Search Results - "Rosin, Leah F."
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Uncharted territories: Solving the mysteries of male meiosis in flies
Published in PLoS genetics (15-03-2024)“…The segregation of homologous chromosomes during meiosis typically requires tight end-to-end chromosome pairing. However, in Drosophila spermatogenesis, male…”
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Condensin II drives large-scale folding and spatial partitioning of interphase chromosomes in Drosophila nuclei
Published in PLoS genetics (12-07-2018)“…Metazoan chromosomes are folded into discrete sub-nuclear domains, referred to as chromosome territories (CTs). The molecular mechanisms that underlie the…”
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M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity
Published in Nature communications (07-07-2021)“…Genome organization is driven by forces affecting transcriptional state, but the relationship between transcription and genome architecture remains unclear…”
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Chromosome segregation during spermatogenesis occurs through a unique center-kinetic mechanism in holocentric moth species
Published in PLoS genetics (24-06-2024)“…Precise regulation of chromosome dynamics in the germline is essential for reproductive success across species. Yet, the mechanisms underlying meiotic…”
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Oligopaint DNA FISH reveals telomere-based meiotic pairing dynamics in the silkworm, Bombyx mori
Published in PLoS genetics (28-07-2021)“…Accurate chromosome segregation during meiosis is essential for reproductive success. Yet, many fundamental aspects of meiosis remain unclear, including the…”
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Chromosome territory formation attenuates the translocation potential of cells
Published in eLife (04-11-2019)“…The formation and spatial arrangement of chromosome territories (CTs) in interphase has been posited to influence the outcome and frequency of genomic…”
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Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males
Published in Proceedings of the National Academy of Sciences - PNAS (08-03-2022)“…SignificanceGenes on sex chromosomes (i.e. human chX) are regulated differently in males and females to balance gene expression levels between sexes (XY vs…”
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Centromeres Drive a Hard Bargain
Published in Trends in genetics (01-02-2017)“…Centromeres are essential chromosomal structures that mediate the accurate distribution of genetic material during meiotic and mitotic cell divisions. In most…”
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NURF301 contributes to gypsy chromatin insulator-mediated nuclear organization
Published in Nucleic acids research (12-08-2022)“…Abstract Chromatin insulators are DNA-protein complexes that can prevent the spread of repressive chromatin and block communication between enhancers and…”
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