Search Results - "Rota, Giorgia"

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo by Rota, Giorgia, Niogret, Charlène, Dang, Anh Thu, Barros, Cristina Ramon, Fonta, Nicolas Pierre, Alfei, Francesca, Morgado, Leonor, Zehn, Dietmar, Birchmeier, Walter, Vivier, Eric, Guarda, Greta

“…In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the…”
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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells by Niogret, Charlène, Miah, S. M. Shahjahan, Rota, Giorgia, Fonta, Nicolas P., Wang, Haiping, Held, Werner, Birchmeier, Walter, Sexl, Veronica, Yang, Wentian, Vivier, Eric, Ho, Ping-Chih, Brossay, Laurent, Guarda, Greta

“…The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells…”
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NLRC5 exclusively transactivates MHC class I and related genes through a distinctive SXY module by Ludigs, Kristina, Seguín-Estévez, Queralt, Lemeille, Sylvain, Ferrero, Isabel, Rota, Giorgia, Chelbi, Sonia, Mattmann, Chantal, MacDonald, H Robson, Reith, Walter, Guarda, Greta

“…MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a…”
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NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions by Ludigs, Kristina, Jandus, Camilla, Utzschneider, Daniel T., Staehli, Francesco, Bessoles, Stéphanie, Dang, Anh Thu, Rota, Giorgia, Castro, Wilson, Zehn, Dietmar, Vivier, Eric, Held, Werner, Romero, Pedro, Guarda, Greta

“…NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI expression particularly in T cells. Recent evidence highlights an…”
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VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding by Lanitis, Evripidis, Kosti, Paris, Ronet, Catherine, Cribioli, Elisabetta, Rota, Giorgia, Spill, Aodrenn, Reichenbach, Patrick, Zoete, Vincent, Dangaj Laniti, Denarda, Coukos, George, Irving, Melita

“…BackgroundThe adoptive transfer of chimeric antigen receptor (CAR)-T cells has emerged as a potent immunotherapy against some hematological malignancies but…”
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Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression by Lanitis, Evripidis, Rota, Giorgia, Kosti, Paris, Ronet, Catherine, Spill, Aodrenn, Seijo, Bili, Romero, Pedro, Dangaj, Denarda, Coukos, George, Irving, Melita

“…Limited clinical benefit has been demonstrated for chimeric antigen receptor (CAR) therapy of solid tumors, but coengineering strategies to generate so-called…”
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The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity by Castro, Wilson, Chelbi, Sonia T., Niogret, Charlène, Ramon-Barros, Cristina, Welten, Suzanne P. M., Osterheld, Kevin, Wang, Haiping, Rota, Giorgia, Morgado, Leonor, Vivier, Eric, Raeber, Miro E., Boyman, Onur, Delorenzi, Mauro, Barras, David, Ho, Ping-Chih, Oxenius, Annette, Guarda, Greta

“…Regulatory factor X 7 (Rfx7) is an uncharacterized transcription factor belonging to a family involved in ciliogenesis and immunity. Here, we found that…”
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Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses by Ventura, Pedro M O, Gakovic, Milica, Fischer, Berenice A, Spinelli, Laura, Rota, Giorgia, Pathak, Shalini, Khameneh, Hanif J, Zenobi, Alessandro, Thomson, Sarah, Birchmeier, Walter, Cantrell, Doreen A, Guarda, Greta

“…Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD‐1. Blockade of PD‐1…”
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Innate receptors for adaptive immunity by Michallet, Marie-Cécile, Rota, Giorgia, Maslowski, Kendle, Guarda, Greta

“…Highlights • PRRs are expressed by cells of the innate, but also of the adaptive immune system. • Certain PRRs endow B and T cells with innate sensing…”
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T Cell Priming by Activated Nlrc5-Deficient Dendritic Cells Is Unaffected despite Partially Reduced MHC Class I Levels by Rota, Giorgia, Ludigs, Kristina, Siegert, Stefanie, Tardivel, Aubry, Morgado, Leonor, Reith, Walter, De Gassart, Aude, Guarda, Greta

“…NLRC5, a member of the NOD-like receptor (NLR) protein family, has recently been characterized as the master transcriptional regulator of MHCI molecules in…”
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FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure by González-Loyola, Alejandra, Bovay, Esther, Kim, Jaeryung, Lozano, Tania Wyss, Sabine, Amélie, Renevey, Francois, Arroz-Madeira, Silvia, Rapin, Alexis, Wypych, Tomasz P, Rota, Giorgia, Durot, Stephan, Velin, Dominique, Marsland, Benjamin, Guarda, Greta, Delorenzi, Mauro, Zamboni, Nicola, Luther, Sanjiv A, Petrova, Tatiana V

“…The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain…”
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SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency by Schmied, Laurent, Luu, Thuy T, Søndergaard, Jonas N, Hald, Sophia H, Meinke, Stephan, Mohammad, Dara K, Singh, Sunitha B, Mayer, Corinna, Perinetti Casoni, Giovanna, Chrobok, Michael, Schlums, Heinrich, Rota, Giorgia, Truong, Hieu M, Westerberg, Lisa S, Guarda, Greta, Alici, Evren, Wagner, Arnika K, Kadri, Nadir, Bryceson, Yenan T, Saeed, Mezida B, Höglund, Petter

“…Natural killer (NK) cells recognize virally infected cells and tumors. NK cell function depends on balanced signaling from activating receptors, recognizing…”
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NLRC5 Exclusively Transactivates MHC Class I and Related Genes through a Distinctive SXY Module: e1005088 by Ludigs, Kristina, Seguín-Estévez, Queralt, Lemeille, Sylvain, Ferrero, Isabel, Rota, Giorgia, Chelbi, Sonia, Mattmann, Chantal, MacDonald, H Robson, Reith, Walter, Guarda, Greta

“…MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) family member CIITA, which is recruited to SXY enhancers of MHCII promoters via a…”
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Shp-2 modulates aspects of T cell exhaustion differently from PD-1 by Rota, Giorgia, Niogret, Charlene, Thu, Dang Anh, Alfei, Francesca, Ramon, Barros Cristina, Morgado, Leonor, Zehn, Dietmar, Birchmeier, Walter, Vivier, Eric, Guarda, Greta

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