Search Results - "Rotenberg, Susan A"
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Direct Electrochemical Measurements of Reactive Oxygen and Nitrogen Species in Nontransformed and Metastatic Human Breast Cells
Published in Journal of the American Chemical Society (20-09-2017)“…The production of reactive oxygen and nitrogen species (ROS and RNS) in human cells is implicated in various diseases, including cancer. Micrometer-sized…”
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Phosphorylation of Cdc42 Effector Protein-4 (CEP4) by Protein Kinase C Promotes Motility of Human Breast Cells
Published in The Journal of biological chemistry (12-09-2014)“…Cdc42 effector protein-4 (CEP4) was recently identified by our laboratory to be a substrate of multiple PKC isoforms in non-transformed MCF-10A human breast…”
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Nanoelectrochemistry of mammalian cells
Published in Proceedings of the National Academy of Sciences - PNAS (15-01-2008)“…There is a significant current interest in development of new techniques for direct characterization of the intracellular redox state and high-resolution…”
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Electrochemical attosyringe
Published in Proceedings of the National Academy of Sciences - PNAS (17-07-2007)“…The ability to manipulate ultrasmall volumes of liquids is essential in such diverse fields as cell biology, microfluidics, capillary chromatography, and…”
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Export of a single drug molecule in two transport cycles by a multidrug efflux pump
Published in Nature communications (08-08-2014)“…Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug…”
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Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells
Published in Molecular and cellular biochemistry (01-04-2015)“…Resveratrol ( E -3,5,4′-trihydroxystilbene) is a polyphenol found in red wine that has been shown to have multiple anti-cancer properties. Although cis -( Z )-…”
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Electrochemical Measurements of Reactive Oxygen and Nitrogen Species inside Single Phagolysosomes of Living Macrophages
Published in Journal of the American Chemical Society (20-03-2019)“…The release of reactive oxygen and nitrogen species (ROS/RNS) by macrophages undergoing phagocytosis is crucial for the efficiency of the immune system. In…”
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Electrochemical Resistive-Pulse Sensing of Extracellular Vesicles
Published in Analytical chemistry (Washington) (20-09-2022)“…Extracellular vesicles (EVs) released from biological cells have attracted considerable interest due to their potential for cancer diagnostics and important…”
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Scanning Electrochemical Microscopy of Living Cells: Different Redox Activities of Nonmetastatic and Metastatic Human Breast Cells
Published in Proceedings of the National Academy of Sciences - PNAS (29-08-2000)“…Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application…”
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Scanning Electrochemical Microscopy of Living Cells. 5. Imaging of Fields of Normal and Metastatic Human Breast Cells
Published in Analytical chemistry (Washington) (15-08-2003)“…Scanning electrochemical microscopy (SECM) was used to image fields of different types of human breast cells in monolayer culture. The goal of these…”
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Phosphomimetic Mutation at Ser165 of α‑Tubulin Promotes the Persistence of GTP Caps in Microtubules
Published in Biochemistry (Easton) (19-07-2022)“…Protein kinase C (PKC)-mediated phosphorylation of α-tubulin at Ser165 or expression of phosphomimetic (S165D)-α-tubulin stimulates microtubule (MT)…”
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Heterometallic titanium-gold complexes inhibit renal cancer cells in vitro and in vivo
Published in Chemical science (Cambridge) (01-09-2015)“…Following recent work on heterometallic titanocene-gold complexes as potential chemotherapeutics for renal cancer, we report here on the synthesis,…”
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Scanning Electrochemical Microscopy of Living Cells. 4. Mechanistic Study of Charge Transfer Reactions in Human Breast Cells
Published in Analytical chemistry (Washington) (15-12-2002)“…Scanning electrochemical microscopy (SECM) has recently been employed for probing the redox properties of individual mammalian cells. It was shown that…”
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Resistive-Pulse Sensing Inside Single Living Cells
Published in Journal of the American Chemical Society (25-03-2020)“…Resistive-pulse sensing is a technique widely used to detect single nanoscopic entities such as nanoparticles and large molecules that can block the ion…”
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Phosphorylation state of Ser165 in α-tubulin is a toggle switch that controls proliferating human breast tumors
Published in Cellular signalling (01-12-2018)“…Engineered overexpression of protein kinase Cα (PKCα) is known to phosphorylate Ser165 in α-tubulin resulting in stimulated microtubule dynamics and cell…”
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PhosphoMARCKS drives motility of mouse melanoma cells
Published in Cellular signalling (01-07-2010)“…Phosphorylation of myristoylated alanine-rich C- kinase substrate (MARCKS) by protein kinase Cα (PKCα) is known to trigger its release from the plasma…”
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Phosphorylation of α-tubulin by protein kinase C stimulates microtubule dynamics in human breast cells
Published in Cytoskeleton (Hoboken, N.J.) (01-04-2014)“…Protein kinase C (PKC) engenders motility through phosphorylation of α‐tubulin at Ser‐165 in nontransformed MCF‐10A cells. Live cell imaging explored the…”
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Dequalinium blocks macrophage-induced metastasis following local radiation
Published in Oncotarget (29-09-2015)“…A major therapeutic obstacle in clinical oncology is intrinsic or acquired resistance to therapy, leading to subsequent relapse. We have previously shown that…”
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Phosphorylation of α6-Tubulin by Protein Kinase Cα Activates Motility of Human Breast Cells
Published in The Journal of biological chemistry (26-06-2009)“…Engineered overexpression of protein kinase Cα (PKCα) was previously shown to endow nonmotile MCF-10A human breast cells with aggressive motility. A traceable…”
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