A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds: Uncovering Its Dual Antifungal and Hypoglycemic Properties

Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical...

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Bibliographic Details
Published in:	Pharmaceutics Vol. 15; no. 3; p. 781
Main Authors:	Cotabarren, Juliana, Ozón, Brenda, Claver, Santiago, Geier, Florencia, Rossotti, Martina, Garcia-Pardo, Javier, Obregón, Walter David
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-02-2023 MDPI
Subjects:	antifungal Antifungal agents bioactive compound bioactive peptide Biosynthesis Candida albicans Capsicum annuum L Chemical properties Experiments Fungal infections Fungi Health aspects Hypoglycemic agents Peptides Pharmaceutical industry protease Protease inhibitors Proteins Seeds Sweet peppers Testing Virulence Argentina Candida albicans protease antifungal protease inhibitor phytocystatin natural product trypsin inhibitor Capsicum annuum L bioactive compound bioactive peptide
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Summary:	Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an active area of research in the pharmaceutical industry. In this study, we purified and characterized a trypsin protease inhibitor obtained from Yellow Bell Pepper ( L.) seeds. The inhibitor not only showed potent and specific activity against the pathogenic fungus , but was also found to be non-toxic against human cells. Furthermore, this inhibitor is unique in that it also inhibits α-1,4-glucosidase, positioning it as one of the first plant-derived protease inhibitors with dual biological activity. This exciting discovery opens new avenues for the development of this inhibitor as a promising antifungal agent and highlights the potential of plant-derived protease inhibitors as a rich source for the discovery of novel multifunctional bioactive molecules.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	1999-4923 1999-4923
DOI:	10.3390/pharmaceutics15030781