Search Results - "Rossier, M. F."

Genetic polymorphisms and drug interactions modulating CYP2D6 and CYP3A activities have a major effect on oxycodone analgesic efficacy and safety by Samer, CF, Daali, Y, Wagner, M, Hopfgartner, G, Eap, CB, Rebsamen, MC, Rossier, MF, Hochstrasser, D, Dayer, P, Desmeules, JA

“…Background and purpose:  The major drug‐metabolizing enzymes for the oxidation of oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the…”
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The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone by Samer, CF, Daali, Y, Wagner, M, Hopfgartner, G, Eap, CB, Rebsamen, MC, Rossier, MF, Hochstrasser, D, Dayer, P, Desmeules, JA

“…Background and purpose:  There is high interindividual variability in the activity of drug‐metabolizing enzymes catalysing the oxidation of oxycodone…”
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The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction by Rebsamen, M C, Desmeules, J, Daali, Y, Chiappe, A, Diemand, A, Rey, C, Chabert, J, Dayer, P, Hochstrasser, D, Rossier, M F

“…Polymorphisms of the cytochrome P450 2D6 ( CYP2D6 ) gene affecting enzyme activity are involved in interindividual variability in drug efficiency/toxicity…”
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Subcellular distribution of the calcium-storing inositol 1,4,5-trisphosphate-sensitive organelle in rat liver : possible linkage to the plasma membrane through the actin microfilaments by ROSSIER, M. F, BIRD, G. S. J, PUTNEY, J. W

“…The role of Ins(1,4,5)P3 in the mobilization of Ca2+ from intracellular stores of non-muscle cells has been extensively demonstrated; however, the nature of…”
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The role of tyrosine kinases in capacitative calcium influx-mediated aldosterone production in bovine adrenal zona glomerulosa cells by Aptel, HB, Burnay, MM, Rossier, MF, Capponi, AM

“…In adrenal glomerulosa cells, the stimulation of aldosterone biosynthesis by angiotensin II (Ang II) involves the activation of a capacitative Ca(2+) influx…”
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Activation of Ca2+ entry into acinar cells by a non-phosphorylatable inositol trisphosphate by BIRD, G. S. J, ROSSIER, M. F, HUGHES, A. R, SHEARS, S. B, ARMSTRONG, D. L, PUTNEY, J. W

“…In many cell types, receptor activation of phosphoinositidase C results in an initial release of intracellular Ca2+ stores followed by sustained Ca2+ entry…”
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Sinusoidal oscillations in intracellular calcium requiring negative feedback by protein kinase C by G S Bird, M F Rossier, J F Obie, J W Putney, Jr

“…Stimulation of mouse lacrimal acinar cells with submaximal concentrations of the muscarinic agonist, methacholine, resulted in an increase in intracellular…”
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Blocking T-type calcium channels with tetrandrine inhibits steroidogenesis in bovine adrenal glomerulosa cells by Rossier, M F, Python, C P, Capponi, A M, Schlegel, W, Kwan, C Y, Vallotton, M B

“…Tetrandrine, an alkaloid extracted from a Chinese medicinal herb traditionally used in hypertension treatment, inhibited aldosterone production induced in…”
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Confinement of intracellular calcium signaling in secretory and steroidogenic cells by ROSSIER, M. F

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Overexpression of an alpha(1H) (Ca(v)3.2) T-type calcium channel during neuroendocrine differentiation of human prostate cancer cells by Mariot, P., Vanoverberghe, K., Lalevee, Nathalie, Rossier, M. F., Prevarskaya, N.

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Thapsigargin inhibits voltage-activated calcium channels in adrenal glomerulosa cells by ROSSIER, M. F, PYTHON, C. P, BURNAY, M. M, SCHLEGEL, W, VALLOTTON, M. B, CAPPONI, A. M

“…Thapsigargin, an inhibitor of the microsomal Ca2+ pumps, has been extensively used to study the intracellular Ca2+ pool participating in the generation of the…”
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Role of the capacitative calcium influx in the activation of steroidogenesis by angiotensin-II in adrenal glomerulosa cells by Burnay, M M, Python, C P, Vallotton, M B, Capponi, A M, Rossier, M F

“…Angiotensin-II (AngII)-induced Ca2+ influx in adrenal glomerulosa cells, a signal necessary for the stimulation of steroidogenesis by the hormone, is believed…”
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The identity of the calcium-storing, inositol 1,4,5-trisphosphate-sensitive organelle in non-muscle cells: calciosome, endoplasmic reticulum ... or both? by Rossier, M F, Putney, Jr, J W

“…Although the initial phase of receptor-mediated Ca2+ signaling, involving Ca2+ release from intracellular stores by inositol 1,4,5-trisphosphate, is relatively…”
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Calcium stimulates steroidogenesis in permeabilized bovine adrenal cortical cells by Capponi, A M, Rossier, M F, Davies, E, Vallotton, M B

“…The effect of Ca2+ on steroid production was examined in electropermeabilized bovine adrenal zona glomerulosa and fasciculata cells. The cells were superfused…”
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Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes by LALEVEE, Nathalie, REBSAMEN, Michela C, BARRERE-LEMAIRE, Stéphanie, PERRIER, Emeline, NARGEOT, Joël, BENITAH, Jean-Pierre, ROSSIER, Michel F

“…Although aldosterone has been implicated in the pathogenesis of cardiac hypertrophy and heart failure, its cellular mechanism of action on cardiomyocyte…”
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The Inositol 1,4,5-Trisphosphate-binding Site in Adrenal Cortical Cells Is Distinct from the Endoplasmic Reticulum by Rossier, M F, Capponi, A M, Vallotton, M B

“…The distribution of binding sites for the calcium-mobilizing second messenger inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) was investigated in subcellular…”
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Peripheral-type benzodiazepines inhibit calcium channels and aldosterone production in adrenal glomerulosa cells by Python, C P, Rossier, M F, Vallotton, M B, Capponi, A M

“…Angiotensin-II (Ang-II), K+, and ACTH are important stimulators of aldosterone secretion that require Ca2+ influx to be active. However, Ang-II and K+ are…”
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Potassium-angiotensin interplay in the regulation of aldosterone biosynthesis by Vallotton, M B, Rossier, M F, Capponi, A M

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Inhibitory and stimulatory effects of phorbol ester on vasopressin-induced cellular responses in cultured rat aortic smooth muscle cells by CHARDONNENS, D, LANG, U, ROSSIER, M. F, CAPPONI, A. M, VALLOTTON, M. B

“…In rat aortic smooth muscle cells, vasopressin (AVP) induces prostacyclin (PGI2) production, probably as the consequence of phospholipase C activation. Our…”
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Aldosterone increases T-type calcium currents in human adrenocarcinoma (H295R) cells by inducing channel expression by Lesouhaitier, O, Chiappe, A, Rossier, M F

“…In adrenal glomerulosa cells, low-threshold voltage-activated (T-type) calcium channels are known to play a crucial role in coupling physiological variations…”
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