Search Results - "Rossmeisl, Martin"

Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: A key to lean phenotype by Flachs, Pavel, Rossmeisl, Martin, Kuda, Ondrej, Kopecky, Jan

“…We are facing a revival of the strategy to counteract obesity and associated metabolic disorders by inducing thermogenesis mediated by mitochondrial uncoupling…”
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Omega‐3 phospholipids and obesity‐associated NAFLD: Potential mechanisms and therapeutic perspectives by Mitrovic, Marko, Sistilli, Gabriella, Horakova, Olga, Rossmeisl, Martin

“…Prevalence of non‐alcoholic fatty liver disease (NAFLD) increases in line with obesity and type 2 diabetes, and there is no approved drug therapy…”
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Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport by Horakova, Olga, Kroupova, Petra, Bardova, Kristina, Buresova, Jana, Janovska, Petra, Kopecky, Jan, Rossmeisl, Martin

“…Metformin is currently the most prescribed drug for treatment of type 2 diabetes mellitus in humans. It has been well established that long-term treatment with…”
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Metabolomics atlas of oral 13C-glucose tolerance test in mice by Lopes, Magno, Brejchova, Kristyna, Riecan, Martin, Novakova, Michaela, Rossmeisl, Martin, Cajka, Tomas, Kuda, Ondrej

“…Glucose tolerance represents a complex phenotype in which many tissues play important roles and interact to regulate metabolic homeostasis. Here, we perform an…”
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Levels of palmitic acid ester of hydroxystearic acid (PAHSA) are reduced in the breast milk of obese mothers by Brezinova, Marie, Kuda, Ondrej, Hansikova, Jana, Rombaldova, Martina, Balas, Laurence, Bardova, Kristina, Durand, Thierry, Rossmeisl, Martin, Cerna, Marcela, Stranak, Zbynek, Kopecky, Jan

“…To achieve optimal development of a newborn, breastfeeding is extensively recommended, but little is known about the role of non-nutritive bioactive milk…”
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Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids by Rossmeisl, Martin, Jilkova, Zuzana Macek, Kuda, Ondrej, Jelenik, Tomas, Medrikova, Dasa, Stankova, Barbora, Kristinsson, Björn, Haraldsson, Gudmundur G, Svensen, Harald, Stoknes, Iren, Sjövall, Peter, Magnusson, Ylva, Balvers, Michiel G J, Verhoeckx, Kitty C M, Tvrzicka, Eva, Bryhn, Morten, Kopecky, Jan

“…n-3 polyunsaturated fatty acids, namely docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), reduce the risk of cardiovascular disease and can…”
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Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity by Sistilli, Gabriella, Kalendova, Veronika, Cajka, Tomas, Irodenko, Illaria, Bardova, Kristina, Oseeva, Marina, Zacek, Petr, Kroupova, Petra, Horakova, Olga, Lackner, Karoline, Gastaldelli, Amalia, Kuda, Ondrej, Kopecky, Jan, Rossmeisl, Martin

“…Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs)…”
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Omega-3 Phospholipids from Krill Oil Enhance Intestinal Fatty Acid Oxidation More Effectively than Omega-3 Triacylglycerols in High-Fat Diet-Fed Obese Mice by Kroupova, Petra, van Schothorst, Evert M, Keijer, Jaap, Bunschoten, Annelies, Vodicka, Martin, Irodenko, Ilaria, Oseeva, Marina, Zacek, Petr, Kopecky, Jan, Rossmeisl, Martin, Horakova, Olga

“…Antisteatotic effects of omega-3 fatty acids (Omega-3) in obese rodents seem to vary depending on the lipid form of their administration. Whether these effects…”
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Omega-3 phospholipids from fish suppress hepatic steatosis by integrated inhibition of biosynthetic pathways in dietary obese mice by Rossmeisl, Martin, Medrikova, Dasa, van Schothorst, Evert M., Pavlisova, Jana, Kuda, Ondrej, Hensler, Michal, Bardova, Kristina, Flachs, Pavel, Stankova, Barbora, Vecka, Marek, Tvrzicka, Eva, Zak, Ales, Keijer, Jaap, Kopecky, Jan

“…Non-alcoholic fatty liver disease (NAFLD) accompanies obesity and insulin resistance. Recent meta-analysis suggested omega-3 polyunsaturated fatty acids DHA…”
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n-3 PUFA: bioavailability and modulation of adipose tissue function by Kopecky, Jan, Rossmeisl, Martin, Flachs, Pavel, Kuda, Ondrej, Brauner, Petr, Jilkova, Zuzana, Stankova, Barbora, Tvrzicka, Eva, Bryhn, Morten

“…Adipose tissue has a key role in the development of metabolic syndrome (MS), which includes obesity, type 2 diabetes, dyslipidaemia, hypertension and other…”
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Reduced Number of Adipose Lineage and Endothelial Cells in Epididymal fat in Response to Omega-3 PUFA in Mice Fed High-Fat Diet by Adamcova, Katerina, Horakova, Olga, Bardova, Kristina, Janovska, Petra, Brezinova, Marie, Kuda, Ondrej, Rossmeisl, Martin, Kopecky, Jan

“…We found previously that white adipose tissue (WAT) hyperplasia in obese mice was limited by dietary omega-3 polyunsaturated fatty acids (omega-3 PUFA). Here…”
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Additive Effects of Omega-3 Fatty Acids and Thiazolidinediones in Mice Fed a High-Fat Diet: Triacylglycerol/Fatty Acid Cycling in Adipose Tissue by Bardova, Kristina, Funda, Jiri, Pohl, Radek, Cajka, Tomas, Hensler, Michal, Kuda, Ondrej, Janovska, Petra, Adamcova, Katerina, Irodenko, Ilaria, Lenkova, Lucie, Zouhar, Petr, Horakova, Olga, Flachs, Pavel, Rossmeisl, Martin, Colca, Jerry, Kopecky, Jan

“…Long-chain n-3 polyunsaturated fatty acids (Omega-3) and anti-diabetic drugs thiazolidinediones (TZDs) exhibit additive effects in counteraction of dietary…”
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Plasma Acylcarnitines and Amino Acid Levels As an Early Complex Biomarker of Propensity to High-Fat Diet-Induced Obesity in Mice by Horakova, Olga, Hansikova, Jana, Bardova, Kristina, Gardlo, Alzbeta, Rombaldova, Martina, Kuda, Ondrej, Rossmeisl, Martin, Kopecky, Jan

“…Obesity is associated with insulin resistance and impaired glucose tolerance, which represent characteristic features of the metabolic syndrome. Development of…”
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Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat by Funda, Jiří, Villena, Josep A, Bardova, Kristina, Adamcova, Katerina, Irodenko, Illaria, Flachs, Pavel, Jedlickova, Ivana, Haasova, Eliska, Rossmeisl, Martin, Kopecky, Jan, Janovska, Petra

“…Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as…”
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Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones by Benova, Andrea, Ferencakova, Michaela, Bardova, Kristina, Funda, Jiri, Prochazka, Jan, Spoutil, Frantisek, Cajka, Tomas, Dzubanova, Martina, Balcaen, Tim, Kerckhofs, Greet, Willekens, Wouter, van Lenthe, G. Harry, Alquicer, Glenda, Pecinova, Alena, Mracek, Tomas, Horakova, Olga, Rossmeisl, Martin, Kopecky, Jan, Tencerova, Michaela

“…The use of thiazolidinediones (TZDs) as insulin sensitizers has been shown to have side effects including increased accumulation of bone marrow adipocytes…”
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Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle by Janovska, Petra, Zouhar, Petr, Bardova, Kristina, Otahal, Jakub, Vrbacky, Marek, Mracek, Tomas, Adamcova, Katerina, Lenkova, Lucie, Funda, Jiri, Cajka, Tomas, Drahota, Zdenek, Stanic, Sara, Rustan, Arild C., Horakova, Olga, Houstek, Josef, Rossmeisl, Martin, Kopecky, Jan

“…Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response…”
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Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding by Horakova, Olga, Sistilli, Gabriella, Kalendova, Veronika, Bardova, Kristina, Mitrovic, Marko, Cajka, Tomas, Irodenko, Ilaria, Janovska, Petra, Lackner, Karoline, Kopecky, Jan, Rossmeisl, Martin

“…Non-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with…”
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A pyrexic effect of FGF21 independent of energy expenditure and UCP1 by Zouhar, Petr, Janovska, Petra, Stanic, Sara, Bardova, Kristina, Funda, Jiri, Haberlova, Blanka, Andersen, Birgitte, Rossmeisl, Martin, Cannon, Barbara, Kopecky, Jan, Nedergaard, Jan

“…Administration of FGF21 to mice reduces body weight and increases body temperature. The increase in body temperature is generally interpreted as hyperthermia,…”
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Chronic n-3 fatty acid intake enhances insulin response to oral glucose and elevates GLP-1 in high-fat diet-fed obese mice by Pavlisova, Jana, Horakova, Olga, Kalendova, Veronika, Buresova, Jana, Bardova, Kristina, Holendova, Blanka, Plecita-Hlavata, Lydie, Vackova, Sarka, Windrichova, Jindra, Topolcan, Ondrej, Kopecky, Jan, Rossmeisl, Martin

“…n-3 polyunsaturated fatty acids (PUFA) can exert beneficial effects on glucose homeostasis, especially in obese rodents. Gut incretin hormones regulate glucose…”
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Omega-3 PUFA of marine origin limit diet-induced obesity in mice by reducing cellularity of adipose tissue by Ruzickova, J, Rossmeisl, M, Prazak, T, Flachs, P, Sponarova, J, Vecka, M, Tvrzicka, E, Bryhn, M, Kopecky, J

“…Omega‐3 PUFA of marine origin reduce adiposity in animals fed a high‐fat diet. Our aim was to learn whether EPA and DHA could limit development of obesity and…”
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