Search Results - "Rosser, Anne E"

Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development by Keefe, Francesca, Monzón-Sandoval, Jimena, Rosser, Anne E, Webber, Caleb, Li, Meng

“…Inhibitory GABAergic interneurons originate in the embryonic medial ganglionic eminence (MGE) and control network activity in the neocortex. Dysfunction of…”
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Activin A directs striatal projection neuron differentiation of human pluripotent stem cells by Arber, Charles, Precious, Sophie V, Cambray, Serafí, Risner-Janiczek, Jessica R, Kelly, Claire, Noakes, Zoe, Fjodorova, Marija, Heuer, Andreas, Ungless, Mark A, Rodríguez, Tristan A, Rosser, Anne E, Dunnett, Stephen B, Li, Meng

“…The efficient generation of striatal neurons from human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) is fundamental for realising…”
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Challenges for taking primary and stem cells into clinical neurotransplantation trials for neurodegenerative disease by Dunnett, Stephen B, Rosser, Anne E

“…Abstract We review the first generations of clinical trials of novel cell therapies applied to a range of neurodegenerative diseases in the context of…”
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Excessive response to provocation rather than disinhibition mediates irritable behaviour in Huntington's disease by McLauchlan, Duncan James, Linden, David E J, Rosser, Anne E

“…Irritable and impulsive behaviour are common in Huntington's disease (HD: an autosomal dominant disorder causing degeneration in cortico-striatal networks)…”
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Protocol for a randomised controlled unblinded feasibility trial of HD-DRUM: a rhythmic movement training application for cognitive and motor symptoms in people with Huntington’s disease by Ioakeimidis, Vasileios, Busse, Monica, Drew, Cheney J G, Pallmann, Philip, Watson, Guy B, Jones, Derek, Palombo, Marco, Schubert, Robin, Rosser, Anne E, Metzler-Baddeley, Claudia

“…IntroductionHuntington’s disease (HD) is an inherited neurodegenerative disease causing progressive cognitive and motor decline, largely due to basal ganglia…”
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Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model by Harrison, David J., Busse, Monica, Openshaw, Rebecca, Rosser, Anne E., Dunnett, Stephen B., Brooks, Simon P.

“…Huntington's disease (HD) is a neurodegenerative disease caused by a mutation within the huntingtin gene that induces degeneration within the striatal nuclei,…”
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Is the Immunological Response a Bottleneck for Cell Therapy in Neurodegenerative Diseases? by Salado-Manzano, Cristina, Perpiña, Unai, Straccia, Marco, Molina-Ruiz, Francisco J, Cozzi, Emanuele, Rosser, Anne E, Canals, Josep M

“…Neurodegenerative disorders such as Parkinson's (PD) and Huntington's disease (HD) are characterized by a selective detrimental impact on neurons in a specific…”
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Fetal calcium regulates branching morphogenesis in the developing human and mouse lung: involvement of voltage-gated calcium channels by Brennan, Sarah C, Finney, Brenda A, Lazarou, Maria, Rosser, Anne E, Scherf, Caroline, Adriaensen, Dirk, Kemp, Paul J, Riccardi, Daniela

“…Airway branching morphogenesis in utero is essential for optimal postnatal lung function. In the fetus, branching morphogenesis occurs during the…”
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Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease by Casella, Chiara, Kleban, Elena, Rosser, Anne E., Coulthard, Elizabeth, Rickards, Hugh, Fasano, Fabrizio, Metzler-Baddeley, Claudia, Jones, Derek K.

“…•Gradient-echo data were acquired from premanifest HD patients in the callosum at 7 T.•Reproducibility of multi-compartment analysis across callosal areas was…”
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Robust MR-based approaches to quantifying white matter structure and structure/function alterations in Huntington's disease by Steventon, Jessica J., Trueman, Rebecca C., Rosser, Anne E., Jones, Derek K.

“…•A pipeline is presented to address HD-related confounds in diffusion MRI data.•CSF contamination affected the sensitivity to detect white matter alterations…”
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Rethinking Functional Outcome Measures: The Development of a Novel Upper Limb Token Transfer Test to Assess Basal Ganglia Dysfunction by Clinch, Susanne P, Busse, Monica, Lelos, Mariah J, Rosser, Anne E

“…The basal ganglia are implicated in a wide range of motor, cognitive and behavioral activities required for normal function. This region is predominantly…”
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Do foetal transplant studies continue to be justified in Huntington's disease? by Bartley, Oliver J M, Lelos, Mariah J, Gray, William P, Rosser, Anne E

“…Early CNS transplantation studies used foetal derived cell products to provide a foundation of evidence for functional recovery in preclinical studies and…”
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The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse by Harrison, David J., Roberton, Victoria H., Vinh, Ngoc-Nga, Brooks, Simon P., Dunnett, Stephen B., Rosser, Anne E.

“…Huntington's disease (HD) is a progressive neurodegenerative disease in which striatal medium spiny neurons (MSNs) are lost. Neuronal replacement therapies aim…”
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Dopaminergic Progenitors Derived From Epiblast Stem Cells Function Similarly to Primary VM-Derived Progenitors When Transplanted Into a Parkinson's Disease Model by Precious, Sophie V, Smith, Gaynor A, Heuer, Andreas, Jaeger, Ines, Lane, Emma L, Dunnett, Stephen B, Li, Meng, Kelly, Claire M, Rosser, Anne E

“…Neural transplantation in neurodegenerative diseases such as Parkinson's disease (PD) offers to replace cells lost during the progression of the disease…”
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Differentiation of pluripotent stem cells into striatal projection neurons: a pure MSN fate may not be sufficient by Reddington, Amy E, Rosser, Anne E, Dunnett, Stephen B

“…Huntington's disease (HD) is an autosomal dominant inherited disorder leading to the loss inter alia of DARPP-32 positive medium spiny projection neurons…”
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Huntington’s disease age at motor onset is modified by the tandem hexamer repeat in TCERG1 by Lobanov, Sergey V., McAllister, Branduff, McDade-Kumar, Mia, Landwehrmeyer, G. Bernhard, Orth, Michael, Rosser, Anne E., Paulsen, Jane S., Lee, Jong-Min, MacDonald, Marcy E., Gusella, James F., Long, Jeffrey D., Ryten, Mina, Williams, Nigel M., Holmans, Peter, Massey, Thomas H., Jones, Lesley

“…Huntington’s disease is caused by an expanded CAG tract in HTT . The length of the CAG tract accounts for over half the variance in age at onset of disease,…”
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A randomised feasibility study of computerised cognitive training as a therapeutic intervention for people with Huntington's disease (CogTrainHD) by Yhnell, Emma, Furby, Hannah, Lowe, Rachel S, Brookes-Howell, Lucy C, Drew, Cheney J G, Playle, Rebecca, Watson, Gareth, Metzler-Baddeley, Claudia, Rosser, Anne E, Busse, Monica E

“…Huntington's disease (HD) is associated with a range of cognitive deficits including problems with executive function. In the absence of a disease modifying…”
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Direct Comparison of Rat- and Human-Derived Ganglionic Eminence Tissue Grafts on Motor Function by Lelos, Mariah J, Roberton, Victoria H, Vinh, Ngoc-Nga, Harrison, Carl, Eriksen, Peter, Torres, Eduardo M, Clinch, Susanne P, Rosser, Anne E, Dunnett, Stephen B

“…Huntington's disease (HD) is a debilitating, genetically inherited neurodegenerative disorder that results in early loss of medium spiny neurons from the…”
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Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities by Tabrizi, Sarah J, Estevez-Fraga, Carlos, van Roon-Mom, Willeke M C, Flower, Michael D, Scahill, Rachael I, Wild, Edward J, Muñoz-Sanjuan, Ignacio, Sampaio, Cristina, Rosser, Anne E, Leavitt, Blair R

“…Huntington's disease is the most frequent autosomal dominant neurodegenerative disorder; however, no disease-modifying interventions are available for patients…”
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Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression by Scherf, Caroline, Kelly, Claire M, Allen, Nicholas D, Battersby, Alysia, Penketh, Richard, Precious, Sophie V, Rosser, Anne E, Amso, Nazar N, Dunnett, Stephen B

“…Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability…”
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