Search Results - "Ross, Debbie S."

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex by Howell, Jessica J., Hellberg, Kristina, Turner, Marc, Talbott, George, Kolar, Matthew J., Ross, Debbie S., Hoxhaj, Gerta, Saghatelian, Alan, Shaw, Reuben J., Manning, Brendan D.

“…Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. However, knowledge of the full effects of metformin on biochemical pathways…”
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Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD by Garcia, Daniel, Hellberg, Kristina, Chaix, Amandine, Wallace, Martina, Herzig, Sébastien, Badur, Mehmet G., Lin, Terry, Shokhirev, Maxim N., Pinto, Antonio F.M., Ross, Debbie S., Saghatelian, Alan, Panda, Satchidananda, Dow, Lukas E., Metallo, Christian M., Shaw, Reuben J.

“…The AMP-activated protein kinase (AMPK) is a highly conserved master regulator of metabolism, whose activation has been proposed to be therapeutically…”
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The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC by Hollstein, Pablo E, Eichner, Lillian J, Brun, Sonja N, Kamireddy, Anwesh, Svensson, Robert U, Vera, Liliana I, Ross, Debbie S, Rymoff, T J, Hutchins, Amanda, Galvez, Hector M, Williams, April E, Shokhirev, Maxim N, Screaton, Robert A, Berdeaux, Rebecca, Shaw, Reuben J

“…Mutations in the LKB1 (also known as ) tumor suppressor are the third most frequent genetic alteration in non-small cell lung cancer (NSCLC). encodes a…”
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Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks by Stein, Benjamin D., Calzolari, Diego, Hellberg, Kristina, Hu, Ying S., He, Lin, Hung, Chien-Min, Toyama, Erin Q., Ross, Debbie S., Lillemeier, Björn F., Cantley, Lewis C., Yates, John R., Shaw, Reuben J.

“…Metformin is the front-line treatment for type 2 diabetes worldwide. It acts via effects on glucose and lipid metabolism in metabolic tissues, leading to…”
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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models by Eichner, Lillian J., Brun, Sonja N., Herzig, Sébastien, Young, Nathan P., Curtis, Stephanie D., Shackelford, David B., Shokhirev, Maxim N., Leblanc, Mathias, Vera, Liliana I., Hutchins, Amanda, Ross, Debbie S., Shaw, Reuben J., Svensson, Robert U.

“…AMPK, a conserved sensor of low cellular energy, can either repress or promote tumor growth depending on the context. However, no studies have examined AMPK…”
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HDAC3 is critical in tumor development and therapeutic resistance in Kras -mutant non-small cell lung cancer by Eichner, Lillian J, Curtis, Stephanie D, Brun, Sonja N, McGuire, Caroline K, Gushterova, Irena, Baumgart, Joshua T, Trefts, Elijah, Ross, Debbie S, Rymoff, Tammy J, Shaw, Reuben J

“…HDAC3 is one of the main targets of histone deacetylase (HDAC) inhibitors in clinical development as cancer therapies, yet the in vivo role of HDAC3 in solid…”
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