Search Results - "Rossi, Susana G"
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Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-2009)“…Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a…”
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2
Biglycan is an extracellular MuSK binding protein important for synapse stability
Published in The Journal of neuroscience (15-02-2012)“…The receptor tyrosine kinase MuSK is indispensable for nerve-muscle synapse formation and maintenance. MuSK is necessary for prepatterning of the endplate zone…”
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Translational Regulation of Acetylcholinesterase by the RNA-binding Protein Pumilio-2 at the Neuromuscular Synapse
Published in The Journal of biological chemistry (21-10-2011)“…Acetylcholinesterase (AChE) is highly expressed at sites of nerve-muscle contact where it is regulated at both the transcriptional and post-transcriptional…”
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Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice
Published in Nature neuroscience (01-02-2002)“…The collagen-tailed form of acetylcholinesterase (AChE) is concentrated at the vertebrate neuromuscular junction (NMJ), where it is responsible for rapidly…”
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Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool
Published in Human molecular genetics (01-10-2013)Get full text
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Localization of the Calcitonin Gene-related Peptide Receptor Complex at the Vertebrate Neuromuscular Junction and Its Role in Regulating Acetylcholinesterase Expression
Published in The Journal of biological chemistry (04-07-2003)“…The calcitonin gene-related peptide (CGRP) is released by motor neurons where it exerts both short and long term effects on skeletal muscle fibers. In…”
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7
Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool
Published in Human molecular genetics (01-10-2013)“…With age, muscle mass and integrity are progressively lost leaving the elderly frail, weak and unable to independently care for themselves. Defined as…”
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Rescue and Stabilization of Acetylcholinesterase in Skeletal Muscle by N-terminal Peptides Derived from the Noncatalytic Subunits
Published in The Journal of biological chemistry (21-08-2015)“…The vast majority of newly synthesized acetylcholinesterase (AChE) molecules do not assemble into catalytically active oligomeric forms and are rapidly…”
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Local Control of Acetylcholinesterase Gene Expression in Multinucleated Skeletal Muscle Fibers: Individual Nuclei Respond to Signals from the Overlying Plasma Membrane
Published in The Journal of neuroscience (01-02-2000)“…Nuclei in multinucleated skeletal muscle fibers are capable of expressing different sets of muscle-specific genes depending on their locations within the…”
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10
Transplantation of Quail Collagen-Tailed Acetylcholinesterase Molecules onto the Frog Neuromuscular Synapse
Published in The Journal of cell biology (27-01-1997)“…The highly organized pattern of acetylcholinesterase (AChE) molecules attached to the basal lamina of the neuromuscular junction (NMJ) suggests the existence…”
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The Dystroglycan Complex Is Necessary for Stabilization of Acetylcholine Receptor Clusters at Neuromuscular Junctions and Formation of the Synaptic Basement Membrane
Published in The Journal of cell biology (05-02-2001)“…The dystrophin-associated protein (DAP) complex spans the sarcolemmal membrane linking the cytoskeleton to the basement membrane surrounding each myofiber…”
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12
Targeting acetylcholinesterase to the neuromuscular synapse
Published in Chemico-biological interactions (15-12-2005)“…The collagen-tailed form of acetylcholinesterase (ColQ-AChE) is the major if not unique form of the enzyme associated with the specialized synaptic basal…”
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Transient Interactions between Collagen-tailed Acetylcholinesterase and Sulfated Proteoglycans Prior to Immobilization on the Extracellular Matrix
Published in The Journal of biological chemistry (26-01-1996)“…Heparin is capable of solubilizing a subset of collagen-tailed (A ) acetylcholinesterase (AChE) molecules from skeletal muscle fibers, but cannot detach AChE…”
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CORRECTION: Increased Muscle PGC-1α Expression Protects from Sarcopenia and Metabolic Disease during Aging
Published in Proceedings of the National Academy of Sciences - PNAS (04-11-2014)Get full text
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15
Cell Surface Acetylcholinesterase Molecules on Multinucleated Myotubes Are Clustered over the Nucleus of Origin
Published in The Journal of cell biology (01-12-1992)“…Multinucleated skeletal muscle fibers are compartmentalized with respect to the expression and organization of several intracellular and cell surface proteins…”
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Absence of α-Syntrophin Leads to Structurally Aberrant Neuromuscular Synapses Deficient in Utrophin
Published in The Journal of cell biology (18-09-2000)“…The syntrophins are a family of structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin,…”
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Increased muscle PGC-1[alpha] expression protects from sarcopenia and metabolic disease during aging
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-2009)“…Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a…”
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Journal Article -
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RETRACTED: Increased muscle PGC-1α expression protects from sarcopenia and metabolic disease during aging
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-2009)“…Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a…”
Get full text
Journal Article -
19
Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-2009)“…Aging is a major risk factor for metabolic disease and loss of skeletal muscle mass and strength, a condition known as sarcopenia. Both conditions present a…”
Get full text
Journal Article -
20
Absence of alpha-syntrophin leads to structually aberrant neuromuscular synapses deficient in utrophin
Published in The Journal of cell biology (18-09-2000)“…The syntrophins are a family of structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin,…”
Get full text
Journal Article