Search Results - "Rossmueller, Gregor"

Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies by Sajko, Sara, Skeens, Erin, Schinagl, Alexander, Ferhat, Maroua, Mirkina, Irina, Mayer, Julia, Rossmueller, Gregor, Thiele, Michael, Lisi, George P.

“…MIF is a ubiquitous protein involved in proinflammatory processes, which undergoes an oxidation-driven conformational change to oxidized (ox)MIF. We…”
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The newly engineered monoclonal antibody ON104, targeting the oxidized Macrophage Migration Inhibitory Factor (oxMIF), ameliorates clinical and histopathological signs of collagen-induced arthritis by Ferhat, Maroua, Mangano, Katia, Mirkina, Irina, Mayer, Julia, Rossmueller, Gregor, Schinagl, Alexander, Kerschbaumer, Randolf, Nicoletti, Ferdinando, Thiele, Michael, Landlinger, Christine

“…Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic inflammatory cytokine that emerged as a pivotal regulator in the pathogenesis of several…”
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Preclinical Evaluation of ON203, A Novel Bioengineered mAb Targeting Oxidized Macrophage Migration Inhibitory Factor as an Anticancer Therapeutic by Rossmueller, Gregor, Mirkina, Irina, Maurer, Barbara, Hoeld, Verena, Mayer, Julia, Thiele, Michael, Kerschbaumer, Randolf J, Schinagl, Alexander

“…High levels of macrophage migration inhibitory factor (MIF) in patients with cancer are associated with poor prognosis. Its redox-dependent conformational…”
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Abstract 313: Novel bioengineered monoclonal antibodies targeting oxidized macrophage migration inhibitory factor as anti-cancer therapeutics and companion diagnostics by Schinagl, Alexander, Thiele, Michael, Mirkina, Irina, Rossmueller, Gregor, Tarazona, Alejandro A. Puchol, Kerschbaumer, Randolf J.

“…Abstract Background: Macrophage Migration Inhibitory Factor (MIF) has been described as a pleiotropic cytokine known to exacerbate tumor growth (Chesney and…”
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