Search Results - "Rosin, Jessica M"

A subpopulation of embryonic microglia respond to maternal stress and influence nearby neural progenitors by Rosin, Jessica M., Sinha, Sarthak, Biernaskie, Jeff, Kurrasch, Deborah M.

“…The interplay between hypothalamic neurons and microglia as they integrate stressors to regulate homeostasis is of growing interest. We asked if microglia in…”
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Emerging roles for hypothalamic microglia as regulators of physiological homeostasis by Rosin, Jessica M., Kurrasch, Deborah M.

“…•Microglia play important roles in both the development and continued function of the hypothalamus throughout life.•Microglia could be key regulators of…”
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In utero electroporation induces cell death and alters embryonic microglia morphology and expression signatures in the developing hypothalamus by Rosin, Jessica M, Kurrasch, Deborah M

“…Since its inception in 2001, in utero electroporation (IUE) has been widely used by the neuroscience community. IUE is a technique developed to introduce…”
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Editorial: Insights in non-neuronal cells: 2022 by Rosin, Jessica M, Tremblay, Marie-Ève, Plemel, Jason R

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Editorial: Insights in non-neuronal cells: 2021 by Plemel, Jason R, Rosin, Jessica M, Tremblay, Marie-Ève

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Gestational Bisphenol A Exposure Impacts Embryonic Hypothalamic Microglia Numbers, Ramification, and Phagocytic Cups by Rosin, Jessica M, Tretiakov, Nikol, Hanniman, Emily, Hampton, Kiana, Kurrasch, Deborah M

“…Microglia are a resident population of phagocytic immune cells that reside within the central nervous system (CNS). During gestation, they are highly sensitive…”
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Live-cell imaging of microglial interactions with radial glia in transgenic embryonic mouse brains using slice culture by Rosin, Jessica M., Malik, Faizan, Kurrasch, Deborah M.

“…Microglial dynamics and interactions with nearby radial glia can be visualized in real time in embryonic mouse brain tissue using time-lapse imaging in slice…”
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Shox2 is required for the proper development of the facial motor nucleus and the establishment of the facial nerves by Rosin, Jessica M, Kurrasch, Deborah M, Cobb, John

“…Axons from the visceral motor neurons (vMNs) project from nuclei in the hindbrain to innervate autonomic ganglia and branchial arch-derived muscles. Although…”
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A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development by Neufeld, Stanley, Rosin, Jessica M., Ambasta, Anshula, Hui, Kristen, Shaneman, Venessa, Crowder, Ray, Vickerman, Lori, Cobb, John

“…R‐spondins are secreted ligands that bind cell surface receptors and activate Wnt/β‐catenin signaling. Human mutations and gene inactivation studies in mice…”
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Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination by Rosin, Jessica M., McAllister, Brendan B., Dyck, Richard H., Percival, Christopher J., Kurrasch, Deborah M., Cobb, John

“…Purkinje cells of the developing cerebellum secrete the morphogen sonic hedgehog (SHH), which is required to maintain the proliferative state of granule cell…”
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Depletion of embryonic microglia using the CSF1R inhibitor PLX5622 has adverse sex-specific effects on mice, including accelerated weight gain, hyperactivity and anxiolytic-like behaviour by Rosin, Jessica M., Vora, Siddharth R., Kurrasch, Deborah M.

“…•The CSF1R inhibitor PLX5622 depleted ∼99% of fetal microglia by E15.5.•Embryonic microglia depletion resulted in a decreased litter size.•Elimination of…”
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Embryonic inhibition of colony‐stimulating factor 1 receptor impacts craniofacial morphogenesis by Nagra, Ashina, Katsube, Motoki, Gao, Wade, Rosin, Jessica M., Vora, Siddharth R.

“…Objectives Colony‐stimulating factor‐1 receptor (CSF1R) is vital for the recruitment of monocytes, and their proliferation and differentiation into functional…”
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Bisphenol A and microglia: could microglia be responsive to this environmental contaminant during neural development? by Rosin, Jessica M, Kurrasch, Deborah M

“…There is a growing interest in the functional role of microglia in the developing brain. In our laboratory, we have become particularly intrigued as to whether…”
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Ascl1 is required to specify a subset of ventromedial hypothalamic neurons by Aslanpour, Shaghayegh, Rosin, Jessica M, Balakrishnan, Anjali, Klenin, Natalia, Blot, Florence, Gradwohl, Gerard, Schuurmans, Carol, Kurrasch, Deborah M

“…Despite clear physiological roles, the ventromedial hypothalamus (VMH) developmental programs are poorly understood. Here, we asked whether the proneural gene…”
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Embryonic Microglia Interact with Hypothalamic Radial Glia during Development and Upregulate the TAM Receptors MERTK and AXL following an Insult by Rosin, Jessica M., Marsters, Candace M., Malik, Faizan, Far, Rena, Adnani, Lata, Schuurmans, Carol, Pittman, Quentin J., Kurrasch, Deborah M.

“…Despite a growing appreciation for microglial influences on the developing brain, the responsiveness of microglia to insults during gestation remains less well…”
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Identification of a limb enhancer that is removed by pathogenic deletions downstream of the SHOX gene by Skuplik, Isabella, Benito-Sanz, Sara, Rosin, Jessica M., Bobick, Brent E., Heath, Karen E., Cobb, John

“…Haploinsufficiency of the human SHOX gene causes Léri-Weill dyschondrosteosis (LWD), characterized by shortening of the middle segments of the limbs and…”
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Ascl1 is required to specify a subset of ventromedial hypothalamic neurons by Aslanpour, Shaghayegh, Rosin, Jessica M, Balakrishnan, Anjali, Klenin, Natalia, Blot, Florence, Gradwohl, Gerard, Schuurmans, Carol, Kurrasch, Deborah M

“…Despite clear physiological roles, the ventromedial hypothalamus (VMH) developmental programs are poorly understood. Here, we asked whether the proneural gene,…”
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A distal 594 bp ECR specifies Hmx1 expression in pinna and lateral facial morphogenesis and is regulated by the Hox-Pbx-Meis complex by Rosin, Jessica M, Li, Wenjie, Cox, Liza L, Rolfe, Sara M, Latorre, Victor, Akiyama, Jennifer A, Visel, Axel, Kuramoto, Takashi, Bobola, Nicoletta, Turner, Eric E, Cox, Timothy C

“…Hmx1 encodes a homeodomain transcription factor expressed in the developing lateral craniofacial mesenchyme, retina and sensory ganglia. Mutation or…”
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Comparative transgenic analysis of enhancers from the human SHOX and mouse Shox2 genomic regions by Rosin, Jessica M, Abassah-Oppong, Samuel, Cobb, John

“…Disruption of presumptive enhancers downstream of the human SHOX gene (hSHOX) is a frequent cause of the zeugopodal limb defects characteristic of Léri-Weill…”
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Oligodendrocyte development in the embryonic tuberal hypothalamus and the influence of Ascl1 by Marsters, Candace M, Rosin, Jessica M, Thornton, Hayley F, Aslanpour, Shaghayegh, Klenin, Natasha, Wilkinson, Grey, Schuurmans, Carol, Pittman, Quentin J, Kurrasch, Deborah M

“…Although the vast majority of cells in our brains are glia, we are only beginning to understand programs governing their development, especially within the…”
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