Search Results - "Rossaert, Elisabeth"

Histone Deacetylase Inhibition Regulates Lipid Homeostasis in a Mouse Model of Amyotrophic Lateral Sclerosis by Burg, Thibaut, Rossaert, Elisabeth, Moisse, Matthieu, Van Damme, Philip, Van Den Bosch, Ludo

“…Amyotrophic lateral sclerosis (ALS) is an incurable and fatal neurodegenerative disorder of the motor system. While the etiology is still incompletely…”
Get full text

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth by Van Helleputte, Lawrence, Kater, Mandy, Cook, Dana P., Eykens, Caroline, Rossaert, Elisabeth, Haeck, Wanda, Jaspers, Tom, Geens, Natasja, Vanden Berghe, Pieter, Gysemans, Conny, Mathieu, Chantal, Robberecht, Wim, Van Damme, Philip, Cavaletti, Guido, Jarpe, Matthew, Van Den Bosch, Ludo

“…As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs…”
Get full text

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model by Rossaert, Elisabeth, Pollari, Eveliina, Jaspers, Tom, Van Helleputte, Lawrence, Jarpe, Matthew, Van Damme, Philip, De Bock, Katrien, Moisse, Matthieu, Van Den Bosch, Ludo

“…Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many…”
Get full text

AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS by Eykens, Caroline, Rossaert, Elisabeth, Duqué, Sandra, Rué, Laura, Bento-Abreu, André, Hersmus, Nicole, Lenaerts, Annette, Kerstens, Axelle, Corthout, Nikky, Munck, Sebastian, Van Damme, Philip, Holt, Matthew G., von Jonquires, Georg, Klugmann, Matthias, Van Den Bosch, Ludo, Robberecht, Wim

“…Oligodendrocyte dysfunction has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder characterized by…”
Get full text

HDAC6 inhibitors: Translating genetic and molecular insights into a therapy for axonal CMT by Rossaert, Elisabeth, Van Den Bosch, Ludo

“…•Axonal transport defects are a common hallmark in models of axonal CMT.•HDAC6 plays a central role in several pathomechanisms of axonal CMT.•HDAC6 inhibitors…”
Get full text

Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition by Stoklund Dittlau, Katarina, Krasnow, Emily N., Fumagalli, Laura, Vandoorne, Tijs, Baatsen, Pieter, Kerstens, Axelle, Giacomazzi, Giorgia, Pavie, Benjamin, Rossaert, Elisabeth, Beckers, Jimmy, Sampaolesi, Maurilio, Van Damme, Philip, Van Den Bosch, Ludo

“…Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and muscle; however, in MN disorders, such as amyotrophic lateral sclerosis…”
Get full text

HDAC3 Inhibition Stimulates Myelination in a CMT1A Mouse Model by Prior, Robert, Verschoren, Stijn, Vints, Katlijn, Jaspers, Tom, Rossaert, Elisabeth, Klingl, Yvonne E., Silva, Alessio, Hersmus, Nicole, Van Damme, Philip, Van Den Bosch, Ludo

“…Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral neuropathy, with currently no effective treatment or cure. CMT1A is caused by a…”
Get full text

PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells by Prior, Robert, Silva, Alessio, Vangansewinkel, Tim, Idkowiak, Jakub, Tharkeshwar, Arun Kumar, Hellings, Tom P, Michailidou, Iliana, Vreijling, Jeroen, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Agaser, Cedrick, Kuipers, Thomas B, Michiels, Christine, Rossaert, Elisabeth, Verschoren, Stijn, Vermeire, Wendy, de Laat, Vincent, Dehairs, Jonas, Eggermont, Kristel, van den Biggelaar, Diede, Bademosi, Adekunle T, Meunier, Frederic A, vandeVen, Martin, Van Damme, Philip, Mei, Hailiang, Swinnen, Johannes V, Lambrichts, Ivo, Baas, Frank, Fluiter, Kees, Wolfs, Esther, Van Den Bosch, Ludo

“…Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy caused by a 1.5 Mb tandem duplication of chromosome 17…”
Get full text