Search Results - "Rossetti, Thomas"

On-demand male contraception via acute inhibition of soluble adenylyl cyclase by Balbach, Melanie, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Ritagliati, Carla, Myers, Robert W., Huggins, David J., Steegborn, Clemens, Miranda, Ileana C., Meinke, Peter T., Buck, Jochen, Levin, Lonny R.

“…Nearly half of all pregnancies are unintended; thus, existing family planning options are inadequate. For men, the only choices are condoms and vasectomy, and…”
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Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization by Balbach, Melanie, Ghanem, Lubna, Rossetti, Thomas, Kaur, Navpreet, Ritagliati, Carla, Ferreira, Jacob, Krapf, Dario, Puga Molina, Lis C, Santi, Celia Maria, Hansen, Jan Niklas, Wachten, Dagmar, Fushimi, Makoto, Meinke, Peter T, Buck, Jochen, Levin, Lonny R

“…Abstract Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for male fertility in mice and humans. In mice, ex vivo studies…”
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Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential by Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

“…In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these…”
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Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential by Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W, Meinke, Peter T, Levin, Lonny R, Buck, Jochen

“…[This corrects the article DOI: 10.3389/fphys.2022.1013845.]…”
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Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates by Miller, Michael, Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Balbach, Melanie, Kaur, Navpreet, Levin, Lonny R., Buck, Jochen, Kehr, Maria, Coquille, Sandrine, van den Heuvel, Joop, Steegborn, Clemens, Fushimi, Makoto, Finkin-Groner, Efrat, Myers, Robert W., Kargman, Stacia, Liverton, Nigel J., Huggins, David J., Meinke, Peter T.

“…Soluble adenylyl cyclase (sAC: ADCY10) is an enzyme involved in intracellular signaling. Inhibition of sAC has potential therapeutic utility in a number of…”
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Optimizing Small Molecule Inhibitors of Soluble Adenylyl Cyclase (sAC) for Use as Male Contraceptives by Rossetti, Thomas K

“…Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that plays an important role in a wide variety of signal transduction pathways. The…”
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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation by Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

“…Free energy perturbation is a computational technique that can be used to predict how small changes to an inhibitor structure will affect the binding free…”
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Addition to “Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation” by Sun, Shan, Fushimi, Makoto, Rossetti, Thomas, Kaur, Navpreet, Ferreira, Jacob, Miller, Michael, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Levin, Lonny R., Buck, Jochen, Myers, Robert W., Kargman, Stacia, Liverton, Nigel, Meinke, Peter T., Huggins, David J.

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Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs by Rumian, Nicole L., Brown, Carolyn Nicole, Hendry-Hofer, Tara B., Rossetti, Thomas, Orfila, James E., Tullis, Jonathan E., Dwoskin, Linda P., Buonarati, Olivia R., Lisman, John E., Quillinan, Nidia, Herson, Paco S., Bebarta, Vikhyat S., Bayer, K. Ulrich

“…The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a central regulator of learning and memory, which poses a problem for targeting it therapeutically…”
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Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) by Fushimi, Makoto, Buck, Hannes, Balbach, Melanie, Gorovyy, Anna, Ferreira, Jacob, Rossetti, Thomas, Kaur, Navpreet, Levin, Lonny R, Buck, Jochen, Quast, Jonathan, van den Heuvel, Joop, Steegborn, Clemens, Finkin-Groner, Efrat, Kargman, Stacia, Michino, Mayako, Foley, Michael A, Miller, Michael, Liverton, Nigel J, Huggins, David J, Meinke, Peter T

“…Soluble adenylyl cyclase (sAC) has gained attention as a potential therapeutic target given the role of this enzyme in intracellular signaling. We describe…”
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