Search Results - "Rostalski, Hannah"

Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches by Huber, Nadine, Korhonen, Sonja, Hoffmann, Dorit, Leskelä, Stina, Rostalski, Hannah, Remes, Anne M., Honkakoski, Paavo, Solje, Eino, Haapasalo, Annakaisa

“…Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal neurodegenerative diseases and, to date, no validated diagnostic or prognostic…”
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Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissue by Harwood, Dylan Scott Lykke, Pedersen, Vilde, Bager, Nicolai Schou, Schmidt, Ane Yde, Stannius, Tobias Overlund, Areškevičiūtė, Aušrinė, Josefsen, Knud, Nørøxe, Dorte Schou, Scheie, David, Rostalski, Hannah, Lü, Maya Jeje Schuang, Locallo, Alessio, Lassen, Ulrik, Bagger, Frederik Otzen, Weischenfeldt, Joachim, Heiland, Dieter Henrik, Vitting-Seerup, Kristoffer, Michaelsen, Signe Regner, Kristensen, Bjarne Winther

“…Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and…”
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C9orf72 hexanucleotide repeat expansion leads to altered neuronal and dendritic spine morphology and synaptic dysfunction by Huber, Nadine, Hoffmann, Dorit, Giniatullina, Raisa, Rostalski, Hannah, Leskelä, Stina, Takalo, Mari, Natunen, Teemu, Solje, Eino, Remes, Anne M., Giniatullin, Rashid, Hiltunen, Mikko, Haapasalo, Annakaisa

“…Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of progressive neurodegenerative syndromes. To date, no validated biomarkers or…”
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Astrocytes and Microglia as Potential Contributors to the Pathogenesis of C9orf72 Repeat Expansion-Associated FTLD and ALS by Rostalski, Hannah, Leskelä, Stina, Huber, Nadine, Katisko, Kasper, Cajanus, Antti, Solje, Eino, Marttinen, Mikael, Natunen, Teemu, Remes, Anne M, Hiltunen, Mikko, Haapasalo, Annakaisa

“…Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases with a complex, but often overlapping, genetic…”
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Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models by Wittrahm, Rebekka, Takalo, Mari, Kuulasmaa, Teemu, Mäkinen, Petra M., Mäkinen, Petri, Končarević, Saša, Fartzdinov, Vadim, Selzer, Stefan, Kokkola, Tarja, Antikainen, Leila, Martiskainen, Henna, Kemppainen, Susanna, Marttinen, Mikael, Jeskanen, Heli, Rostalski, Hannah, Rahunen, Eija, Kivipelto, Miia, Ngandu, Tiia, Natunen, Teemu, Lambert, Jean-Charles, Tanzi, Rudolph E., Kim, Doo Yeon, Rauramaa, Tuomas, Herukka, Sanna-Kaisa, Soininen, Hilkka, Laakso, Markku, Pike, Ian, Leinonen, Ville, Haapasalo, Annakaisa, Hiltunen, Mikko

“…The rare A673T variant was the first variant found within the amyloid precursor protein (APP) gene conferring protection against Alzheimer's disease (AD)…”
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FTLD Patient–Derived Fibroblasts Show Defective Mitochondrial Function and Accumulation of p62 by Leskelä, Stina, Hoffmann, Dorit, Rostalski, Hannah, Huber, Nadine, Wittrahm, Rebekka, Hartikainen, Päivi, Korhonen, Ville, Leinonen, Ville, Hiltunen, Mikko, Solje, Eino, Remes, Anne M., Haapasalo, Annakaisa

“…Frontotemporal lobar degeneration (FTLD) is a clinically, genetically, and neuropathologically heterogeneous group of neurodegenerative syndromes, leading to…”
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C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner by Leskelä, Stina, Huber, Nadine, Rostalski, Hannah, Natunen, Teemu, Remes, Anne M, Takalo, Mari, Hiltunen, Mikko, Haapasalo, Annakaisa

“…Dysfunctional autophagy or ubiquitin-proteasome system (UPS) are suggested to underlie abnormal protein aggregation in neurodegenerative diseases…”
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BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci by Rostalski, Hannah, Hietanen, Tomi, Leskelä, Stina, Behánová, Andrea, Abdollahzadeh, Ali, Wittrahm, Rebekka, Mäkinen, Petra, Huber, Nadine, Hoffmann, Dorit, Solje, Eino, Remes, Anne M., Natunen, Teemu, Takalo, Mari, Tohka, Jussi, Hiltunen, Mikko, Haapasalo, Annakaisa

“…Hexanucleotide repeat expansion (HRE) in the chromosome 9 open-reading frame 72 ( C9orf72 ) gene is the most common genetic cause underpinning frontotemporal…”
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Extracellular prolyl oligopeptidase derived from activated microglia is a potential neuroprotection target by Natunen, Teemu A., Gynther, Mikko, Rostalski, Hannah, Jaako, Külli, Jalkanen, Aaro J.

“…Prolyl oligopeptidase (PREP) is an abundant peptidase in the brain and periphery, but its physiological functions are still largely unknown. Recent findings…”
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GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance by Katisko, Kasper, Cajanus, Antti, Huber, Nadine, Jääskeläinen, Olli, Kokkola, Tarja, Kärkkäinen, Virve, Rostalski, Hannah, Hartikainen, Paivi, Koivisto, Anne M, Hannonen, Sanna, Lehtola, Juha-Matti, Korhonen, Ville E, Helisalmi, Seppo, Koivumaa-Honkanen, Heli, Herukka, Sanna-Kaisa, Remes, Anne M, Solje, Eino, Haapasalo, Annakaisa

“…BackgroundFrontotemporal lobar degeneration (FTLD) and primary psychiatric disorders (PPD) are characterised by overlapping clinical features but different…”
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ANGI-08. SPATIAL TRANSCRIPTOMIC COMPARISONS OF GLIOBLASTOMA TISSUE REVEAL UPREGULATION OF NEURODEVELOPMENTAL PATHWAYS AND SYNAPTIC GENES IN INFILTRATING TUMOR CELLS by Harwood, Dylan, Pedersen, Vilde, Bager, Nicolai, Schmidt, Ane, Stannius, Tobias, Areškevičiūtė, Aušrinė, Josefsen, Knud, Nørøxe, Dorte, Scheie, David, Rostalski, Hannah, Lü, Maya, Locallo, Alessio, Lassen, Ulrik, Bagger, Frederik, Weischenfeldt, Joachim, Heiland, Dieter, Vitting-Seerup, Kristoffer, Michaelsen, Signe, Kristensen, Bjarne

“…Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, chemotherapy, and…”
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A Novel Genetic Marker for the C9orf72 Repeat Expansion in the Finnish Population by Rostalski, Hannah, Korhonen, Ville, Kuulasmaa, Teemu, Solje, Eino, Krüger, Johanna, Gen, Finn, Kaivola, Karri, Eide, Per Kristian, Lambert, Jean-Charles, Julkunen, Valtteri, Tienari, Pentti J, Remes, Anne M, Leinonen, Ville, Hiltunen, Mikko, Haapasalo, Annakaisa

“…C9orf72 repeat expansion (C9exp) is the most common genetic cause underlying frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS)…”
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Frontotemporal dementia: a conference report from the 2nd FinFTD Symposium by Hoffmann, Dorit, Huber, Nadine, Leskelä, Stina, Rostalski, Hannah, Solje, Eino, Remes, Anne M, Haapasalo, Annakaisa

“…The 2nd FinFTD Symposium was held on 13 September 2019, in Kuopio, Finland, and attracted 80 attendees from six different countries. The program, spanning from…”
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Abstract 1144: Glioblastoma cells increase expression of neurodevelopmental programs and synaptic connectivity in the tumor periphery by Harwood, Dylan, Pedersen, Vilde, Bager, Nicolai S., Schmidt, Ane Y., Stannius, Tobias O., Areskeviciute, Ausrine, Josefsen, Knud, Nørøxe, Dorte S., Scheie, David, Rostalski, Hannah E., Lassen, Ulrik, Bagger, Frederik O., Weischenfeldt, Joachim, Heiland, Dieter H., Vitting-Seerup, Kristoffer, Michaelsen, Signe R., Kristensen, Bjarne W.

“…Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by…”
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