Search Results - "Rossi, Ferdinand"

Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor by Bosbach, Benedikt, Rossi, Ferdinand, Yozgat, Yasemin, Loo, Jennifer, Zhang, Jennifer Q., Berrozpe, Georgina, Warpinski, Katherine, Ehlers, Imke, Veach, Darren, Kwok, Andrew, Manova, Katia, Antonescu, Cristina R., DeMatteo, Ronald P., Besmer, Peter

“…Gastrointestinal stromal tumors (GISTs) predominantly harbor activating mutations in the receptor tyrosine kinase KIT. To genetically dissect in vivo the…”
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KIT oncogene inhibition drives intratumoral macrophage M2 polarization by Cavnar, Michael J, Zeng, Shan, Kim, Teresa S, Sorenson, Eric C, Ocuin, Lee M, Balachandran, Vinod P, Seifert, Adrian M, Greer, Jonathan B, Popow, Rachel, Crawley, Megan H, Cohen, Noah A, Green, Benjamin L, Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R, DeMatteo, Ronald P

“…Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulation of TAMs is under intense investigation because they are…”
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Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor by Vitiello, Gerardo A, Medina, Benjamin D, Zeng, Shan, Bowler, Timothy G, Zhang, Jennifer Q, Loo, Jennifer K, Param, Nesteene J, Liu, Mengyuan, Moral, Alec J, Zhao, Julia N, Rossi, Ferdinand, Antonescu, Cristina R, Balachandran, Vinod P, Cross, Justin R, DeMatteo, Ronald P

“…Imatinib dramatically reduces gastrointestinal stromal tumor (GIST) F-FDG uptake, providing an early indicator of treatment response. Despite decreased glucose…”
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Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor by KIM, Teresa S, CAVNAR, Michael J, VEACH, Darren R, KU, Anson T, ROSSI, Ferdinand, BESMER, Peter, ANTONESCU, Cristina R, SHAN ZENG, DEMATTEO, Ronald P, COHEN, Noah A, SORENSON, Eric C, GREER, Jonathan B, SEIFERT, Adrian M, CRAWLEY, Megan H, GREEN, Benjamin L, POPOW, Rachel, PILLARSETTY, Nagavarakishore

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and a model of targeted molecular therapy. GIST depends on oncogenic KIT signaling and…”
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Oncogenic Kit Signaling and Therapeutic Intervention in a Mouse Model of Gastrointestinal Stromal Tumor by Rossi, Ferdinand, Ehlers, Imke, Agosti, Valter, Socci, Nicholas D., Viale, Agnes, Sommer, Gunhild, Yozgat, Yasemin, Manova, Katia, Antonescu, Cristina R., Besmer, Peter

“…Kit receptor-activating mutations are critical in the pathogenesis of gastrointestinal stromal tumors (GIST). We investigated mechanisms of oncogenic Kit…”
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Gastrointestinal Stromal Tumors in a Mouse Model by Targeted Mutation of the Kit Receptor Tyrosine Kinase by Sommer, Gunhild, Agosti, Valter, Ehlers, Imke, Rossi, Ferdinand, Corbacioglu, Selim, Farkas, Judith, Moore, Malcolm, Manova, Katia, Antonescu, Cristina R., Besmer, Peter

“…Oncogenic Kit mutations are found in somatic gastrointestinal (GI) stromal tumors (GISTs) and mastocytosis. A mouse model for the study of constitutive…”
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Changes in the Structure and Function of ICC Networks in ICC Hyperplasia and Gastrointestinal Stromal Tumors by Kwon, Joong Goo, Hwang, Sung Jin, Hennig, Grant W, Bayguinov, Yulia, McCann, Conor, Chen, Hui, Rossi, Ferdinand, Besmer, Peter, Sanders, Kenton M, Ward, Sean M

“…Background & Aims Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase c-kit. Approximately 90% of GISTs have gain-of-function…”
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Colony Stimulating Factor Receptor 1 (CSF1R) Inhibition Impairs Liver Regeneration by Santamaria-Barria, Juan A., MD, Greer, Jonathan B., MD, Zeng, Shan, MD, PhD, Seifert, Adrian M., MD, Cohen, Noah A., MD, Beckman, Michael J., MD, Rossi, Ferdinand, PhD, Crawley, Megan H., BS, Green, Benjamin L., BS, DeMatteo, Ronald P., MD, FACS

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Imatinib resistance and microcytic erythrocytosis in a Kitⱽ⁵⁵⁸Δ;ᵀ⁶⁶⁹ᴵ/⁺ gatekeeper-mutant mouse model of gastrointestinal stromal tumor by Bosbach, Benedikt, Deshpande, Shayu, Rossi, Ferdinand, Shieh, Jae-Hung, Sommer, Gunhild, de Stanchina, Elisa, Veach, Darren R, Scandura, Joseph M, Manova-Todorova, Katia, Moore, Malcolm A. S, Antonescu, Cristina R, Besmer, Peter

“…Most gastrointestinal stromal tumors (GISTs) harbor a gain-of-function mutation in the Kit receptor. GIST patients treated with the tyrosine kinase inhibitor…”
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Specific phosphorylation of SR proteins by mammalian DNA topoisomerase I by Rossi, Ferdinand, Labourier, Emmanuel, Forné, Thierry, Divita, Gilles, Derancourt, Jean, Riou, Jean François, Antoine, Etienne, Cathala, Guy, Brunel, Claude, Tazi, Jamal

“…Several metazoan splicing factors are characterized by ribonucleoprotein (RNP) consensus sequences and arginine-serine repeats (RS domain) which are essential…”
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FGF Signaling Targets the pRb-Related p107 and p130 Proteins to Induce Chondrocyte Growth Arrest by Laplantine, Emmanuel, Rossi, Ferdinand, Sahni, Malika, Basilico, Claudio, Cobrinik, David

“…Unregulated FGF signaling affects endochondral ossification and long bone growth, causing several genetic forms of human dwarfism. One major mechanism by which…”
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p107 and p130 Coordinately Regulate Proliferation, Cbfa1 Expression, and Hypertrophic Differentiation during Endochondral Bone Development by Rossi, Ferdinand, MacLean, Helen E., Yuan, Wei, Francis, Richard O., Semenova, Ekaterina, Lin, Carol S., Kronenberg, Henry M., Cobrinik, David

“…During endochondral bone development, both the chondrogenic differentiation of mesenchyme and the hypertrophic differentiation of chondrocytes coincide with…”
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Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing by Tazi, Jamal, Kornstädt, Ute, Rossi, Ferdinand, Jeanteur, Philippe, Cathala, Guy, Brunel, Claude, Lührmann, Reinhard

“…The U1 small nuclear ribonucleoprotein (snRNP) particle is one of the Sm class of snRNPs essential for splicing of precursor messenger RNA. Mammalian U1 snRNP…”
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Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido by Balachandran, Vinod P, Cavnar, Michael J, Zeng, Shan, Bamboat, Zubin M, Ocuin, Lee M, Obaid, Hebroon, Sorenson, Eric C, Popow, Rachel, Ariyan, Charlotte, Rossi, Ferdinand, Besmer, Peter, Guo, Tianhua, Antonescu, Cristina R, Taguchi, Takahiro, Yuan, Jianda, Wolchok, Jedd D, Allison, James P, DeMatteo, Ronald P

“…Imatinib has been proposed as a therapy for gastrointestinal stromal tumors, owing to its side effects on KIT, a kinase often mutated in this type of tumor…”
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Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor by Vitiello, Gerardo A, Bowler, Timothy G, Liu, Mengyuan, Medina, Benjamin D, Zhang, Jennifer Q, Param, Nesteene J, Loo, Jennifer K, Goldfeder, Rachel L, Chibon, Frederic, Rossi, Ferdinand, Zeng, Shan, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma, frequently characterized by an oncogenic mutation in the KIT or platelet-derived growth…”
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PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors by Seifert, Adrian M, Zeng, Shan, Zhang, Jennifer Q, Kim, Teresa S, Cohen, Noah A, Beckman, Michael J, Medina, Benjamin D, Maltbaek, Joanna H, Loo, Jennifer K, Crawley, Megan H, Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R, DeMatteo, Ronald P

“…Tyrosine kinase inhibitors are effective in gastrointestinal stromal tumors (GISTs) but often are of transient benefit as resistance commonly develops…”
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Myosin light chain kinase inhibition potentiates the anti-tumor effects of avapritinib in PDGFRA D842V-mutant gastrointestinal stromal tumor by Rossi, Ferdinand, Liu, Mengyuan, Tieniber, Andrew, Etherington, Mark S., Hanna, Andrew, Vitiello, Gerardo A., Param, Nesteene J., Do, Kevin, Wang, Laura, Antonescu, Cristina R., Zeng, Shan, Zhang, Jennifer Q., DeMatteo, Ronald P.

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Myosin Light-Chain Kinase Inhibition Potentiates the Antitumor Effects of Avapritinib in PDGFRA D842V-Mutant Gastrointestinal Stromal Tumor by Rossi, Ferdinand, Liu, Mengyuan, Tieniber, Andrew, Etherington, Mark S, Hanna, Andrew, Vitiello, Gerardo A, Param, Nesteene J, Do, Kevin, Wang, Laura, Antonescu, Cristina R, Zeng, Shan, Zhang, Jennifer Q, DeMatteo, Ronald P

“…To create an in vivo model of PDGFRA D842V-mutant gastrointestinal stromal tumor (GIST) and identify the mechanism of tumor persistence following avapritinib…”
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Oncogenic kinase inhibition limits Batf3-dependent dendritic cell development and antitumor immunity by Medina, Benjamin D, Liu, Mengyuan, Vitiello, Gerardo A, Seifert, Adrian M, Zeng, Shan, Bowler, Timothy, Zhang, Jennifer Q, Cavnar, Michael J, Loo, Jennifer K, Param, Nesteene J, Maltbaek, Joanna H, Rossi, Ferdinand, Balachandran, Vinod, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is driven by an activating mutation in the proto-oncogene. Using a mouse model of GIST and human specimens, we show that…”
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The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor by Zhang, Jennifer Q., Bosbach, Benedikt, Loo, Jennifer K., Vitiello, Gerardo A., Zeng, Shan, Seifert, Adrian M., Medina, Benjamin D., Param, Nesteene J., Maltbaek, Joanna H., Rossi, Ferdinand, Antonescu, Cristina R., Besmer, Peter, DeMatteo, Ronald P.

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and arises in the gastrointestinal tract. Most GISTs are caused by activating mutations…”
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