Search Results - "Rosten, Patty"

The methyltransferase G9a regulates HoxA9-dependent transcription in AML by Lehnertz, Bernhard, Pabst, Caroline, Su, Le, Miller, Michelle, Liu, Feng, Yi, Lin, Zhang, Regan, Krosl, Jana, Yung, Eric, Kirschner, Jeanette, Rosten, Patty, Underhill, T Michael, Jin, Jian, Hébert, Josée, Sauvageau, Guy, Humphries, R Keith, Rossi, Fabio M

“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
Get full text

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis by Berg, Tobias, Thoene, Silvia, Yap, Damian, Wee, Tracee, Schoeler, Nathalie, Rosten, Patty, Lim, Emilia, Bilenky, Misha, Mungall, Andrew J., Oellerich, Thomas, Lee, Sherry, Lai, Courteney K., Umlandt, Patricia, Salmi, Anisa, Chang, Harry, Yue, Lisa, Lai, David, Cheng, S.-W. Grace, Morin, Ryan D., Hirst, Martin, Serve, Hubert, Marra, Marco A., Morin, Gregg B., Gascoyne, Randy D., Aparicio, Samuel A., Humphries, R. Keith

“…The histone methyltransferase EZH2 is frequently mutated in germinal center–derived diffuse large B-cell lymphoma and follicular lymphoma. To further…”
Get full text

Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion by Miller, Michelle Erin, Rosten, Patty, Lemieux, Madeleine E, Lai, Courteney, Humphries, R Keith

“…Meis1 is recognized as an important transcriptional regulator in hematopoietic development and is strongly implicated in the pathogenesis of leukemia, both as…”
Get full text

Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia by Gurevich, Rhonna M., Rosten, Patty M., Schwieger, Maike, Stocking, Carol, Humphries, R. Keith

“…The NUP98-TOP1 fusion gene is one of 18 distinct translocations identified in acute myeloid leukemia involving the N-terminal portion of the nucleoporin NUP98…”
Get full text

Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development by Gasparetto, Maura, Sekulovic, Sanja, Brocker, Chad, Tang, Patrick, Zakaryan, Anush, Xiang, Ping, Kuchenbauer, Florian, Wen, Maggie, Kasaian, Katayoon, Witty, Marie France, Rosten, Patty, Chen, Ying, Imren, Suzan, Duester, Gregg, Thompson, David C, Humphries, Richard Keith, Vasiliou, Vasilis, Smith, Clay

“…High levels of the aldehyde dehydrogenase isoform ALDH1A1 are expressed in hematopoietic stem cells (HSCs); however, its importance in these cells remains…”
Get full text

Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3 by Argiropoulos, Bob, Yung, Eric, Xiang, Ping, Lo, Chao Yu, Kuchenbauer, Florian, Palmqvist, Lars, Reindl, Carola, Heuser, Michael, Sekulovic, Sanja, Rosten, Patty, Muranyi, Andrew, Goh, Siew-Lee, Featherstone, Mark, Humphries, R. Keith

“…MEIS1 is a three–amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and…”
Get full text

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span by Helgason, C D, Damen, J E, Rosten, P, Grewal, R, Sorensen, P, Chappel, S M, Borowski, A, Jirik, F, Krystal, G, Humphries, R K

“…SHIP is a 145-kD SH2-containing inositol-5-phosphatase widely expressed in hemopoietic cells. It was first identified as a tyrosine phosphoprotein associated…”
Get full text

Ontogeny stage-independent and high-level clonal expansion in vitro of mouse hematopoietic stem cells stimulated by an engineered NUP98-HOX fusion transcription factor by Sekulovic, Sanja, Gasparetto, Maura, Lecault, Véronique, Hoesli, Corinne A., Kent, David G., Rosten, Patty, Wan, Adrian, Brookes, Christy, Hansen, Carl L., Piret, James M., Smith, Clayton, Eaves, Connie J., Humphries, R. Keith

“…Achieving high-level expansion of hematopoietic stem cells (HSCs) in vitro will have an important clinical impact in addition to enabling elucidation of their…”
Get full text

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1 by Pineault, Nicolas, Buske, Christian, Feuring-Buske, Michaela, Abramovich, Carolina, Rosten, Patty, Hogge, Donna E., Aplan, Peter D., Humphries, R. Keith

“…HOX genes, notably members of the HOXA cluster, and HOX cofactors have increasingly been linked to human leukemia. Intriguingly, HOXD13, a member of the HOXD…”
Get full text

Brief Report: Ectopic Expression of Nup98‐HoxA10 Augments Erythroid Differentiation of Human Embryonic Stem Cells by Ji, Junfeng, Risueño, Ruth M., Hong, Seokho, Allan, David, Rosten, Patty, Humphries, Keith, Bhatia, Mickie

“…Hox genes encode highly conserved transcription factors that have been implicated in hematopoietic development and self‐renewal of hematopoietic stem cells…”
Get full text

Characterization Of The Effects Of Mutated EZH2 On Expression and Epigenome In a Mouse Lymphoma Model by Berg, Tobias, Thoene, Silvia, Yap, Damian, Wee, Tracee, Schoeler, Nathalie, Rosten, Patty, Lim, Emilia, Bilenky, Misha, Mungall, Andrew J, Oellerich, Thomas, Umlandt, Patricia, Salmi, Anisa, Chang, Harry, Yue, Lisa, Lai, David, Cheng, Grace, Serve, Hubert, Morin, Ryan D, Hirst, Martin, Marra, Marco A., Morin, Gregg B., Gascoyne, Randy D., Aparicio, Samuel A., Humphries, R. Keith

“…The histone methyl-transferase EZH2 is frequently affected by gain-of-function mutations in germinal-center lymphoma. To further test if these EZH2 mutations…”
Get full text

Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclic D3 by ARGIROPOULOS, Bob, YUNG, Eric, MURANYI, Andrew, GOH, Siew-Lee, FEATHERSTONE, Mark, HUMPHRIES, R. Keith, PING XIANG, CHAO YU LO, KUCHENBAUER, Florian, PALMQVIST, Lars, REINDL, Carola, HEUSER, Michael, SEKULOVIC, Sanja, ROSTEN, Patty

Get full text

Ships ahoy by Krystal, Gerald, Damen, Jacqueline E, Helgason, Cheryl D, Huber, Michael, Hughes, Michael R, Kalesnikoff, Janet, Lam, Vivian, Rosten, Patty, Ware, Mark D, Yew, Sandie, Humphries, R.Keith

“…In 1996 three groups independently cloned a hemopoietic specific, src homology 2-containing inositol 5′-phosphatase which, based on its structure, was called…”
Get full text