Search Results - "Ross, Nicolette C."

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics by Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein,…”
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Reactive Oxygen and Targeted Antioxidant Administration in Endothelial Cell Mitochondria by O'Malley, Yunxia, Fink, Brian D., Ross, Nicolette C., Prisinzano, Thomas E., Sivitz, William I.

“…We used fluorescent probes and EPR to study the mechanism(s) underlying reactive oxygen species (ROS) production by endothelial cell mitochondria and the…”
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Mitochondrial targeted coenzyme Q, superoxide, and fuel selectivity in endothelial cells by Fink, Brian D, O'Malley, Yunxia, Dake, Brian L, Ross, Nicolette C, Prisinzano, Thomas E, Sivitz, William I

“…Previously, we reported that the "antioxidant" compound "mitoQ" (mitochondrial-targeted ubiquinol/ubiquinone) actually increased superoxide production by…”
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Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias by Kennedy, Nicole M, Schmid, Cullen L, Ross, Nicolette C, Lovell, Kimberly M, Yue, Zhizhou, Chen, Yen Ting, Cameron, Michael D, Bohn, Laura M, Bannister, Thomas D

“…While mu opioid receptor (MOR) agonists are especially effective as broad-spectrum pain relievers, it has been exceptionally difficult to achieve a clear…”
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Physical presence of nor-binaltorphimine in mouse brain over 21 days after a single administration corresponds to its long-lasting antagonistic effect on κ-opioid receptors by Patkar, Kshitij A, Wu, Jinhua, Ganno, Michelle L, Singh, Harminder D, Ross, Nicolette C, Rasakham, Khampaseuth, Toll, Lawrence, McLaughlin, Jay P

“…In the mouse 55°C warm-water tail-withdrawal assay, a single administration of nor-binaltorphimine (nor-BNI; 10 mg/kg i.p.) antagonized κ-opioid receptor (KOR)…”
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Novel opioid cyclic tetrapeptides: Trp isomers of CJ‐15,208 exhibit distinct opioid receptor agonism and short‐acting κ opioid receptor antagonism by Ross, Nicolette C, Reilley, Kate J, Murray, Thomas F, Aldrich, Jane V, McLaughlin, Jay P

“…BACKGROUND AND PURPOSE The κ opioid receptor antagonists demonstrate potential for maintaining abstinence from psychostimulant abuse, but existing non‐peptide…”
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The Macrocyclic Peptide Natural Product CJ-15,208 Is Orally Active and Prevents Reinstatement of Extinguished Cocaine-Seeking Behavior by Aldrich, Jane V, Senadheera, Sanjeewa N, Ross, Nicolette C, Ganno, Michelle L, Eans, Shainnel O, McLaughlin, Jay P

“…The macrocyclic tetrapeptide natural product CJ-15,208 (cyclo[Phe-d-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor (KOR)…”
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Synthesis of CJ-15,208, a novel κ-opioid receptor antagonist by Ross, Nicolette C., Kulkarni, Santosh S., McLaughlin, Jay P., Aldrich, Jane V.

“…A strategy to select linear precursor peptides favoring cyclization was developed and cyclization conditions were optimized. The tryptophan isomers of the…”
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Unexpected Opioid Activity Profiles of Analogues of the Novel Peptide Kappa Opioid Receptor Ligand CJ-15,208 by Aldrich, Jane V., Kulkarni, Santosh S., Senadheera, Sanjeewa N., Ross, Nicolette C., Reilley, Kate J., Eans, Shainnel O., Ganno, Michelle L., Murray, Thomas F., McLaughlin, Jay P.

“…An alanine scan was performed on the novel κ opioid receptor (KOR) peptide ligand CJ‐15,208 to determine which residues contribute to the potent in vivo…”
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Synthesis of cyclic tetrapeptide CJ 15,208: a novel kappa opioid receptor antagonist by Kulkarni, Santosh S, Ross, Nicolette C, McLaughlin, Jay P, Aldrich, Jane V

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Mu Opioid Receptor Agonists with Dopamine D3 Receptor Antagonism: Toward Developing Analgesics with Less Abuse Potential by Shah, Nilay M., Schmid, Cullen L., Merritt, Benjamin, Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Bannister, Thomas D., Bohn, Laura M.

“…Opioid analgesics such as morphine are widely used in clinical practice for the management of moderate to severe pain. While they are the gold standard for…”
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Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting [kappa] opioid receptor antagonism by Ross, Nicolette C, Reilley, Kate J, Murray, Thomas F, Aldrich, Jane V, McLaughlin, Jay P

“…BACKGROUND AND PURPOSE The [kappa] opioid receptor antagonists demonstrate potential for maintaining abstinence from psychostimulant abuse, but existing…”
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The Macrocyclic Peptide Natural Product CJ-15,208 is Orally Active and Prevents Reinstatement of Extinguished Cocaine Seeking Behavior1 by Aldrich, Jane V., Senadheera, Sanjeewa N., Ross, Nicolette C., Ganno, Michelle L., Eans, Shainnel O., McLaughlin, Jay P.

“…The macrocyclic tetrapeptide natural product CJ-15,208 ( cyclo [Phe-D-Pro-Phe-Trp]) exhibited both dose-dependent antinociception and kappa opioid receptor…”
Get full text