Search Results - "Ross, Christina R."

Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer by Majocha, Megan R, Jackson, Devin E, Ha, Ngoc-Han, Amin, Ruhul, Pangrácová, Marie, Ross, Christina R, Yang, Howard H, Lee, Maxwell P, Hunter, Kent W

“…Patients with ER-negative breast cancer have the worst prognosis of all breast cancer subtypes, often experiencing rapid recurrence or progression to…”
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A Dimer Interface Mutation in Glyceraldehyde-3-Phosphate Dehydrogenase Regulates Its Binding to AU-rich RNA by White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

“…Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme best known for its role in glycolysis. However, extra-glycolytic functions of GAPDH have been…”
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Alternatively Expressed Domains of AU-rich Element RNA-binding Protein 1 (AUF1) Regulate RNA-binding Affinity, RNA-induced Protein Oligomerization, and the Local Conformation of Bound RNA Ligands by Zucconi, Beth E., Ballin, Jeff D., Brewer, Brandy Y., Ross, Christina R., Huang, Jun, Toth, Eric A., Wilson, Gerald M.

“…AU-rich element RNA-binding protein 1 (AUF1) binding to AU-rich elements (AREs) in the 3′-untranslated regions of mRNAs encoding many cytokines and other…”
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Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines by Temburnikar, Kartik W., Ross, Christina R., Wilson, Gerald M., Balzarini, Jan, Cawrse, Brian M., Seley-Radtke, Katherine L.

“…[Display omitted] In vitro evaluation of the halogenated pyrrolo[3,2-d]pyrimidines identified antiproliferative activities in compounds 1 and 2 against four…”
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Coordinated expression of tristetraprolin post-transcriptionally attenuates mitogenic induction of the oncogenic Ser/Thr kinase Pim-1 by Mahat, Dig B, Brennan-Laun, Sarah E, Fialcowitz-White, Elizabeth J, Kishor, Aparna, Ross, Christina R, Pozharskaya, Tatyana, Rawn, J David, Blackshear, Perry J, Hassel, Bret A, Wilson, Gerald M

“…The serine/threonine kinase Pim-1 directs selected signaling events that promote cell growth and survival and is overexpressed in diverse human cancers. Pim-1…”
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Tristetraprolin: Roles in cancer and senescence by Ross, Christina R, Brennan-Laun, Sarah E, Wilson, Gerald M

“…Highlights ► Tristetraprolin (TTP) binds mRNAs containing AU-rich elements (AREs) and targets them for rapid mRNA decay. ► TTP expression and/or activity are…”
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Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway by Xu, Li, Ning, Huan, Gu, Ling, Wang, Qinghong, Lu, Wenbao, Peng, Hui, Cui, Weiguang, Ying, Baoling, Ross, Christina R, Wilson, Gerald M, Wei, Lin, Wold, William S M, Liu, Jianguo

“…The main characteristic of cancers, including breast cancer, is the ability of cancer cells to proliferate uncontrollably. However, the underlying mechanisms…”
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Mitotic arrest of breast cancer MDA-MB-231 cells by a halogenated thieno[3,2-d]pyrimidine by Ross, Christina R, Temburnikar, Kartik W, Wilson, Gerald M, Seley-Radtke, Katherine L

“…Halogenated thieno[3,2-d]pyrimidines exhibit antiproliferative activity against a variety of cancer cell models, such as the mouse lymphocytic leukemia cell…”
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Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines by Temburnikar, Kartik W., Zimmermann, Sarah C., Kim, Nathaniel T., Ross, Christina R., Gelbmann, Christopher, Salomon, Christine E., Wilson, Gerald M., Balzarini, Jan, Seley-Radtke, Katherine L.

“…The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer…”
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A dimer interface mutation in glyceraldehyde 3-phosphate dehydrogenase regulates its binding to AU-rich RNA by White, Michael R., Khan, Mohd M., Deredge, Daniel, Ross, Christina R., Quintyn, Royston, Zucconi, Beth E., Wysocki, Vicki H., Wintrode, Patrick L., Wilson, Gerald M., Garcin, Elsa D.

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Contributions of the Histidine Side Chain and the N-Terminal α-Amino Group to the Binding Thermodynamics of Oligopeptides to Nucleic Acids as a Function of pH by Ballin, Jeff D, Prevas, James P, Ross, Christina R, Toth, Eric A, Wilson, Gerald M, Record, M. Thomas

“…Interactions of histidine with nucleic acid phosphates and histidine pK a shifts make important contributions to many protein−nucleic acid binding processes…”
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Contributions of the Histidine Side Chain and the N-Terminal a-Amino Group to the Binding Thermodynamics of Oligopeptides to Nucleic Acids as a Function of pH by Ballin, Jeff D, Prevas, James P, Ross, Christina R, Toth, Eric A, Wilson, Gerald M, Jr, M Thomas Record

“…Interactions of histidine with nucleic acid phosphates and histidine pKa shifts make important contributions to many protein-nucleic acid binding processes. To…”
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Resf1 is a compound G4 quadruplex-associated tumor suppressor for triple negative breast cancer by Megan R. Majocha, Devin E. Jackson, Ngoc-Han Ha, Ruhul Amin, Marie Pangrácová, Christina R. Ross, Howard H. Yang, Maxwell P. Lee, Kent W. Hunter

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Abstract 1970: The mRNA-destabilizing protein tristetraprolin suppresses tumorigenic phenotypes in a triple-negative breast cancer cell model via a non-canonical mechanism by Ross, Christina R., Wilson, Gerald M.

“…Abstract The purpose of this study was to define mechanisms by which the mRNA-destabilizing factor tristetraprolin (TTP) impacts tumorigenic phenotypes in an…”
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Abstract 3296: Tumor suppressive effects of tristetraprolin expression in metastatic breast cancer by Ross, Christina R., Wilson, Gerald M.

“…Abstract The purpose of this study is to define mechanisms by which the mRNA-destabilizing factor tristetraprolin (TTP) impacts tumorigenic phenotypes in an…”
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Abstract 5634: Tristetraprolin induces an antitumorigenic phenotype in triple negative breast cancer via a novel non-canonical mechanism by Rutherford, Julia L., Stemberger, Megan B., Mahmud, Rohaan, Ross, Christina R., White, Elizabeth J., Wilson, Gerald M.

“…Abstract The ultimate cause of death for most triple negative breast cancer (TNBC) patients is metastatic disease, which has a five-year survival rate of…”
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