Search Results - "Rosshart, Stephan P"

Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance by Rosshart, Stephan P., Vassallo, Brian G., Angeletti, Davide, Hutchinson, Diane S., Morgan, Andrew P., Takeda, Kazuyo, Hickman, Heather D., McCulloch, John A., Badger, Jonathan H., Ajami, Nadim J., Trinchieri, Giorgio, Pardo-Manuel de Villena, Fernando, Yewdell, Jonathan W., Rehermann, Barbara

“…Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living…”
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Laboratory mice born to wild mice have natural microbiota and model human immune responses by Rosshart, Stephan P, Herz, Jasmin, Vassallo, Brian G, Hunter, Ashli, Wall, Morgan K, Badger, Jonathan H, McCulloch, John A, Anastasakis, Dimitrios G, Sarshad, Aishe A, Leonardi, Irina, Collins, Nicholas, Blatter, Joshua A, Han, Seong-Ji, Tamoutounour, Samira, Potapova, Svetlana, Foster St Claire, Mark B, Yuan, Wuxing, Sen, Shurjo K, Dreier, Matthew S, Hild, Benedikt, Hafner, Markus, Wang, David, Iliev, Iliyan D, Belkaid, Yasmine, Trinchieri, Giorgio, Rehermann, Barbara

“…Laboratory mouse studies are paramount for understanding basic biological phenomena but also have limitations. These include conflicting results caused by…”
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Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair by Linehan, Jonathan L., Harrison, Oliver J., Han, Seong-Ji, Byrd, Allyson L., Vujkovic-Cvijin, Ivan, Villarino, Alejandro V., Sen, Shurjo K., Shaik, Jahangheer, Smelkinson, Margery, Tamoutounour, Samira, Collins, Nicholas, Bouladoux, Nicolas, Dzutsev, Amiran, Rosshart, Stephan P., Arbuckle, Jesse H., Wang, Chyung-Ru, Kristie, Thomas M., Rehermann, Barbara, Trinchieri, Giorgio, Brenchley, Jason M., O’Shea, John J., Belkaid, Yasmine

“…Mammalian barrier surfaces are constitutively colonized by numerous microorganisms. We explored how the microbiota was sensed by the immune system and the…”
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Discovery of several thousand highly diverse circular DNA viruses by Tisza, Michael J, Pastrana, Diana V, Welch, Nicole L, Stewart, Brittany, Peretti, Alberto, Starrett, Gabriel J, Pang, Yuk-Ying S, Krishnamurthy, Siddharth R, Pesavento, Patricia A, McDermott, David H, Murphy, Philip M, Whited, Jessica L, Miller, Bess, Brenchley, Jason, Rosshart, Stephan P, Rehermann, Barbara, Doorbar, John, Ta'ala, Blake A, Pletnikova, Olga, Troncoso, Juan C, Resnick, Susan M, Bolduc, Ben, Sullivan, Matthew B, Varsani, Arvind, Segall, Anca M, Buck, Christopher B

“…Although millions of distinct virus species likely exist, only approximately 9000 are catalogued in GenBank's RefSeq database. We selectively enriched for the…”
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Impact of High Salt-Intake on a Natural Gut Ecosystem in Wildling Mice by Cardilli, Alessio, Hamad, Ibrahim, Dyczko, Aleksandra, Thijs, Sofie, Vangronsveld, Jaco, Müller, Dominik N, Rosshart, Stephan P, Kleinewietfeld, Markus

“…The mammalian holobiont harbors a complex and interdependent mutualistic gut bacterial community. Shifts in the composition of this bacterial consortium are…”
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The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives by Avery, Ellen G., Bartolomaeus, Hendrik, Maifeld, Andras, Marko, Lajos, Wiig, Helge, Wilck, Nicola, Rosshart, Stephan P., Forslund, Sofia K., Müller, Dominik N.

“…The pathogenesis of hypertension is known to involve a diverse range of contributing factors including genetic, environmental, hormonal, hemodynamic and…”
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The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin‐Deficient Mice by Mann, Jasmin, Runge, Solveig, Schell, Christoph, Gräwe, Katja, Thoulass, Gudrun, Lao, Jessica, Ammann, Sandra, Grün, Sarah, König, Christoph, Berger, Sarah A., Hild, Benedikt, Aichele, Peter, Rosshart, Stephan P., Ehl, Stephan

“…ABSTRACT Primary hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome caused by inborn errors of cytotoxicity. Patients…”
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Keratinocyte-intrinsic MHCII expression controls microbiota-induced Th1 cell responses by Tamoutounour, Samira, Han, Seong-Ji, Deckers, Julie, Constantinides, Michael G., Hurabielle, Charlotte, Harrison, Oliver J., Bouladoux, Nicolas, Linehan, Jonathan L., Link, Verena M., Vujkovic-Cvijin, Ivan, Perez-Chaparro, Paula Juliana, Rosshart, Stephan P., Rehermann, Barbara, Lazarevic, Vanja, Belkaid, Yasmine

“…The cross-talk between the microbiota and the immune system plays a fundamental role in the control of host physiology. However, the tissue-specific factors…”
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Gut-to-brain spreading of pathology in synucleinopathies: A focus on molecular signalling mediators by Schmitt, Verena, Masanetz, Rebecca Katharina, Weidenfeller, Martin, Ebbinghaus, Lara Savannah, Süß, Patrick, Rosshart, Stephan P., von Hörsten, Stephan, Zunke, Friederike, Winkler, Jürgen, Xiang, Wei

“…Synucleinopathies are a group of neurodegenerative disorders, classically characterized by the accumulation of aggregated alpha synuclein (aSyn) in the central…”
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A facility for laboratory mice with a natural microbiome at Charité – Universitätsmedizin Berlin by Drude, Natascha, Nagel-Riedasch, Stefan, Rosshart, Stephan P., Diefenbach, Andreas, Diederich, Kai, Duerr, Claudia U., Harms, Christoph, Heppner, Frank, Kolesnichenko, Marina, Lewejohann, Lars, Mall, Marcus A., Müller, Dominik, Opitz, Bastian, Rosshart, Stephan P., Schönfelder, Gilbert, Tölch, Ulf, Willimsky, Gerald, Jordan, Stefan

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Systemic toxoplasma infection triggers a long-term defect in the generation and function of naive T lymphocytes by Kugler, David G, Flomerfelt, Francis A, Costa, Diego L, Laky, Karen, Kamenyeva, Olena, Mittelstadt, Paul R, Gress, Ronald E, Rosshart, Stephan P, Rehermann, Barbara, Ashwell, Jonathan D, Sher, Alan, Jankovic, Dragana

“…Because antigen-stimulated naive T cells either die as effectors or enter the activated/memory pool, continuous egress of new T lymphocytes from thymus is…”
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Neonatal exposure to a wild-derived microbiome protects mice against diet-induced obesity by Hild, Benedikt, Dreier, Matthew S., Oh, Ji Hoon, McCulloch, John A., Badger, Jonathan H., Guo, Juen, Thefaine, Claire E., Umarova, Regina, Hall, Kevin D., Gavrilova, Oksana, Rosshart, Stephan P., Trinchieri, Giorgio, Rehermann, Barbara

“…Obesity and its consequences are among the greatest challenges in healthcare. The gut microbiome is recognized as a key factor in the pathogenesis of obesity…”
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R2d2 Drives Selfish Sweeps in the House Mouse by Didion, John P, Morgan, Andrew P, Yadgary, Liran, Bell, Timothy A, McMullan, Rachel C, Ortiz de Solorzano, Lydia, Britton-Davidian, Janice, Bult, Carol J, Campbell, Karl J, Castiglia, Riccardo, Ching, Yung-Hao, Chunco, Amanda J, Crowley, James J, Chesler, Elissa J, Förster, Daniel W, French, John E, Gabriel, Sofia I, Gatti, Daniel M, Garland, Jr, Theodore, Giagia-Athanasopoulou, Eva B, Giménez, Mabel D, Grize, Sofia A, Gündüz, İslam, Holmes, Andrew, Hauffe, Heidi C, Herman, Jeremy S, Holt, James M, Hua, Kunjie, Jolley, Wesley J, Lindholm, Anna K, López-Fuster, María J, Mitsainas, George, da Luz Mathias, Maria, McMillan, Leonard, Ramalhinho, Maria da Graça Morgado, Rehermann, Barbara, Rosshart, Stephan P, Searle, Jeremy B, Shiao, Meng-Shin, Solano, Emanuela, Svenson, Karen L, Thomas-Laemont, Patricia, Threadgill, David W, Ventura, Jacint, Weinstock, George M, Pomp, Daniel, Churchill, Gary A, Pardo-Manuel de Villena, Fernando

“…A selective sweep is the result of strong positive selection driving newly occurring or standing genetic variants to fixation, and can dramatically alter the…”
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Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host-microbiome homeostasis by Bülck, Cynthia, Nyström, Elisabeth E L, Koudelka, Tomas, Mannbar-Frahm, Michael, Andresen, Gerrit, Radhouani, Mariem, Tran, Florian, Scharfenberg, Franka, Schrell, Friederike, Armbrust, Fred, Dahlke, Eileen, Zhao, Bei, Vervaeke, Alex, Theilig, Franziska, Rosenstiel, Philip, Starkl, Philipp, Rosshart, Stephan P, Fickenscher, Helmut, Tholey, Andreas, Hansson, Gunnar C, Becker-Pauly, Christoph

“…The metalloproteases meprin α and meprin β are highly expressed in the healthy gut but significantly decreased in inflammatory bowel disease, implicating a…”
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Human resident liver myeloid cells protect against metabolic stress in obesity by Barreby, Emelie, Strunz, Benedikt, Nock, Sebastian, Naudet, Léa, Shen, Joanne X., Johansson, Helene, Sönnerborg, Isabella, Ma, Junjie, Urgard, Egon, Pallett, Laura J., Hu, Yizhou, Fardellas, Achilleas, Azzimato, Valerio, Vankova, Ana, Levi, Laura, Morgantini, Cecilia, Maini, Mala K., Stål, Per, Rosshart, Stephan P., Coquet, Jonathan M., Nowak, Greg, Näslund, Erik, Lauschke, Volker M., Ellis, Ewa, Björkström, Niklas K., Chen, Ping, Aouadi, Myriam

“…Although multiple populations of macrophages have been described in the human liver, their function and turnover in patients with obesity at high risk of…”
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Impact of High Salt-Intake on a Natural Gut Ecosystem in IWildling/I Mice by Cardilli, Alessio, Hamad, Ibrahim, Dyczko, Aleksandra, Thijs, Sofie, Vangronsveld, Jaco, Müller, Dominik N, Rosshart, Stephan P, Kleinewietfeld, Markus

“…The mammalian holobiont harbors a complex and interdependent mutualistic gut bacterial community. Shifts in the composition of this bacterial consortium are…”
Get full text