Search Results - "Rosner, Kristin E."

Discovery and SAR of hydantoin TACE inhibitors by Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei

“…A novel series of hydantoin TACE inhibitors is disclosed. The initial design and SAR optimization of the series, as well as accompanying X-ray structural and…”
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Pyrazolo[1,5- a]pyrimidine-based inhibitors of HCV polymerase by Popovici-Muller, Janeta, Shipps, Gerald W., Rosner, Kristin E., Deng, Yongqi, Wang, Tong, Curran, Patrick J., Brown, Meredith A., Siddiqui, M. Arshad, Cooper, Alan B., Duca, José, Cable, Michael, Girijavallabhan, Viyyoor

“…Synthesis and optimization of novel pyrazolo[1,5- a]pyrimidine HCV polymerase inhibitors are described. The present paper describes a novel series of HCV RNA…”
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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors by Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad

“…TNF-α converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE…”
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Biaryl substituted hydantoin compounds as TACE inhibitors by Yu, Wensheng, Tong, Ling, Kim, Seong Heon, Wong, Michael K.C., Chen, Lei, Yang, De-Yi, Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Kosinski, Aneta, Rizvi, Razia, Li, Dansu, Feltz, Robert J., Piwinski, John J., Rosner, Kristin E., Shih, Neng-Yang, Siddiqui, M. Arshad, Guo, Zhuyan, Orth, Peter, Shah, Himanshu, Sun, Jing, Umland, Shelby, Lundell, Daniel J., Niu, Xiaoda, Kozlowski, Joseph A.

“…A series of biaryl substituted hydantoin TACE inhibitors is disclosed. Many compounds in this series exhibit sub-nanomolar TACE activities and good rat PK. We…”
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Discovery of 4H-pyrazolo[1,5-a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase by YONGQI DENG, SHIPPS, Gerald W, TONG WANG, POPOVICI-MULLER, Janeta, ROSNER, Kristin E, ARSHAD SIDDIQUI, M, DUCA, Jose, COOPER, Alan B, CABLE, Michael

“…A series of 4H-pyrazolo[1,5-a]pyrimidin-7-one derivatives was synthesized and evaluated for inhibitory activity against HCV NS5B RNA-dependent RNA polymerase…”
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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors by Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.

“…Synthesis and optimization of novel tartrate TACE inhibitors are described. A novel series of TNF-α convertase (TACE) inhibitors which are non-hydroxamate have…”
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Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases by Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby

“…Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency ( K…”
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Structure and activity relationships of tartrate-based TACE inhibitors by Li, Dansu, Popovici-Muller, Janeta, Belanger, David B., Caldwell, John, Dai, Chaoyang, David, Maria, Girijavallabhan, Vinay M., Lavey, Brian J., Lee, Joe F., Liu, Zhidan, Mazzola, Rob, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle, Spitler, Jim, Ting, Pauline C., Vaccaro, Henry, Yu, Wensheng, Zhou, Guowei, Zhu, Zhaoning, Niu, Xiaoda, Sun, Jing, Guo, Zhuyan, Orth, Peter, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng-Yang, Shipps, Gerald W., Siddiqui, M. Arshad, Strickland, Corey O.

“…The syntheses and structure–activity relationships of the tartrate-based TACE inhibitors are discussed. The optimization of both the prime and non-prime sites…”
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The discovery of novel tartrate-based TNF-a converting enzyme (TACE) inhibitors by Rosner, Kristin E, Guo, Zhuyan, Orth, Peter, Shipps, Gerald W, Belanger, David B, Chan, Tin Yau, Curran, Patrick J, Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M, Hong, Liwu, Lavey, Brian J, Lee, Joe F, Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C, Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A, Lundell, Daniel J, Madison, Vincent, McKittrick, Brian, Piwinski, John J, Shih, Neng-Yang, Siddiqui, MArshad, Strickland, Corey O

“…A novel series of TNF-a convertase (TACE) inhibitors which are non-hydroxamate have been discovered. These compounds are bis-amides of l-tartaric acid…”
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Aminothiazole inhibitors of HCV RNA polymerase by Shipps, Gerald W., Deng, Yongqi, Wang, Tong, Popovici-Muller, Janeta, Curran, Patrick J., Rosner, Kristin E., Cooper, Alan B., Girijavallabhan, Viyyoor, Butkiewicz, Nancy, Cable, Michael

“…[Display omitted] Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a…”
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An affinity selection–mass spectrometry method for the identification of small molecule ligands from self-encoded combinatorial libraries by Annis, D. Allen, Athanasopoulos, John, Curran, Patrick J., Felsch, Jason S., Kalghatgi, Krishna, Lee, William H., Nash, Huw M., Orminati, Jean-Paul A., Rosner, Kristin E., Shipps, Gerald W., Thaddupathy, G.R.A., Tyler, Andrew N., Vilenchik, Lev, Wagner, Carston R., Wintner, Edward A.

“…The NeoGenesis Automated Ligand Identification System (ALIS), an affinity selection–mass spectrometry (AS–MS) process consisting of a rapid size-exclusion…”
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Discovery of 4 H-pyrazolo[1,5- a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase by Deng, Yongqi, Shipps, Gerald W., Wang, Tong, Popovici-Muller, Janeta, Rosner, Kristin E., Siddiqui, M. Arshad, Duca, Jose, Cooper, Alan B., Cable, Michael

“…The design, synthesis and evaluation of a series of 4 H-Pyrazolo[1,5- a]pyrimidin-7-ones as potent inhibitors of hepatitis C virus polymerase are described. A…”
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The synthesis of 6,9-bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline-, benzo[g]quinazoline- and benzo-[g]phthalazine-5,10-diones via regiospecific displacements by Krapcho, A. Paul, Maresch, Martin J., Helgason, Anna L., Rosner, Kristin E., Hacker, Miles P., Spinelli, Silvano, Menta, Ernesto, Oliva, Ambrogio

“…The synthesis of 6,9‐difluoro substituted benzo[g]quinoxaline‐5,10‐diones (3A), benzo[g]quinazoline‐5,10‐diones (3B) and benzo[g]phthalazine‐5,10‐diones (3C)…”
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