Search Results - "Ross, GD"

Mechanism by which orally administered beta-1,3-glucans enhance the tumoricidal activity of antitumor monoclonal antibodies in murine tumor models by Hong, Feng, Yan, Jun, Baran, Jarek T, Allendorf, Daniel J, Hansen, Richard D, Ostroff, Gary R, Xing, Pei Xiang, Cheung, Nai-Kong V, Ross, Gordon D

“…Antitumor mAb bind to tumors and activate complement, coating tumors with iC3b. Intravenously administered yeast beta-1,3;1,6-glucan functions as an adjuvant…”
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Complement function in mAb-mediated cancer immunotherapy by Gelderman, Kyra A., Tomlinson, Stephen, Ross, Gordon D., Gorter, Arko

“…Complement activation by mAbs can cause direct tumor cell lysis or enhance antibody-dependent cell-mediated cytotoxicity. However, tumor cells are protected…”
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β-Glucan functions as an adjuvant for monoclonal antibody immunotherapy by recruiting tumoricidal granulocytes as killer cells by FENG HONG, HANSEN, Richard D, JUN YAN, ALLENDORF, Daniel J, BARAN, Jarek T, OSTROFF, Gary R, ROSS, Gordon D

“…The tumor-killing mechanisms available to monoclonal antibodies (mAbs; e.g., antagonism of growth factor receptors, antibody-dependent cell-mediated…”
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Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow by Ratajczak, Janina, Reca, Ryan, Kucia, Magda, Majka, Marcin, Allendorf, Daniel J., Baran, Jarek T., Janowska-Wieczorek, Anna, Wetsel, Rick A., Ross, Gordon D., Ratajczak, Mariusz Z.

“…The mechanisms regulating the homing/mobilization of hematopoietic stem/progenitor cells (HSPCs) are not fully understood. In our previous studies we showed…”
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The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells by Xia, Y, Vetvicka, V, Yan, J, Hanikýrová, M, Mayadas, T, Ross, G D

“…Mouse leukocyte CR3 (Mac-1, alphaMbeta2 integrin) was shown to function as a receptor for beta-glucans in the same way as human CR3. Soluble zymosan…”
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Soluble beta-glucan polysaccharide binding to the lectin site of neutrophil or natural killer cell complement receptor type 3 (CD11b/CD18) generates a primed state of the receptor capable of mediating cytotoxicity of iC3b-opsonized target cells by Vetvicka, V, Thornton, B P, Ross, G D

“…When phagocyte CR3 binds to iC3b on bacteria or yeast, phagocytosis and degranulation are triggered because of simultaneous recognition of iC3b via a CD11b…”
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Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18) by Xia, Y, Ross, G D

“…CR3 (Mac-1; alphaMbeta2 integrin) functions as both a receptor for the opsonic iC3b fragment of C3 triggering phagocytosis or cytotoxicity and an adhesion…”
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Analysis of the sugar specificity and molecular location of the beta- glucan-binding lectin site of complement receptor type 3 (CD11b/CD18) by Thornton, BP, Vetvicka, V, Pitman, M, Goldman, RC, Ross, GD

“…Zymosan, the cell wall from Saccharomyces cerevisiae, was reported to be a macrophage activator through its beta-glucan over 30 yr ago. Nevertheless, the…”
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Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells by RATAJCZAK, M. Z, RECA, R, WYSOCZYNSKI, M, KUCIA, M, BARAN, J. T, ALLENDORF, D. J, RATAJCZAK, J, ROSS, G. D

“…Mice deficient in complement C3 (C3(-/-)) are hematologically normal under steady-state conditions, and yet displayed a significant delay in hematopoietic…”
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Role of the lectin domain of Mac-1/CR3 (CD11b/CD18) in regulating intercellular adhesion by Ross, Gordon D

“…Leukocyte diapedesis requires that Mac-1/CR3-dependent adhesion be regulated so that cells can move from one attachment site to another. The high affinity…”
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Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18) by Yan, J, Vetvicka, V, Xia, Y, Coxon, A, Carroll, M C, Mayadas, T N, Ross, G D

“…beta-Glucans were identified 36 years ago as a biologic response modifier that stimulated tumor rejection. In vitro studies have shown that beta-glucans bind…”
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Function of the Lectin Domain of Mac-1/Complement Receptor Type 3 (CD11b/CD18) in Regulating Neutrophil Adhesion by Xia, Yu, Borland, Gita, Huang, Jibiao, Mizukami, Ikuko F, Petty, Howard R, Todd, Robert F., III, Ross, Gordon D

“…A lectin function within CD11b mediates both cytotoxic priming of Mac-1/complement receptor type 3 (CR3) by beta-glucan and the formation of transmembrane…”
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CR3 (CD11b, CD18): a phagocyte and NK cell membrane receptor with multiple ligand specificities and functions by ROSS, G. D., VĚTVIČKA, V.

“…SUMMARY The C3 receptor CR3 is expressed on phagocytie cells, minor subsets of B and T eells. and natural killer (NK) cells. It has important functions both as…”
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Therapeutic intervention with complement and β-glucan in cancer by Ross, Gordon D, Větvička, Václav, Yan, Jun, Xia, Yu, Větvičková, Jana

“…Complement (C) has two major effector systems available for host defense. The membrane attack complex (MAC) generated from components C5–C9 can form…”
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Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes by Thornton, BP, Vetvicka, V, Ross, GD

“…Normal immune responses to primary protein Ags (those not seen previously by the immune system) have been shown to require C3 and the C3 receptor CR2 (CD21)…”
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Subchronic exposure of [3H]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: Relationship of steady-state levels to disposition and metabolism by DILIBERTO, Janet J, DEVITO, Michael J, ROSS, David G, BIRNBAUM, Linda S

“…The present study of subchronic low exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at or near steady-state levels tries to emulate the most probable…”
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Targeting of natural killer cells to mammary carcinoma via naturally occurring tumor cell-bound iC3b and beta-glucan-primed CR3 (CD11b/CD18) by Vetvicka, V, Thornton, BP, Wieman, TJ, Ross, GD

“…Previous reports have suggested that malignant cells frequently generate a humoral immune response that is ineffective in tumor destruction. Despite coating…”
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Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle by Pemberton, M, Anderson, G, Vetvicka, V, Justus, DE, Ross, GD

“…Reperfusion of ischemic tissue is associated with tissue injury greater than that resulting from ischemia alone. C activation has been hypothesized to mediate…”
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Function of C3 in a humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and a primary antigen promotes antigen uptake and the expression of co‐stimulatory molecules by all B cells, but only stimulates immunoglobulin synthesis by antigen‐specific B cells by THORNTON, B. P., VĚTVIČKA, V., ROSS, G. D.

“…Previous studies have shown that an optimal humoral response to a primary protein antigen requires C3 and CR2 (CD21). Sera from non‐immunized donors contain…”
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Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3 by MYONES, B. L, DALZELL, J. G, HOGG, N, ROSS, G. D

“…Previous investigations of p150,95 (CD11c), the third member of the CD18 membrane glycoprotein family that includes CR3 (Mac-1 or CD11b) and LFA-1 (CD11a), had…”
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