Search Results - "Ross, Ruth A"

Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses by Sylantyev, Sergiy, Jensen, Thomas P., Ross, Ruth A., Rusakov, Dmitri A.

“…G protein-coupled receptor (GPR) 55 is sensitive to certain cannabinoids, it is expressed in the brain and, in cell cultures, it triggers mobilization of…”
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Anandamide and vanilloid TRPV1 receptors by Ross, Ruth A

“…A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1…”
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putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo by Whyte, Lauren S, Ryberg, Erik, Sims, Natalie A, Ridge, Susan A, Mackie, Ken, Greasley, Peter J, Ross, Ruth A, Rogers, Michael J

“…GPR55 is a G protein-coupled receptor recently shown to be activated by certain cannabinoids and by lysophosphatidylinositol (LPI). However, the physiological…”
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The Trifluoromethyl Group as a Bioisosteric Replacement of the Aliphatic Nitro Group in CB1 Receptor Positive Allosteric Modulators by Tseng, Chih-Chung, Baillie, Gemma, Donvito, Giulia, Mustafa, Mohammed A, Juola, Sophie E, Zanato, Chiara, Massarenti, Chiara, Dall’Angelo, Sergio, Harrison, William T. A, Lichtman, Aron H, Ross, Ruth A, Zanda, Matteo, Greig, Iain R

“…The first generation of CB1 positive allosteric modulators (e.g., ZCZ011) featured a 3-nitroalkyl-2-phenyl-indole structure. Although a small number of drugs…”
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Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease by Mounsey, Ross B., Mustafa, Sarah, Robinson, Lianne, Ross, Ruth A., Riedel, Gernot, Pertwee, Roger G., Teismann, Peter

“…Parkinson's disease (PD) is a common chronic neurodegenerative disorder, usually of idiopathic origin. Symptoms including tremor, bradykinesia, rigidity and…”
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Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation by Liangpunsakul, Suthat, Toh, Evelyn, Ross, Ruth A., Heathers, Laura E., Chandler, Kristina, Oshodi, AdePeju, McGee, Breann, Modlik, Elizabeth, Linton, Tobyn, Mangiacarne, Darrin, Jimenez, Claudie, Dong, X. Charlie, Wang, Li, Tu, Wanzhu, Nelson, David E.

“…It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of…”
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Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines by Brown, Iain, Cascio, Maria G., Wahle, Klaus W.J., Smoum, Reem, Mechoulam, Raphael, Ross, Ruth A., Pertwee, Roger G., Heys, Steven D.

“…The omega-3 fatty acid ethanolamides, docosahexaenoyl ethanolamide (DHEA) and eicosapentaenoyl ethanolamide (EPEA), displayed greater anti-proliferative…”
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Hardwiring the Brain: Endocannabinoids Shape Neuronal Connectivity by Berghuis, Paul, Rajnicek, Ann M, Morozov, Yury M, Ross, Ruth A, Mulder, Jan, Urbán, Gabriella M, Monory, Krisztina, Marsicano, Giovanni, Matteoli, Michela, Canty, Alison, Irving, Andrew J, Katona, István, Yanagawa, Yuchio, Rakic, Pasko, Lutz, Beat, Mackie, Ken, Harkany, Tibor

“…The roles of endocannabinoid signaling during central nervous system development are unknown. We report that CB₁ cannabinoid receptors (CB₁Rs) are enriched in…”
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Genetic background can result in a marked or minimal effect of gene knockout (GPR55 and CB2 receptor) in experimental autoimmune encephalomyelitis models of multiple sclerosis by Sisay, Sofia, Pryce, Gareth, Jackson, Samuel J, Tanner, Carolyn, Ross, Ruth A, Michael, Gregory J, Selwood, David L, Giovannoni, Gavin, Baker, David

“…Endocannabinoids and some phytocannabinoids bind to CB1 and CB2 cannabinoid receptors, transient receptor potential vanilloid one (TRPV1) receptor and the…”
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Imipramine blocks ethanol-induced ASMase activation, ceramide generation, and PP2A activation, and ameliorates hepatic steatosis in ethanol-fed mice by Liangpunsakul, Suthat, Rahmini, Yasmeen, Ross, Ruth A, Zhao, Zhenwen, Xu, Yan, Crabb, David W

“…Our previous data showed the inhibitory effect of ethanol on AMP-activated protein kinase phosphorylation, which appears to be mediated, in part, through…”
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Disturbances in the murine hepatic circadian clock in alcohol-induced hepatic steatosis by Zhou, Peng, Ross, Ruth A., Pywell, Cameron M., Liangpunsakul, Suthat, Duffield, Giles E.

“…To investigate the role of the circadian clock in the development of alcohol-induced fatty liver disease we examined livers of mice chronically alcohol-fed…”
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A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans by Romero-Zerbo, Silvana Y, Rafacho, Alex, Díaz-Arteaga, Adenis, Suárez, Juan, Quesada, Ivan, Imbernon, Mónica, Ross, Ruth A, Dieguez, Carlos, Rodríguez de Fonseca, Fernando, Nogueiras, Rubén, Nadal, Ángel, Bermúdez-Silva, Francisco J

“…The cannabinoid CB1 receptor is a well-known player in energy homeostasis and its specific antagonism has been used in clinical practice for the treatment of…”
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Allosteric modulation of the cannabinoid CB1 receptor by Price, Martin R, Baillie, Gemma L, Thomas, Adèle, Stevenson, Lesley A, Easson, Morag, Goodwin, Richard, McLean, Adèle, McIntosh, Lorraine, Goodwin, Gillian, Walker, Glenn, Westwood, Paul, Marrs, Julia, Thomson, Fiona, Cowley, Phillip, Christopoulos, Arthur, Pertwee, Roger G, Ross, Ruth A

“…We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide),…”
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Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity by Cai, Yan, Xu, Ming-Jiang, Koritzinsky, Erik H, Zhou, Zhou, Wang, Wei, Cao, Haixia, Yuen, Peter St, Ross, Ruth A, Star, Robert A, Liangpunsakul, Suthat, Gao, Bin

“…Over the last several years, one of the major advances in the field of alcoholic liver disease research was the discovery that binge alcohol consumption…”
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Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors by Ralston, Stuart H, Idris, Aymen I, van 't Hof, Robert J, Greig, Iain R, Ridge, Susan A, Baker, David, Ross, Ruth A

“…Accelerated osteoclastic bone resorption has a central role in the pathogenesis of osteoporosis and other bone diseases. Identifying the molecular pathways…”
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Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2 by McHugh, Douglas, Tanner, Carolyn, Mechoulam, Raphael, Pertwee, Roger G, Ross, Ruth A

“…Here, we show a novel pharmacology for inhibition of human neutrophil migration by endocannabinoids, phytocannabinoids, and related compounds. The…”
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The enigmatic pharmacology of GPR55 by Ross, Ruth A

“…Preliminary data presented at conferences and in the patent literature introduced the possibility the orphan receptor GPR55 might account for some of the…”
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Inhibitory effect of ethanol on AMPK phosphorylation is mediated in part through elevated ceramide levels by Liangpunsakul, Suthat, Sozio, Margaret S, Shin, Eric, Zhao, Zhenwen, Xu, Yan, Ross, Ruth A, Zeng, Yan, Crabb, David W

“…Ethanol treatment of cultured hepatoma cells and of mice inhibited the activity of AMP-activated protein kinase (AMPK). This study shows that the inhibitory…”
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Activation of Carbohydrate Response Element–Binding Protein by Ethanol by Liangpunsakul, Suthat, Ross, Ruth A., Crabb, David W.

“…ObjectiveCarbohydrate response element–binding protein (ChREBP) is a transcription factor involved in hepatic lipogenesis. Its function is in part under the…”
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Identification of Novel GPR55 Modulators Using Cell-Impedance-Based Label-Free Technology by Morales, Paula, Whyte, Lauren S, Chicharro, Roberto, Gómez-Cañas, María, Pazos, M. Ruth, Goya, Pilar, Irving, Andrew J, Fernández-Ruiz, Javier, Ross, Ruth A, Jagerovic, Nadine

“…The orphan G protein-coupled receptor GPR55 has been proposed as a novel receptor of the endocannabinoid system. However, the validity of this categorization…”
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