Search Results - "Rossi, Antonio"
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Alectinib for ALK-positive non-small-cell lung cancer
Published in Expert review of clinical pharmacology (02-08-2016)“…Anaplastic lymphoma kinase (ALK) rearrangements are present in about 5% of advanced non-small-cell lung cancer (NSCLC) patients. Despite the initial response,…”
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Immunotherapy in Small Cell Lung Cancer
Published in European Medical Journal (Chelmsford, England) (13-06-2019)“…Small-cell lung cancer (SCLC) is extremely sensitive to standard treatments, including conventional cytotoxic chemotherapies and radiotherapy, and has poor…”
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3
Bone and connective tissue disorders caused by defects in glycosaminoglycan biosynthesis: a panoramic view
Published in The FEBS journal (01-08-2019)“…Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides that constitute the carbohydrate moiety covalently attached to the protein core…”
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Carboplatin- or Cisplatin-Based Chemotherapy in First-Line Treatment of Small-Cell Lung Cancer: The COCIS Meta-Analysis of Individual Patient Data
Published in Journal of clinical oncology (10-05-2012)“…Since treatment efficacy of cisplatin- or carboplatin-based chemotherapy in the first-line treatment of small-cell lung cancer (SCLC) remains contentious, a…”
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B7-H3/CD276 and small-cell lung cancer: What's new?
Published in Translational oncology (01-01-2024)“…•B7-H3, also known as CD276, is a member of the B7 family overexpressed in tumor tissues, including SCLC.•The overexpression of B7-H3 is often correlated with…”
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Radiographic and ultrasonographic findings of seminal vesiculitis with nonmineral stones in a guinea pig: Case report
Published in Veterinary radiology & ultrasound (30-10-2024)“…This case report refers to a 1-year-old Guinea pig showing signs of anorexia and antipain posture. On abdominal radiography, five rounded mineral opaque…”
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The proteostasis guardian HSF1 directs the transcription of its paralog and interactor HSF2 during proteasome dysfunction
Published in Cellular and molecular life sciences : CMLS (01-02-2021)“…Protein homeostasis is essential for life in eukaryotes. Organisms respond to proteotoxic stress by activating heat shock transcription factors (HSFs), which…”
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Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection
Published in Nature metabolism (01-06-2021)“…Patients with coronavirus disease 2019 (COVID-19) are reported to have a greater prevalence of hyperglycaemia. Cytokine release as a consequence of severe…”
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Pharmacotherapeutic options for treating adverse effects of Cisplatin chemotherapy
Published in Expert opinion on pharmacotherapy (03-03-2016)“…Cisplatin is widely used in the treatment of several tumors such as lung, ovarian and testicular cancer with different degrees of effectiveness, and its use is…”
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Six versus fewer planned cycles of first-line platinum-based chemotherapy for non-small-cell lung cancer: a systematic review and meta-analysis of individual patient data
Published in The lancet oncology (01-10-2014)“…Summary Background Platinum-based chemotherapy is the standard first-line treatment for patients with advanced non-small-cell lung cancer. However, the optimum…”
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The Impact of Diabetes Mellitus on Cardiovascular Risk Onset in Children and Adolescents
Published in International journal of molecular sciences (12-07-2020)“…The prevalence of diabetes mellitus is rising among children and adolescents worldwide. Cardiovascular diseases are the main cause of morbidity and mortality…”
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Skeletal Dysplasias Caused by Sulfation Defects
Published in International journal of molecular sciences (14-04-2020)“…Proteoglycans (PGs) are macromolecules present on the cell surface and in the extracellular matrix that confer specific mechanical, biochemical, and physical…”
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EGFR-Mutant Non-small Cell Lung Cancer: State-of-the-Art and Future Perspectives
Published in European Medical Journal (Chelmsford, England) (05-12-2022)“…EGFR mutations are the first identified targetable driver alterations in advanced non-small cell lung cancer (NSCLC), for which specific epidermal growth…”
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4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion
Published in Biochimica et biophysica acta. Molecular basis of disease (01-05-2018)“…The clinical phenotype in osteogenesis imperfecta (OI) is attributed to the dominant negative function of mutant type I collagen molecules in the extracellular…”
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Clinical and ultrasound variables for early diagnosis of septic acute kidney injury in bitches with pyometra
Published in Scientific reports (02-06-2020)“…The aetiology of septic acute kidney injury (AKI) is not completely elucidated. Early identification of AKI in septic patients is considered to improve…”
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Dermatophyte Resistance to Antifungal Drugs: Mechanisms and Prospectus
Published in Frontiers in microbiology (29-05-2018)“…Dermatophytes comprise pathogenic fungi that have a high affinity for the keratinized structures present in nails, skin, and hair, causing superficial…”
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IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies
Published in Blood (10-01-2019)“…Proteasome inhibitors (PI) are extensively used for the therapy of multiple myeloma (MM) and mantle cell lymphoma. However, patients continuously relapse or…”
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The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta
Published in Human molecular genetics (01-08-2017)“…Classical osteogenesis imperfecta (OI) is a bone disease caused by type I collagen mutations and characterized by bone fragility, frequent fractures in absence…”
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B7-H3/CD276 Inhibitors: Is There Room for the Treatment of Metastatic Non-Small Cell Lung Cancer?
Published in International journal of molecular sciences (16-12-2022)“…The striking clinical outcomes of antibody-based immunotherapy, through the inhibitors of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and the…”
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Extracellular Vesicles From the Dermatophyte Trichophyton interdigitale Modulate Macrophage and Keratinocyte Functions
Published in Frontiers in immunology (09-10-2018)“…The release of biomolecules critically affects all pathogens and their establishment of diseases. For the export of several biomolecules in diverse species,…”
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