stability engineering for the advancement of GPCR structural biology by Roth, Christopher B

“…G-protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, accounting for >1% of the human genome and are the target of more than…”
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