Search Results - "Rossano, Lucius"

A Mechanistic Study on the Amidation of Esters Mediated by Sodium Formamide by Ramirez, Antonio, Mudryk, Boguslaw, Rossano, Lucius, Tummala, Srinivas

“…Kinetic and computational studies on the amidation of esters with mixtures of formamide and sodium methoxide are described. Rate studies are consistent with a…”
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Preparation of β‑hydroxy-α-amino Acid Using Recombinant d‑Threonine Aldolase by Goldberg, Steven L, Goswami, Animesh, Guo, Zhiwei, Chan, Yeung, Lo, Ehrlic T, Lee, Andrew, Truc, Vu Chi, Natalie, Kenneth J, Hang, Chao, Rossano, Lucius T, Schmidt, Michael A

“…The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API…”
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Development of a Two-Step, Enantioselective Synthesis of an Amino Alcohol Drug Candidate by Schmidt, Michael A, Reiff, Emily A, Qian, Xinhua, Hang, Chao, Truc, Vu Chi, Natalie, Kenneth J, Wang, Chenchi, Albrecht, Jacob, Lee, Andrew G, Lo, Ehrlic T, Guo, Zhiwei, Goswami, Animesh, Goldberg, Steven, Pesti, Jaan, Rossano, Lucius T

“…The process development and large scale synthesis for the β-hydroxyamino amide 1 is described. The route evolved from a multistep sequence utilizing a…”
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Efficient Synthesis of Losartan, A Nonpeptide Angiotensin II Receptor Antagonist by Larsen, Robert D, King, Anthony O, Chen, Cheng Y, Corley, Edward G, Foster, Bruce S, Roberts, F. Edward, Yang, Chunhua, Lieberman, David R, Reamer, Robert A, Tschaen, David M, Verhoeven, Thomas R, Reider, Paul J, Lo, Young S, Rossano, Lucius T, Brookes, A. Sidney, Meloni, David, Moore, James R, Arnett, John F

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Model-Guided Design Space Development for a Drug Substance Manufacturing Process by L. Burt, Justin, D. Braem, Alan, Ramirez, Antonio, Mudryk, Boguslaw, Rossano, Lucius, Tummala, Srinivas

“…This case study outlines an application of quality by design principles to a drug substance manufacturing process. A hybrid process chemistry model consisting…”
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Stereocontrolled synthesis of highly oxygenated acyclic systems via the enolate Claisen rearrangement of O-protected allylic glycolates by Gould, Thomas J, Balestra, Michael, Wittman, Mark D, Gary, Jill A, Rossano, Lucius T, Kallmerten, James

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Synthetic studies of the nargenicins. Introduction of the C14-C19 side chain by diastereoselective [2,3] Wittig rearrangement of a tertiary allylic ether by Rossano, Lucius T, Plata, Daniel J, Kallmerten, James

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An Example of Utilizing Mechanistic and Empirical Modeling in Quality by Design by Hallow, Daniel M., Mudryk, Boguslaw M., Braem, Alan D., Tabora, Jose E., Lyngberg, Olav K., Bergum, James S., Rossano, Lucius T., Tummala, Srinivas

“…In this case study, we present an approach for employing modeling to help define the design space for a reaction with potential to generate an impurity that…”
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A Practical Synthesis of Nonpeptide Cyclic Ureas as Potent HIV Protease Inhibitors by Rossano, L

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A practical synthesis of nonpeptide cyclic ureas as potent HIV protease inhibitors by Rossano, Lucius T., Lo, Young S., Anzalone, Luigi, Lee, Ying-Chi, Meloni, David J., Moore, James R., Gale, Timothy M., Arnett, John F.

“…The utilization of the oxydimethylene group to form a trioxepane ring for the protection of 1,2-diols was demonstrated. A process starting with natural…”
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Preparation of n-butyl-2-(2′-triphenylmethyltetrazol-5-yl)phenylborinic acid by Lo, Young S., Rossano, Lucius T., Meloni, David J., Moore, James R., Lee, Ying-Chi, Arnett, John F.

“…Understanding the mechanism of formation of an impurity in the key step of the synthesis of Losartan (1) helped devise a procedure to synthesize the title…”
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