ADENOSINE INCREASES INTERLEUKIN 6 RELEASE AND DECREASES TUMOUR NECROSIS FACTOR RELEASE FROM RAT ADRENAL ZONA GLOMERULOSA CELLS, OVARIAN CELLS, ANTERIOR PITUITARY CELLS AND PERITONEAL MACROPHAGES

Adenosine modifies interleukin 6 (IL-6) and tumour necrosis factor (TNF) release from immune tissues. Because adenosine alters endocrine function and endocrine cells secrete cytokines, its effects on IL-6 and TNF release from rat adrenals, ovaries, and anterior pituitaries were compared with its eff...

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Published in:	Cytokine (Philadelphia, Pa.) Vol. 9; no. 3; pp. 187 - 198
Main Authors:	Ritchie, Paul K., Spangelo, Bryan L., Krzymowski, David K., Rossiter, Tamra B., Kurth, Emily, Judd, Allan M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-03-1997
Subjects:	Adenosine - analogs & derivatives Adenosine - pharmacology adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology angiotensin II Animals Antineoplastic Agents - pharmacology Cells, Cultured endotoxin Female interleukin 1 Interleukin-6 - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Ovary - drug effects Ovary - metabolism Phenethylamines - pharmacology Pituitary Gland, Anterior - drug effects Pituitary Gland, Anterior - metabolism Purinergic P1 Receptor Agonists Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha - metabolism tumour necrosis factor Xanthines - pharmacology Zona Glomerulosa - drug effects Zona Glomerulosa - metabolism tumour necrosis factor adrenocorticotropic hormone angiotensin II interleukin 1 endotoxin
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Summary:	Adenosine modifies interleukin 6 (IL-6) and tumour necrosis factor (TNF) release from immune tissues. Because adenosine alters endocrine function and endocrine cells secrete cytokines, its effects on IL-6 and TNF release from rat adrenals, ovaries, and anterior pituitaries were compared with its effects on cytokine release from rat peritoneal macrophages. Adenosine increased basal IL-6 release and decreased basal TNF release from adrenal zona glomerulosa and zone fasciculata/reticularis cells. IL-6 and TNF release from zona glomerulosa cells was greater (20×) than that of other adrenal cells. An A 2agonist modified adrenal IL-6 and TNF release at lower concentrations than an A 1agonist. Adenosine augmented adrenal IL-6 release stimulated by endotoxin (LPS), interleukin 1β (IL-1β), adrenocorticotrophic hormone, and angiotensin II. LPS- and IL-1β-stimulated adrenal TNF release was inhibited by adenosine. Adenosine increased IL-6 release and inhibited TNF release from ovarian cells. Anterior pituitary cells released IL-6, but no detectable TNF. Adenosine, via A 2receptors, stimulated IL-6 secretion from these cells. Peritoneal macrophage IL-6 release was increased and TNF release decreased by adenosine. Thus, in immune and endocrine tissues, adenosine increases IL-6 release, but inhibits TNF release.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1043-4666 1096-0023
DOI:	10.1006/cyto.1996.0153