Search Results - "Ross, Christopher A."

Huntington's disease: from molecular pathogenesis to clinical treatment by Ross, Christopher A, Dr, Tabrizi, Sarah J, FRCP

“…Summary Huntington's disease is a progressive, fatal, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene, which encodes an…”
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Transcriptome-wide discovery of microRNA binding sites in human brain by Boudreau, Ryan L, Jiang, Peng, Gilmore, Brian L, Spengler, Ryan M, Tirabassi, Rebecca, Nelson, Jay A, Ross, Christopher A, Xing, Yi, Davidson, Beverly L

“…The orchestration of brain function requires complex gene regulatory networks that are modulated, in part, by microRNAs (miRNAs). These noncoding RNAs…”
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Mutant Huntingtin Disrupts the Nuclear Pore Complex by Grima, Jonathan C., Daigle, J. Gavin, Arbez, Nicolas, Cunningham, Kathleen C., Zhang, Ke, Ochaba, Joseph, Geater, Charlene, Morozko, Eva, Stocksdale, Jennifer, Glatzer, Jenna C., Pham, Jacqueline T., Ahmed, Ishrat, Peng, Qi, Wadhwa, Harsh, Pletnikova, Olga, Troncoso, Juan C., Duan, Wenzhen, Snyder, Solomon H., Ranum, Laura P.W., Thompson, Leslie M., Lloyd, Thomas E., Ross, Christopher A., Rothstein, Jeffrey D.

“…Huntington’s disease (HD) is caused by an expanded CAG repeat in the Huntingtin (HTT) gene. The mechanism(s) by which mutant HTT (mHTT) causes disease is…”
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RAN Translation in Huntington Disease by Bañez-Coronel, Monica, Ayhan, Fatma, Tarabochia, Alex D, Zu, Tao, Perez, Barbara A, Tusi, Solaleh Khoramian, Pletnikova, Olga, Borchelt, David R, Ross, Christopher A, Margolis, Russell L, Yachnis, Anthony T, Troncoso, Juan C, Ranum, Laura P W

“…Huntington disease (HD) is caused by a CAG ⋅ CTG expansion in the huntingtin (HTT) gene. While most research has focused on the HTT polyGln-expansion protein,…”
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Synaptic dysregulation in a human iPS cell model of mental disorders by Wen, Zhexing, Nguyen, Ha Nam, Guo, Ziyuan, Lalli, Matthew A., Wang, Xinyuan, Su, Yijing, Kim, Nam-Shik, Yoon, Ki-Jun, Shin, Jaehoon, Zhang, Ce, Makri, Georgia, Nauen, David, Yu, Huimei, Guzman, Elmer, Chiang, Cheng-Hsuan, Yoritomo, Nadine, Kaibuchi, Kozo, Zou, Jizhong, Christian, Kimberly M., Cheng, Linzhao, Ross, Christopher A., Margolis, Russell L., Chen, Gong, Kosik, Kenneth S., Song, Hongjun, Ming, Guo-li

“…Generation and neural differentiation of induced pluripotent stem cells (iPS cells) from patients enables new ways to investigate the cellular pathophysiology…”
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Huntington disease: natural history, biomarkers and prospects for therapeutics by Ross, Christopher A., Aylward, Elizabeth H., Wild, Edward J., Langbehn, Douglas R., Long, Jeffrey D., Warner, John H., Scahill, Rachael I., Leavitt, Blair R., Stout, Julie C., Paulsen, Jane S., Reilmann, Ralf, Unschuld, Paul G., Wexler, Alice, Margolis, Russell L., Tabrizi, Sarah J.

“…Key Points No disease-modifying treatments are currently available for Huntington disease (HD), but clinical trials of potential compounds are imminent;…”
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Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor by Eddings, Chelsy R., Arbez, Nicolas, Akimov, Sergey, Geva, Michal, Hayden, Michael R., Ross, Christopher A.

“…Huntington's disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene (HTT), translated into a Huntingtin protein…”
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What is the role of protein aggregation in neurodegeneration? by Ross, Christopher A, Poirier, Michelle A

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Prediction of manifest Huntington's disease with clinical and imaging measures: a prospective observational study by Paulsen, Jane S, Dr Prof, Long, Jeffrey D, Prof, Ross, Christopher A, Prof, Harrington, Deborah L, Prof, Erwin, Cheryl J, JD, Williams, Janet K, Prof, Westervelt, Holly James, PhD, Johnson, Hans J, PhD, Aylward, Elizabeth H, PhD, Zhang, Ying, Prof, Bockholt, H Jeremy, BS, Barker, Roger A, Prof

“…Summary Background Although the association between cytosine-adenine-guanine (CAG) repeat length and age at onset of Huntington's disease is well known,…”
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease by Gomez-Pastor, Rocio, Burchfiel, Eileen T., Neef, Daniel W., Jaeger, Alex M., Cabiscol, Elisa, McKinstry, Spencer U., Doss, Argenia, Aballay, Alejandro, Lo, Donald C., Akimov, Sergey S., Ross, Christopher A., Eroglu, Cagla, Thiele, Dennis J.

“…Huntington’s Disease (HD) is a neurodegenerative disease caused by poly-glutamine expansion in the Htt protein, resulting in Htt misfolding and cell death…”
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Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington's disease patient cells by Juopperi, Tarja A, Kim, Woon Ryoung, Chiang, Cheng-Hsuan, Yu, Huimei, Margolis, Russell L, Ross, Christopher A, Ming, Guo-li, Song, Hongjun

“…Huntington's Disease (HD) is a devastating neurodegenerative disorder that clinically manifests as motor dysfunction, cognitive impairment and psychiatric…”
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Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain by MANCHANG LIU, YIDENG LIANG, CHIGURUPATI, Srinivasulu, LATHIA, Justin D, PLETNIKOV, Mikhail, ZHAOLI SUN, CROW, Michael, ROSS, Christopher A, MATTSON, Mark P, RABB, Hamid

“…Although neurologic sequelae of acute kidney injury (AKI) are well described, the pathogenesis of acute uremic encephalopathy is poorly understood. This study…”
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Kinase activity of mutant LRRK2 mediates neuronal toxicity by Smith, Wanli W, Ross, Christopher A, Pei, Zhong, Jiang, Haibing, Dawson, Valina L, Dawson, Ted M

“…Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we…”
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Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity by Arbez, Nicolas, Ratovitski, Tamara, Roby, Elaine, Chighladze, Ekaterine, Stewart, Jacqueline C., Ren, Mark, Wang, Xiaofang, Lavery, Daniel J., Ross, Christopher A.

“…Huntington's disease (HD) is caused in large part by a polyglutamine expansion within the huntingtin (Htt) protein. Post-translational modifications (PTMs)…”
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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models by Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A

“…Phosphorylation of the N‐terminal domain of the huntingtin (HTT) protein has emerged as an important regulator of its localization, structure, aggregation,…”
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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets by Jiang, Mali, Wang, Jiawei, Fu, Jinrong, Du, Lin, Jeong, Hyunkyung, West, Tim, Xiang, Lan, Peng, Qi, Hou, Zhipeng, Cai, Huan, Seredenina, Tamara, Arbez, Nicolas, Zhu, Shanshan, Sommers, Katherine, Qian, Jennifer, Zhang, Jiangyang, Mori, Susumu, Yang, X William, Tamashiro, Kellie L K, Aja, Susan, Moran, Timothy H, Luthi-Carter, Ruth, Martin, Bronwen, Maudsley, Stuart, Mattson, Mark P, Cichewicz, Robert H, Ross, Christopher A, Holtzman, David M, Krainc, Dimitri, Duan, Wenzhen

“…Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan…”
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Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism by Liu, Zhaohui, Yu, Yi, Li, Xueping, Ross, Christopher A., Smith, Wanli W.

“…Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy…”
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Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis by Ratovitski, Tamara, Chighladze, Ekaterine, Arbez, Nicolas, Boronina, Tatiana, Herbrich, Shelley, Cole, Robert N., Ross, Christopher A.

“…Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of a polyglutamine repeat within the HD gene product, huntingtin. Huntingtin, a…”
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Targeting H3K4 trimethylation in Huntington disease by Vashishtha, Malini, Ng, Christopher W, Yildirim, Ferah, Gipson, Theresa A, Kratter, Ian H, Bodai, Laszlo, Song, Wan, Lau, Alice, Labadorf, Adam, Vogel-Ciernia, Annie, Troncosco, Juan, Ross, Christopher A, Bates, Gillian P, Krainc, Dimitri, Sadri-Vakili, Ghazaleh, Finkbeiner, Steven, Marsh, J Lawrence, Housman, David E, Fraenkel, Ernest, Thompson, Leslie M

“…Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3)…”
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Parkinson's Disease-Associated Mutations in Leucine-Rich Repeat Kinase 2 Augment Kinase Activity by Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Smith, Wanli W., Ross, Christopher A., Dawson, Valina L., Dawson, Ted M.

“…Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's disease (PD) with a clinical appearance indistinguishable from…”
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