Search Results - "Rossiter, Lana M"

Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of U.S. Commercial Cigarettes by Edwards, Selvin H, Rossiter, Lana M, Taylor, Kenneth M, Holman, Matthew R, Zhang, Liqin, Ding, Yan S, Watson, Clifford H

“…Tobacco-specific nitrosamines (TSNAs) are N-nitroso-derivatives of pyridine-alkaloids (e.g., nicotine) present in tobacco and cigarette smoke. Two TSNAs,…”
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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease by Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W

“…Verubecestat 3 (MK-8931), a diaryl amide-substituted 3-imino-1,2,4-thiadiazinane 1,1-dioxide derivative, is a high-affinity β-site amyloid precursor protein…”
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A Concise Palladium-Catalyzed Carboamination Route to (±)-Tylophorine by Rossiter, Lana M, Slater, Meagan L, Giessert, Rachel E, Sakwa, Samuel A, Herr, R. Jason

“…A total synthesis of the racemic natural product tylophorine [(±)-1] has been demonstrated using the palladium-catalyzed carboamination method developed by…”
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Discovery of BMS-641988, a Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer by Balog, Aaron, Rampulla, Richard, Martin, Gregory S, Krystek, Stanley R, Attar, Ricardo, Dell-John, Janet, DiMarco, John D, Fairfax, David, Gougoutas, Jack, Holst, Christian L, Nation, Andrew, Rizzo, Cheryl, Rossiter, Lana M, Schweizer, Liang, Shan, Weifang, Spergel, Steven, Spires, Thomas, Cornelius, Georgia, Gottardis, Marco, Trainor, George, Vite, Gregory D, Salvati, Mark E

“…BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for…”
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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases by Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D

“…Structure−activity relationships in a series of 4-[1H-indazol-5-ylamino]pyrrolo[2,1-f][1,2,4]triazine-6-carbamates identified dual human epidermal growth…”
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Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists by Xiao, Hai-Yun, Balog, Aaron, Attar, Ricardo M., Fairfax, David, Fleming, Linda B., Holst, Christian L., Martin, Gregory S., Rossiter, Lana M., Chen, Jing, Cvjic, Mary-Ellen, Dell-John, Janet, Geng, Jieping, Gottardis, Marco M., Han, Wen-Ching, Nation, Andrew, Obermeier, Mary, Rizzo, Cheryl A., Schweizer, Liang, Spires, Thomas, Shan, Weifang, Gavai, Ashvinikumar, Salvati, Mark E., Vite, Gregory

“…A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these…”
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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1 H -indazol-5-ylamino]-5-methylpyrrolo[2,1- f ][1,2,4]triazin-6-yl]carbamic Acid, (3 S )-3-Morpholinylmethyl Ester (BMS-599626), a Selective and Orally Efficacious Inhibitor of Human Epidermal Growth Factor Receptor 1 and 2 Kinases by Gavai, Ashvinikumar V., Fink, Brian E., Fairfax, David J., Martin, Gregory S., Rossiter, Lana M., Holst, Christian L., Kim, Soong-Hoon, Leavitt, Kenneth J., Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M., Tokarski, John S., Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y., Wong, Tai W., Vite, Gregory D.

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Design and synthesis of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.02,6]undec4-yl]-2-trifluoromethyl-benzonitriles as androgen receptor antagonists by XIAO, Hai-Yun, BALOG, Aaron, DELL-JOHN, Janet, JIEPING GENG, GOTTARDIS, Marco M, HAN, Wen-Ching, NATION, Andrew, OBERMEIER, Mary, RIZZO, Cheryl A, SCHWEIZER, Liang, SPIRES, Thomas, WEIFANG SHAN, ATTAR, Ricardo M, GAVAI, Ashvinikumar, SALVATI, Mark E, VITE, Gregory, FAIRFAX, David, FLEMING, Linda B, HOLST, Christian L, MARTIN, Gregory S, ROSSITER, Lana M, JING CHEN, CVJIC, Mary-Ellen

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