Search Results - "Ross, Larry"

Discovery of a novel inhibitor of kinesin-like protein KIFC1 by Zhang, Wei, Zhai, Ling, Wang, Yimin, Boohaker, Rebecca J, Lu, Wenyan, Gupta, Vandana V, Padmalayam, Indira, Bostwick, Robert J, White, E Lucile, Ross, Larry J, Maddry, Joseph, Ananthan, Subramaniam, Augelli-Szafran, Corinne E, Suto, Mark J, Xu, Bo, Li, Rongbao, Li, Yonghe

“…Historically, drugs used in the treatment of cancers also tend to cause damage to healthy cells while affecting cancer cells. Therefore, the identification of…”
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Identification of Small Molecule Inhibitors of Human Cytochrome c Oxidase That Target Chemoresistant Glioma Cells by Oliva, Claudia R., Markert, Tahireh, Ross, Larry J., White, E. Lucile, Rasmussen, Lynn, Zhang, Wei, Everts, Maaike, Moellering, Douglas R., Bailey, Shannon M., Suto, Mark J., Griguer, Corinne E.

“…The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory…”
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Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling by Owusu, Benjamin Y, Bansal, Namita, Venukadasula, Phanindra K M, Ross, Larry J, Messick, Troy E, Goel, Sanjay, Galemmo, Robert A, Klampfer, Lidija

“…The binding of hepatocyte growth factor (HGF) to its receptor MET activates a signaling cascade that promotes cell survival, proliferation, cell scattering,…”
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Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis by Mathew, Bini, Hobrath, Judith Varady, Ross, Larry, Connelly, Michele C, Lofton, Hava, Rajagopalan, Malini, Guy, R Kiplin, Reynolds, Robert C

“…A variety of commercial analogs and a newer series of Sulindac derivatives were screened for inhibition of M. tuberculosis (Mtb) in vitro and specifically as…”
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Unique Functional and Structural Properties of the LRRK2 Protein ATP-binding Pocket by Liu, Zhiyong, Galemmo, Robert A., Fraser, Kyle B., Moehle, Mark S., Sen, Saurabh, Volpicelli-Daley, Laura A., DeLucas, Lawrence J., Ross, Larry J., Valiyaveettil, Jacob, Moukha-Chafiq, Omar, Pathak, Ashish K., Ananthan, Subramaniam, Kezar, Hollis, White, E.Lucile, Gupta, Vandana, Maddry, Joseph A., Suto, Mark J., West, Andrew B.

“…Pathogenic mutations in the LRRK2 gene can cause late-onset Parkinson disease. The most common mutation, G2019S, resides in the kinase domain and enhances…”
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Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors by Mathew, Bini, Srivastava, Shefali, Ross, Larry J., Suling, William J., White, E. Lucile, Woolhiser, Lisa K., Lenaerts, Anne J., Reynolds, Robert C.

“…Eighteen new pyridopyrazine and pyrimidothiazine derivatives were synthesized and tested against FtsZ from Mycobacterium tuberculosis (Mtb) and in vitro…”
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Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK) by Shapiro, Justin A., Varga, John J., Parsonage, Derek, Walton, William, Redinbo, Matthew R., Ross, Larry J., White, E. Lucile, Bostwick, Robert, Wuest, William M., Claiborne, Al, Goldberg, Joanna B.

“…Antibiotics with novel mechanisms of action are desperately needed to combat the increasing rates of multidrug‐resistant infections. Bacterial pantothenate…”
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Severe B Cell Hyperplasia and Autoimmune Disease in TALL-1 Transgenic Mice by Khare, Sanjay D., Sarosi, Ildiko, Xia, Xing-Zhong, McCabe, Susan, Miner, Kent, Solovyev, Irina, Hawkins, Nessa, Kelley, Michael, Chang, David, Van, Gwyneth, Ross, Larry, Delaney, John, Wang, Ling, Lacey, David, Boyle, William J., Hsu, Hailing

“…TALL-1/Blys/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B…”
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Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation by Venukadasula, Phanindra K. M, Owusu, Benjamin Y, Bansal, Namita, Ross, Larry J, Hobrath, Judith V, Bao, Donghui, Truss, Jackie W, Stackhouse, Murray, Messick, Troy E, Klampfer, Lidija, Galemmo, Robert A

“…In this letter we report first nonpeptide inhibitors of hepatocyte growth factor (HGF) activation. These compounds inhibit the three proteases (matriptase,…”
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Building a Culture of Literacy Month-by-Month by Davis, Hilarie

“…This book will help create a culture of literacy at schools, from the classroom, to the lunchroom, to the hallways-a culture that encompasses students,…”
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Structure of Mycobacterium tuberculosis FtsZ Reveals Unexpected, G Protein-like Conformational Switches by Leung, Adelaine K.W., Lucile White, E., Ross, Larry J., Reynolds, Robert C., DeVito, Joseph A., Borhani, David W.

“…We report three crystal structures of the Mycobacterium tuberculosis cell division protein FtsZ, as the citrate, GDP, and GTPγS complexes, determined at 1.89,…”
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Abstract LB-055: High-throughput screening efforts for the identification of selective and potent inhibitors of CD38 for the treatment of hematological cancers by Botta, Davide, Dadali, Tulin, Mousseau, Betty J., Zhou, Fen, Schultz, Michael D., Zumaquero, Esther, Manouvakhova, Anna, Sosa, Melinda I., McKellip, Sara N., Woods, LaKeisha, Tower, Nichole A., Ross, Larry J., Rasmussen, Lynn, White, E. Lucille, Padmalayam, Indira, Zhang, Wei, Everts, Maaike, Augelli-Szafran, Corinne E., Bostwick, James R., Suto, Mark J., Lund, Frances E.

“…By means of a phenomenon termed “the Warburg effect,” tumor cells shift their energy production by mitochondrial oxidative phosphorylation to aerobic…”
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Family, Friends, and Faith: How Organ Donor Families Heal by Stouder, Donald B., Schmid, Adam, Ross, Sharon S., Ross, Larry G., Stocks, Lisa

“…Context Understanding how organ donors' families recover from their grief can help organ procurement organizations improve consent rates and increase the…”
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Family, friends, and faith: how organ donor families heal by Stouder, Donald, Schmid, Adam, Ross, Sharon, Ross, Larry, Stocks, Lisa

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2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ by White, E. Lucile, Suling, William J., Ross, Larry J., Seitz, Lainne E., Reynolds, Robert C.

“…Compounds originally designed as putative tubulin inhibitors were tested as antitubercular agents for inhibition of the Mycobacterium tuberculosis analogue of…”
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Slow Polymerization of Mycobacterium tuberculosis FtsZ by White, E L, Ross, L J, Reynolds, R C, Seitz, L E, Moore, G D, Borhani, D W

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Masquerading as Self? Endoparasitic Strepsiptera (Insecta) Enclose Themselves in Host-Derived Epidermal Bag by Kathirithamby, Jeyaraney, Ross, Larry D., Johnston, J. Spencer

“…We report here the case of a metazoan parasite, a strepsipteran, that manipulates host epidermal tissue and wraps itself within it; which probably camouflages…”
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Atomic Structures of Human Dihydrofolate Reductase Complexed with NADPH and Two Lipophilic Antifolates at 1.09 Å and 1.05 Å Resolution by Klon, Anthony E., Héroux, Annie, Ross, Larry J., Pathak, Vibha, Johnson, Cheryl A., Piper, James R., Borhani, David W.

“…The crystal structures of two human dihydrofolate reductase (hDHFR) ternary complexes, each with bound NADPH cofactor and a lipophilic antifolate inhibitor,…”
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Cloning, expression, and characterization of Mycobacterium tuberculosis dihydrofolate reductase by White, E.Lucile, Ross, Larry J, Cunningham, Amanda, Escuyer, Vincent

“…The gene for dihydrofolate reductase of Mycobacterium tuberculosis was amplified by polymerase chain reaction (PCR) from M. tuberculosis H37Rv strain genomic…”
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Crystal Structure of Toxoplasma gondii Hypoxanthine-Guanine Phosphoribosyltransferase with XMP, Pyrophosphate, and Two Mg2+ Ions Bound:  Insights into the Catalytic Mechanism by Héroux, Annie, White, E. Lucile, Ross, Larry J, Davis, Richard L, Borhani, David W

“…The crystal structure of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase (HGPRT)−xanthosine 5‘-monophosphate (XMP)−pyrophosphate−Mg2+…”
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