Search Results - "Ross, Alastair D Mackenzie"

Enriched circulating and tumor-resident TGF-β+ regulatory B cells in patients with melanoma promote FOXP3+ Tregs by Harris, Robert J, Willsmore, Zena, Laddach, Roman, Crescioli, Silvia, Chauhan, Jitesh, Cheung, Anthony, Black, Anna, Geh, Jenny L. C., MacKenzie Ross, Alastair D, Healy, Ciaran, Tsoka, Sophia, Spicer, James, Lacy, Katie E, Karagiannis, Sophia N

“…B cells are emerging as key players of anti-tumor adaptive immune responses. We investigated regulatory and pro-inflammatory cytokine-expressing B cells in…”
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Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies by Adams, Rebecca, Osborn, Gabriel, Mukhia, Bipashna, Laddach, Roman, Willsmore, Zena, Chenoweth, Alicia, Geh, Jenny L C, MacKenzie Ross, Alastair D, Healy, Ciaran, Barber, Linda, Tsoka, Sophia, Sanz-Moreno, Victoria, Lacy, Katie E, Karagiannis, Sophia N

“…The application of monoclonal antibodies (mAbs) for the treatment of melanoma has significantly improved the clinical management of this malignancy over the…”
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The Association Between Excision Margins and Local Recurrence in 11,290 Thin (T1) Primary Cutaneous Melanomas: A Case–Control Study by MacKenzie Ross, Alastair D., Haydu, Lauren E., Quinn, Michael J., Saw, Robyn P. M., Shannon, Kerwin F., Spillane, Andrew J., Stretch, Jonathan R., Scolyer, Richard A., Thompson, John F.

“…Background At presentation, most primary cutaneous melanomas are “thin” (Breslow thickness ≤1 mm, designated T1 in the American Joint Committee on Cancer…”
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The Cake Flap: A new technique for serial excision of benign cutaneous lesions by Tang, Lydia, MacKenzie Ross, Alastair D, Nduka, Charles

“…Summary Large congenital melanocytic naevi and other circular benign skin lesions are often excised by serial ellipses in stages. With this conventional…”
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Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression by Soo, Julia K., MacKenzie Ross, Alastair D., Kallenberg, David M., Milagre, Carla, Heung Chong, W., Chow, Jade, Hill, Lucy, Hoare, Stacey, Collinson, Rebecca S., Hossain, Mehnaz, Keith, W. Nicol, Marais, Richard, Bennett, Dorothy C.

“…Summary Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear…”
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Isolation and culture of melanoma and naevus cells and cell lines by Soo, Julia K, Ross, Alastair D Mackenzie, Bennett, Dorothy C

“…Recently developed methods are described for the culture of cells from primary human melanomas and benign or dysplastic naevi (moles). These allow the culture…”
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Anti-cancer pro-inflammatory effects of an IgE antibody targeting the melanoma-associated antigen chondroitin sulfate proteoglycan 4 by Chauhan, Jitesh, Grandits, Melanie, Palhares, Lais C. G. F., Mele, Silvia, Nakamura, Mano, López-Abente, Jacobo, Crescioli, Silvia, Laddach, Roman, Romero-Clavijo, Pablo, Cheung, Anthony, Stavraka, Chara, Chenoweth, Alicia M., Sow, Heng Sheng, Chiaruttini, Giulia, Gilbert, Amy E., Dodev, Tihomir, Koers, Alexander, Pellizzari, Giulia, Ilieva, Kristina M., Man, Francis, Ali, Niwa, Hobbs, Carl, Lombardi, Sara, Lionarons, Daniël A., Gould, Hannah J., Beavil, Andrew J., Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Calonje, Eduardo, Downward, Julian, Nestle, Frank O., Tsoka, Sophia, Josephs, Debra H., Blower, Philip J., Karagiannis, Panagiotis, Lacy, Katie E., Spicer, James, Karagiannis, Sophia N., Bax, Heather J.

“…Outcomes for half of patients with melanoma remain poor despite standard-of-care checkpoint inhibitor therapies. The prevalence of the melanoma-associated…”
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Tumor associated macrophages as key contributors and targets in current and future therapies for melanoma by Habib, Shabana, Osborn, Gabriel, Willsmore, Zena, Chew, Min Waye, Jakubow, Sophie, Fitzpatrick, Amanda, Wu, Yin, Sinha, Khushboo, Lloyd-Hughes, Hawys, Geh, Jenny L C, MacKenzie-Ross, Alastair D, Whittaker, Sean, Sanz-Moreno, Victoria, Lacy, Katie E, Karagiannis, Sophia N, Adams, Rebecca

“…Despite the success of immunotherapies for melanoma in recent years, there remains a significant proportion of patients who do not yet derive benefit from…”
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BRAF inhibitors and their immunological effects in malignant melanoma by Adams, Rebecca, Coumbe, Jack E M, Coumbe, Ben G T, Thomas, Jennifer, Willsmore, Zena, Dimitrievska, Marija, Yasuzawa-Parker, Monica, Hoyle, Maximilian, Ingar, Suhaylah, Geh, Jenny L C, MacKenzie Ross, Alastair D, Healy, Ciaran, Papa, Sophie, Lacy, Katie E, Karagiannis, Sophia N

“…The treatment of cutaneous melanoma has been revolutionized by the development of small-molecule inhibitors targeting the MAPK pathway, including inhibitors of…”
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Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression by MacKenzie Ross, Alastair D., Cook, Martin G., Chong, Heung, Hossain, Mehnaz, Pandha, Hardev S., Bennett, Dorothy C.

“…Summary The best‐established function of the melanoma‐suppressor p16 is mediation of cell senescence, a permanent arrest following cell proliferation or…”
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O20 Advanced melanoma is associated with distinct circulating B-cell profiles enriched with immunoregulatory and autoreactive features by Willsmore, Zena, Crescioli, Silvia, Booth, Lucy, Laddach, Roman, Yorke, Rozalyn, Harris, Robert , Chauhan, Jitesh, Chenoweth, Alicia , Adams, Rebecca , Osborn, Gabriel, Di Meo, Ashley , Prassas, Ioannis, Geh, Jenny L C, Patel, Akshay J  , Middleton, Gary W, MacKenzie Ross, Alastair D  , Healey, Ciaran, Diamandis, Eleftherios P, Sinha, Khushboo, Wu, Yin, Whittaker, Sean J, Perucha, Esperanza, Papa, Sophie, Lacy, Katie E  , Karagiannis, Sophia N

“…Abstract There is increasing evidence that B cells play a significant role in the immunobiology of melanoma; however, reports of the pro- vs. antitumour roles…”
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B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma by Crescioli, Silvia, Correa, Isabel, Ng, Joseph, Willsmore, Zena N., Laddach, Roman, Chenoweth, Alicia, Chauhan, Jitesh, Di Meo, Ashley, Stewart, Alexander, Kalliolia, Eleni, Alberts, Elena, Adams, Rebecca, Harris, Robert J., Mele, Silvia, Pellizzari, Giulia, Black, Anna B. M., Bax, Heather J., Cheung, Anthony, Nakamura, Mano, Hoffmann, Ricarda M., Terranova-Barberio, Manuela, Ali, Niwa, Batruch, Ihor, Soosaipillai, Antoninus, Prassas, Ioannis, Ulndreaj, Antigona, Chatanaka, Miyo K., Nuamah, Rosamund, Kannambath, Shichina, Dhami, Pawan, Geh, Jenny L. C., MacKenzie Ross, Alastair D., Healy, Ciaran, Grigoriadis, Anita, Kipling, David, Karagiannis, Panagiotis, Dunn-Walters, Deborah K., Diamandis, Eleftherios P., Tsoka, Sophia, Spicer, James, Lacy, Katie E., Fraternali, Franca, Karagiannis, Sophia N.

“…B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been…”
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