Search Results - "Ross, Ted M."

Dengue virus and the host innate immune response by Uno, Naoko, Ross, Ted M.

“…Dengue virus (DENV) is a mosquito-borne Flavivirus that is endemic in many tropical and sub-tropical countries where the transmission vectors Aedes spp…”
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Multivalent next generation influenza virus vaccines protect against seasonal and pre-pandemic viruses by Uno, Naoko, Ross, Ted M.

“…Each year, new influenza virus vaccine formulations are generated to keep up with continuously circulating and mutating viral variants. A next-generation…”
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Towards a universal influenza vaccine: different approaches for one goal by Sautto, Giuseppe A, Kirchenbaum, Greg A, Ross, Ted M

“…Influenza virus infection is an ongoing health and economic burden causing epidemics with pandemic potential, affecting 5-30% of the global population…”
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Hemagglutination Inhibition (HAI) antibody landscapes after vaccination with H7Nx virus like particles by Jang, Hyesun, Ross, Ted M

“…A systemic evaluation of the antigenic differences of the H7 influenza hemagglutinin (HA) proteins, especially for the viruses isolated after 2016, are…”
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Next generation methodology for updating HA vaccines against emerging human seasonal influenza A(H3N2) viruses by Allen, James D., Ross, Ted M.

“…While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal…”
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Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection by Winkler, Emma S., Gilchuk, Pavlo, Yu, Jinsheng, Bailey, Adam L., Chen, Rita E., Chong, Zhenlu, Zost, Seth J., Jang, Hyesun, Huang, Ying, Allen, James D., Case, James Brett, Sutton, Rachel E., Carnahan, Robert H., Darling, Tamarand L., Boon, Adrianus C.M., Mack, Matthias, Head, Richard D., Ross, Ted M., Crowe, James E., Diamond, Michael S.

“…SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered neutralizing antibodies against SARS-CoV-2 show promise in clinical trials,…”
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H3N2 influenza viruses in humans: Viral mechanisms, evolution, and evaluation by Allen, James D., Ross, Ted M.

“…Annual seasonal influenza vaccines are composed of two influenza A strains representing the H1N1 and H3N2 subtypes, and two influenza B strains representing…”
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Inactivated recombinant influenza vaccine: the promising direction for the next generation of influenza vaccine by Shi, Hua, Ross, Ted M

“…Vaccination is the most effective method to control the prevalence of seasonal influenza and the most widely used influenza vaccine is the inactivated…”
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Anti-neuraminidase immunity in the combat against influenza by Zhang, Xiaojian, Ross, Ted M

“…Anti-neuraminidase (NA) immunity correlates with the protection against influenza virus infection in both human and animal models. The aim of this review is to…”
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A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages by Carlock, Michael A., Ross, Ted M.

“…Influenza B viruses (IBV) can cause severe disease and death much like influenza A viruses (IAV), with a disproportionate number of infections in children…”
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Identification of Hemagglutinin Residues Responsible for H3N2 Antigenic Drift during the 2014–2015 Influenza Season by Chambers, Benjamin S., Parkhouse, Kaela, Ross, Ted M., Alby, Kevin, Hensley, Scott E.

“…Influenza vaccines must be updated regularly because influenza viruses continuously acquire mutations in antibody binding sites of hemagglutinin (HA). The…”
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Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA.1, BA.2 and BA.3 following third mRNA vaccination by Bellusci, Lorenza, Grubbs, Gabrielle, Zahra, Fatema Tuz, Forgacs, David, Golding, Hana, Ross, Ted M., Khurana, Surender

“…There is limited knowledge on durability of neutralization capacity and antibody affinity maturation generated following two versus three doses of SARS-CoV-2…”
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Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines by Jang, Hyesun, Ross, Ted M

“…In this study, we hypothesized that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA…”
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Impaired immune responses in the lungs of aged mice following influenza infection by Toapanta, Franklin R, Ross, Ted M

“…Each year, influenza virus infection causes severe morbidity and mortality, particularly in the most susceptible groups including children, the elderly (>65…”
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mRNA vaccines encoding computationally optimized hemagglutinin elicit protective antibodies against future antigenically drifted H1N1 and H3N2 influenza viruses isolated between 2018-2020 by Allen, James D, Ross, Ted M

“…The implementation of mRNA vaccines against COVID-19 has successfully validated the safety and efficacy of the platform, while at the same time revealing the…”
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Split inactivated COBRA vaccine elicits protective antibodies against H1N1 and H3N2 influenza viruses by Allen, James D, Ray, Satyajit, Ross, Ted M

“…Development of broadly reactive or universal influenza vaccines will be a paradigm shifting event for the influenza vaccine field. These next generation…”
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Evaluation of Pre-Pandemic Trivalent COBRA HA Vaccine in Mice Pre-Immune to Historical H1N1 and H3N2 Influenza Viruses by Ge, Pan, Ross, Ted M

“…Initial exposure to influenza virus(es) during early childhood produces protective antibodies that may be recalled following future exposure to subsequent…”
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Elicitation of Protective Antibodies against 20 Years of Future H3N2 Cocirculating Influenza Virus Variants in Ferrets Preimmune to Historical H3N2 Influenza Viruses by Allen, James D, Jang, Hyesun, DiNapoli, Joshua, Kleanthous, Harold, Ross, Ted M

“…The vast majority of people already have preexisting immune responses to influenza viruses from one or more subtypes. However, almost all preclinical studies…”
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Longitudinal analysis of influenza vaccination implicates regulation of RIG-I signaling by DNA methylation by Fu, Hongxiang, Pickering, Harry, Rubbi, Liudmilla, Ross, Ted M., Reed, Elaine F., Pellegrini, Matteo

“…Influenza virus infection alters the promoter DNA methylation of key immune response-related genes, including type-1 interferons and proinflammatory cytokines…”
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Evaluation of Next-Generation H3 Influenza Vaccines in Ferrets Pre-Immune to Historical H3N2 Viruses by Allen, James D, Ross, Ted M

“…Each person has a unique immune history to past influenza virus infections. Exposure to influenza viruses early in life establishes memory B cell populations…”
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