Search Results - "Ross, Elizabeth M."

Unlocking the genetic complexity of congenital hydrocephalus by Ross, M. Elizabeth

“…Genome sequencing of patients with sporadic congenital hydrocephalus reveals mutations of large effect size indicative of a developmental origin for the…”
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A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain by Joglekar, Anoushka, Prjibelski, Andrey, Mahfouz, Ahmed, Collier, Paul, Lin, Susan, Schlusche, Anna Katharina, Marrocco, Jordan, Williams, Stephen R., Haase, Bettina, Hayes, Ashley, Chew, Jennifer G., Weisenfeld, Neil I., Wong, Man Ying, Stein, Alexander N., Hardwick, Simon A., Hunt, Toby, Wang, Qi, Dieterich, Christoph, Bent, Zachary, Fedrigo, Olivier, Sloan, Steven A., Risso, Davide, Jarvis, Erich D., Flicek, Paul, Luo, Wenjie, Pitt, Geoffrey S., Frankish, Adam, Smit, August B., Ross, M. Elizabeth, Tilgner, Hagen U.

“…Splicing varies across brain regions, but the single-cell resolution of regional variation is unclear. We present a single-cell investigation of differential…”
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Single-cell isoform RNA sequencing characterizes isoforms in thousands of cerebellar cells by Gupta, Ishaan, Collier, Paul G, Haase, Bettina, Mahfouz, Ahmed, Joglekar, Anoushka, Floyd, Taylor, Koopmans, Frank, Barres, Ben, Smit, August B, Sloan, Steven A, Luo, Wenjie, Fedrigo, Olivier, Ross, M Elizabeth, Tilgner, Hagen U

“…Full-length spliced RNA isoforms are identified in thousands of single cerebellar cells. Full-length RNA sequencing (RNA-Seq) has been applied to bulk tissue,…”
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Activation of RhoC by regulatory ubiquitination is mediated by LNX1 and suppressed by LIS1 by Kholmanskikh, Stanislav, Singh, Shawn, Ross, M. Elizabeth

“…Regulation of Rho GTPases remains a topic of active investigation as they are essential participants in cell biology and the pathophysiology of many human…”
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Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex by Bendriem, Raphael M, Singh, Shawn, Aleem, Alice Abdel, Antonetti, David A, Ross, M Elizabeth

“…( ) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN…”
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Metagenomic Predictions: A Review 10 years on by Ross, Elizabeth M, Hayes, Ben J

“…Metagenomic predictions use variation in the metagenome (microbiome profile) to predict the unknown phenotype of the associated host. Metagenomic predictions…”
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Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling by Allen, Megan, Huang, Ben S., Notaras, Michael J., Lodhi, Aiman, Barrio-Alonso, Estibaliz, Lituma, Pablo J., Wolujewicz, Paul, Witztum, Jonathan, Longo, Francesco, Chen, Maoshan, Greening, David W., Klann, Eric, Ross, M. Elizabeth, Liston, Conor, Colak, Dilek

“…The cellular mechanisms of autism spectrum disorder (ASD) are poorly understood. Cumulative evidence suggests that abnormal synapse function underlies many…”
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Postzygotic inactivating mutations of RHOA cause a mosaic neuroectodermal syndrome by Vabres, Pierre, Sorlin, Arthur, Kholmanskikh, Stanislav S., Demeer, Bénédicte, St-Onge, Judith, Duffourd, Yannis, Kuentz, Paul, Courcet, Jean-Benoît, Carmignac, Virginie, Garret, Philippine, Bessis, Didier, Boute, Odile, Bron, Alain, Captier, Guillaume, Carmi, Esther, Devauchelle, Bernard, Geneviève, David, Gondry-Jouet, Catherine, Guibaud, Laurent, Lafon, Arnaud, Mathieu-Dramard, Michèle, Thevenon, Julien, Dobyns, William B., Bernard, Geneviève, Polubothu, Satyamaanasa, Faravelli, Francesca, Kinsler, Veronica A., Thauvin, Christel, Faivre, Laurence, Ross, M. Elizabeth, Rivière, Jean-Baptiste

“…Hypopigmentation along Blaschko’s lines is a hallmark of a poorly defined group of mosaic syndromes whose genetic causes are unknown. Here we show that…”
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Multi-breed genomic evaluation for tropical beef cattle when no pedigree information is available by Hayes, Ben J, Copley, James, Dodd, Elsie, Ross, Elizabeth M, Speight, Shannon, Fordyce, Geoffry

“…Abstract Background It has been challenging to implement genomic selection in multi-breed tropical beef cattle populations. If commercial (often crossbred)…”
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Mutation in noncoding RNA RNU12 causes early onset cerebellar ataxia by Elsaid, Mahmoud Fawzi, Chalhoub, Nader, Ben‐Omran, Tawfeg, Kumar, Pankaj, Kamel, Hussein, Ibrahim, Khalid, Mohamoud, Yasmin, Al‐Dous, Eman, Al‐Azwani, Iman, Malek, Joel A., Suhre, Karsten, Ross, M. Elizabeth, Aleem, Alice Abdel

“…Objective Exome sequences account for only 2% of the genome and may overlook mutations causing disease. To obtain a more complete view, whole genome sequencing…”
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Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate by Petros, Timothy J., Bultje, Ronald S., Ross, M. Elizabeth, Fishell, Gord, Anderson, Stewart A.

“…Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area…”
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The Ciliary Margin Zone of the Mammalian Retina Generates Retinal Ganglion Cells by Marcucci, Florencia, Murcia-Belmonte, Veronica, Wang, Qing, Coca, Yaiza, Ferreiro-Galve, Susana, Kuwajima, Takaaki, Khalid, Sania, Ross, M. Elizabeth, Mason, Carol, Herrera, Eloisa

“…The retina of lower vertebrates grows continuously by integrating new neurons generated from progenitors in the ciliary margin zone (CMZ). Whether the…”
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Genomic prediction using low-coverage portable Nanopore sequencing by Lamb, Harrison J, Hayes, Ben J, Randhawa, Imtiaz A S, Nguyen, Loan T, Ross, Elizabeth M

“…Most traits in livestock, crops and humans are polygenic, that is, a large number of loci contribute to genetic variation. Effects at these loci lie along a…”
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Expression network analysis of bovine skin infested with Rhipicephalus australis identifies pro-inflammatory genes contributing to tick susceptibility by Mantilla Valdivieso, Emily F., Ross, Elizabeth M., Raza, Ali, Nguyen, Loan, Hayes, Ben J., Jonsson, Nicholas N., James, Peter, Tabor, Ala E.

“…The skin is the primary feeding site of ticks that infest livestock animals such as cattle. The highly specialised functions of skin at the molecular level may…”
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Metagenomic predictions: from microbiome to complex health and environmental phenotypes in humans and cattle by Ross, Elizabeth M, Moate, Peter J, Marett, Leah C, Cocks, Ben G, Hayes, Ben J

“…Mammals have a large cohort of endo- and ecto- symbiotic microorganisms (the microbiome) that potentially influence host phenotypes. There have been numerous…”
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Chromosome-Scale Genome Assembly of the Sheep-Biting Louse Bovicola ovis Using Nanopore Sequencing Data and Pore-C Analysis by Ong, Chian Teng, Mody, Karishma T, Cavallaro, Antonino S, Yan, Yakun, Nguyen, Loan T, Shao, Renfu, Mitter, Neena, Mahony, Timothy J, Ross, Elizabeth M

“…, commonly known as the sheep-biting louse, is an ectoparasite that adversely affects the sheep industry. Sheep louse infestation lowers the quality of…”
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Systems biology analysis of human genomes points to key pathways conferring spina bifida risk by Aguiar-Pulido, Vanessa, Wolujewicz, Paul, Martinez-Fundichely, Alexander, Elhaik, Eran, Thareja, Gaurav, Aleem, Alice Abdel, Chalhoub, Nader, Cuykendall, Tawny, Al-Zamer, Jamel, Lei, Yunping, El-Bashir, Haitham, Musser, James M., Al-Kaabi, Abdulla, Shaw, Gary M., Khurana, Ekta, Suhre, Karsten, Mason, Christopher E., Elemento, Olivier, Finnell, Richard H., Ross, M. Elizabeth

“…Spina bifida (SB) is a debilitating birth defect caused by multiple gene and environment interactions. Though SB shows non-Mendelian inheritance, genetic…”
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A linkage disequilibrium-based approach to position unmapped SNPs in crop species by Yadav, Seema, Ross, Elizabeth M, Aitken, Karen S, Hickey, Lee T, Powell, Owen, Wei, Xianming, Voss-Fels, Kai P, Hayes, Ben J

“…Abstract Background High-density SNP arrays are now available for a wide range of crop species. Despite the development of many tools for generating genetic…”
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Adaptive sampling during sequencing reveals the origins of the bovine reproductive tract microbiome across reproductive stages and sexes by Ong, Chian Teng, Ross, Elizabeth M., Boe-Hansen, Gry, Turni, Conny, Hayes, Ben J., Fordyce, Geoffry, Tabor, Ala E.

“…Cattle enterprises are one of the major livestock production systems globally and are forecasted to have stable growth in the next decade. To facilitate…”
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Schizophrenia endothelial cells exhibit higher permeability and altered angiogenesis patterns in patient-derived organoids by Stankovic, Isidora, Notaras, Michael, Wolujewicz, Paul, Lu, Tyler, Lis, Raphael, Ross, M. Elizabeth, Colak, Dilek

“…Schizophrenia (SCZ) is a complex neurodevelopmental disorder characterized by the manifestation of psychiatric symptoms in early adulthood. While many research…”
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