Search Results - "Rota, Paola"

2-Arachidonoylglycerol Synthesis: Facile and Handy Enzymatic Method That Allows to Avoid Isomerization by Ottria, Roberta, Casati, Silvana, Rota, Paola, Ciuffreda, Pierangela

“…A simple and practical synthesis of 2-arachidonoyl glycerol (2-AG), an endogenous agonist for cannabinoid receptors, based on a two-step enzymatic process and…”
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Cenobamate: A Review of its Pharmacological Properties, Clinical Efficacy and Tolerability Profile in the Treatment of Epilepsy by Barbieri, Maria Antonietta, Perucca, Emilio, Spina, Edoardo, Rota, Paola, Franco, Valentina

“…Cenobamate is a novel antiseizure medication (ASM) commercially available in Europe and in the U.S. for the treatment of focal seizures in adults. The…”
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Clarifying the Use of Benzylidene Protecting Group for D-(+)-Ribono-1,4-Lactone, an Essential Building Block in the Synthesis of C-Nucleosides by Casati, Silvana, Rota, Paola, Allevi, Pietro, Mingione, Alessandra, Ottria, Roberta, Ciuffreda, Pierangela

“…In the last two years, nucleosides analogues, a class of well-established bioactive compounds, have been the subject of renewed interest from the scientific…”
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Intramolecular Lactones of Sialic Acids by Rota, Paola, La Rocca, Paolo, Allevi, Pietro, Pappone, Carlo, Anastasia, Luigi

“…The so-called " " has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play…”
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Small-Molecules as Chemiluminescent Probes to Detect Lipase Activity by La Rocca, Paolo, Mingione, Alessandra, Casati, Silvana, Ottria, Roberta, Allevi, Pietro, Ciuffreda, Pierangela, Rota, Paola

“…The set-up of highly sensitive detection tools to evaluate lipase activity remains a central goal in different fields. In this context, we proposed new…”
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The antithetic role of ceramide and sphingosine‐1‐phosphate in cardiac dysfunction by Cirillo, Federica, Piccoli, Marco, Ghiroldi, Andrea, Monasky, Michelle M., Rota, Paola, La Rocca, Paolo, Tarantino, Adriana, D'Imperio, Sara, Signorelli, Paola, Pappone, Carlo, Anastasia, Luigi

“…Cardiovascular diseases (CVDs) are the leading cause of death globally and the number of cardiovascular patients, which is estimated to be over 30 million in…”
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Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation by Ghiroldi, Andrea, Piccoli, Marco, Creo, Pasquale, Cirillo, Federica, Rota, Paola, D'Imperio, Sara, Ciconte, Giuseppe, Monasky, Michelle M, Micaglio, Emanuele, Garatti, Andrea, Aureli, Massimo, Carsana, Emma Veronica, Menicanti, Lorenzo, Pappone, Carlo, Anastasia, Luigi

“…Cardiac fibrosis is a key physiological response to cardiac tissue injury to protect the heart from wall rupture. However, its progression increases heart…”
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A New Ultrasensitive Bioluminescence-Based Method for Assaying Monoacylglycerol Lipase by Miceli, Matteo, Casati, Silvana, Allevi, Pietro, Berra, Silvia, Ottria, Roberta, Rota, Paola, Branchini, Bruce R., Ciuffreda, Pierangela

“…A novel bioluminescent Monoacylglycerol lipase (MAGL) substrate 6-O-arachidonoylluciferin, a D-luciferin derivative, was synthesized, physico-chemically…”
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Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α by Cirillo, Federica, Mangiavini, Laura, La Rocca, Paolo, Piccoli, Marco, Ghiroldi, Andrea, Rota, Paola, Tarantino, Adriana, Canciani, Barbara, Coviello, Simona, Messina, Carmelo, Ciconte, Giuseppe, Pappone, Carlo, Peretti, Giuseppe Maria, Anastasia, Luigi

“…Sarcopenia, an age-related decline in muscle mass and strength, is associated with metabolic disease and increased risk of cardiovascular morbidity and…”
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Neu3 Sialidase Activates the RISK Cardioprotective Signaling Pathway during Ischemia and Reperfusion Injury (IRI) by Piccoli, Marco, Coviello, Simona, Canali, Maria Elena, Rota, Paola, La Rocca, Paolo, Cirillo, Federica, Lavota, Ivana, Tarantino, Adriana, Ciconte, Giuseppe, Pappone, Carlo, Ghiroldi, Andrea, Anastasia, Luigi

“…Coronary reperfusion strategies are life-saving approaches to restore blood flow to cardiac tissue after acute myocardial infarction (AMI). However, the sudden…”
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On-Line Solid Phase Extraction High Performance Liquid Chromatography Method Coupled With Tandem Mass Spectrometry for the Therapeutic Monitoring of Cannabidiol and 7-Hydroxy-cannabidiol in Human Serum and Saliva by Franco, Valentina, Palmisani, Michela, Marchiselli, Roberto, Crema, Francesca, Fattore, Cinzia, De Giorgis, Valentina, Varesio, Costanza, Rota, Paola, Dibari, Vincenza Flora, Perucca, Emilio

“…Cannabidiol is a novel antiseizure medication approved in Europe and the US for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet…”
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Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate by Piccoli, Marco, Cirillo, Federica, Ghiroldi, Andrea, Rota, Paola, Coviello, Simona, Tarantino, Adriana, La Rocca, Paolo, Lavota, Ivana, Creo, Pasquale, Signorelli, Paola, Pappone, Carlo, Anastasia, Luigi

“…Sphingolipids are bioactive molecules that play either pro- and anti-atherogenic roles in the formation and maturation of atherosclerotic plaques. Among SLs,…”
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Curcumin and Novel Synthetic Analogs in Cell-Based Studies of Alzheimer's Disease by Gagliardi, Stella, Franco, Valentina, Sorrentino, Stefano, Zucca, Susanna, Pandini, Cecilia, Rota, Paola, Bernuzzi, Stefano, Costa, Alfredo, Sinforiani, Elena, Pansarasa, Orietta, Cashman, John R, Cereda, Cristina

“…Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is associated with the most common type of dementia and is characterized by the presence…”
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Therapeutic Salivary Monitoring of Perampanel in Patients with Epilepsy Using a Volumetric Absorptive Microsampling Technique by Palmisani, Michela, Tartara, Elena, Johannessen Landmark, Cecilie, Crema, Francesca, De Giorgis, Valentina, Varesio, Costanza, Fattore, Cinzia, Rota, Paola, Russo, Emilio, Franco, Valentina

“…The objective of this study was to validate a novel assay using the volumetric absorptive microsampling (VAMS) technique combined with liquid chromatography…”
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Melatonin versus Sleep Deprivation for Sleep Induction in Nap Electroencephalography: Protocol for a Prospective Randomized Crossover Trial in Children and Young Adults with Epilepsy by Varesio, Costanza, Franco, Valentina, Pasca, Ludovica, Celario, Massimiliano, Fattore, Cinzia, Fedele, Guido, Rota, Paola, Palmisani, Michela, De Giorgis, Valentina

“…Electroencephalography (EEG) continues to be a pivotal investigation in children with epilepsy, providing diagnostic evidence and supporting syndromic…”
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GM1 Ganglioside Promotes Osteogenic Differentiation of Human Tendon Stem Cells by Pappone, Carlo, Randelli, Pietro, Anastasia, Luigi, Monasky, Michelle M., Rota, Paola, Cirillo, Federica, Menon, Alessandra, Ghiroldi, Andrea, Piccoli, Marco, Creo, Pasquale, Bergante, Sonia, Ciconte, Giuseppe

“…Gangliosides, the sialic acid-conjugated glycosphingolipids present in the lipid rafts, have been recognized as important regulators of cell proliferation,…”
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HIF-1α Directly Controls WNT7A Expression During Myogenesis by Cirillo, Federica, Resmini, Giulia, Angelino, Elia, Ferrara, Michele, Tarantino, Adriana, Piccoli, Marco, Rota, Paola, Ghiroldi, Andrea, Monasky, Michelle M., Ciconte, Giuseppe, Pappone, Carlo, Graziani, Andrea, Anastasia, Luigi

“…Herein we unveil that Hypoxia-inducible factor-1α (HIF-1α) directly regulates WNT7A expression during myogenesis. In fact, chromatin immunoprecipitation (ChiP)…”
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Abstract Mo134: Restoring NaV1.5 Mutant Functionality in Arrhythmia with ManNAc Supplementation by Tarantino, Adriana, Melgari, Dario, Lavota, Ivana, Rota, Paola, Frosio, Anthony, Rivolta, Ilaria, Pappone, Carlo, Anastasia, Luigi

“…Abstract only The SCN5A gene encodes the human cardiac sodium channel NaV1.5, essential for cardiac excitability and action potential propagation. Mutations in…”
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Straightforward access to 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid by Rota, Paola, La Rocca, Paolo, Franco, Valentina, Allevi, Pietro

“…The facile syntheses of previously unreported 2,3- and 3,4-unsaturated derivatives of N-glycolylneuraminic acid are herein described. The procedure involves a…”
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Elucidation of several neglected reactions in the GC-MS identification of sialic acids as heptafluorobutyrates calls for an urgent reassessment of previous claims by Rota, Paola, Anastasia, Luigi, Allevi, Pietro

“…The current analytical protocol used for the GC-MS determination of free or 1,7-lactonized natural sialic acids (Sias), as heptafluorobutyrates, overlooks…”
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