Search Results - "Rotgeri, A."

In vivo models and decision trees for formulation development in early drug development: A review of current practices and recommendations for biopharmaceutical development by Zane, P., Gieschen, H., Kersten, E., Mathias, N., Ollier, C., Johansson, P., Van den Bergh, A., Van Hemelryck, S., Reichel, A., Rotgeri, A., Schäfer, K., Müllertz, A., Langguth, P.

“…[Display omitted] The ability to predict new chemical entity performance using in vivo animal models has been under investigation for more than two decades…”
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A prostaglandin E2 receptor antagonist prevents pregnancies during a preclinical contraceptive trial with female macaques by Peluffo, M C, Stanley, J, Braeuer, N, Rotgeri, A, Fritzemeier, K-H, Fuhrmann, U, Buchmann, B, Adevai, T, Murphy, M J, Zelinski, M B, Lindenthal, B, Hennebold, J D, Stouffer, R L

“…Can administration of a prostaglandin (PG) E2 receptor 2 (PTGER2) antagonist prevent pregnancy in adult female monkeys by blocking periovulatory events in the…”
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Subcellular Distribution of Epothilones in Human Tumor Cells by Lichtner, R. B., Rotgeri, A., Bunte, T., Buchmann, B., Hoffmann, J., Schwede, W., Skuballa, W., Klar, U.

“…Epothilones are a new class of natural and potent antineoplastic agents that stabilize microtubules. Although 12,13-epoxide derivatives are potent…”
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Characterization of anastrozole effects, delivered by an intravaginal ring in cynomolgus monkeys by Rotgeri, Andrea, Korolainen, Henriikka, Sundholm, Oskari, Schmitz, Heinz, Fuhrmann, Ulrike, Prelle, Katja, Sacher, Frank

“…STUDY QUESTION Is it feasible to deliver anastrozole (ATZ), an aromatase inhibitor (AI), by a vaginal polymer-based drug delivery system in the cynomolgus…”
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521 New synthetic Epothilone derivative ZKEPO inhibits the proliferation of a human glioma implanted orthotopically in nude mice by Hoffmann, J., Lichtner, R.B., Rotgeri, A., Fichtner, I., Klar, U.

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538 New synthetic Epothilone derivative ZK-EPO inhibits tumors generally resistant to chemotherapy by Klar, U., Hoffmann, J., Rotgeri, A., Buchmann, B., Schwede, W., Skuballa, W., Lichtner, R.B.

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Molecular cloning and sequence analyses of rat liver dihydroorotate dehydrogenase by Rotgeri, A, Löffler, M

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Half of Saccharomyces cerevisiae Carbamoyl Phosphate Synthetase Produces and Channels Carbamoyl Phosphate to the Fused Aspartate Transcarbamoylase Domain by Serre, Valérie, Guy, Hedeel, Penverne, Bernadette, Lux, Michèle, Rotgeri, Andrea, Evans, David, Hervé, Guy

“…The first two steps of the de novo pyrimidine biosynthetic pathway in Saccharomyces cerevisiae are catalyzed by a 240-kDa bifunctional protein encoded by the…”
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Rat Dihydroorotate Dehydrogenase: Isolation of the Recombinant Enzyme from Mitochondria of Insect Cells by Knecht, Wolfgang, Altekruse, Dagmar, Rotgeri, Andrea, Gonski, Sigrid, Löffler, Monika

“…Mammalian dihydroorotate dehydrogenase (EC 1.3.99.11), the fourth enzyme of pyrimidinede novosynthesis is located in the mitochondrial inner membrane with…”
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Activation by Fusion of the Glutaminase and Synthetase Subunits of Escherichia coli Carbamyl-phosphate Synthetase by Guy, Hedeel I., Rotgeri, Andrea, Evans, David R.

“…Escherichia coli carbamyl-phosphate synthetase consists of two subunits that act in concert to synthesize carbamyl phosphate. The 40-kDa subunit is an…”
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