Search Results - "Rosin, Diane L."

Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes by Inoue, Tsuyoshi, Abe, Chikara, Sung, Sun-Sang J, Moscalu, Stefan, Jankowski, Jakub, Huang, Liping, Ye, Hong, Rosin, Diane L, Guyenet, Patrice G, Okusa, Mark D

“…The nervous and immune systems interact in complex ways to maintain homeostasis and respond to stress or injury, and rapid nerve conduction can provide…”
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C1 neurons mediate a stress-induced anti-inflammatory reflex in mice by Abe, Chikara, Inoue, Tsuyoshi, Inglis, Mabel A, Viar, Kenneth E, Huang, Liping, Ye, Hong, Rosin, Diane L, Stornetta, Ruth L, Okusa, Mark D, Guyenet, Patrice G

“…Acute stress elicits physiological and behavioral responses that enhance survival. This study in mice shows that stress reduces tissue injury in a model of…”
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Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI by Perry, Heather M, Huang, Liping, Wilson, Rebecca J, Bajwa, Amandeep, Sesaki, Hiromi, Yan, Zhen, Rosin, Diane L, Kashatus, David F, Okusa, Mark D

“…The proximal tubule epithelium relies on mitochondrial function for energy, rendering the kidney highly susceptible to ischemic AKI. Dynamin-related protein 1…”
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Targeting neural reflex circuits in immunity to treat kidney disease by Okusa, Mark D., Rosin, Diane L., Tracey, Kevin J.

“…Key Points Neural circuits that control immunity and inflammation provide novel targets for the treatment of kidney disease and hypertension Activation of the…”
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Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury by Tanaka, Shinji, Abe, Chikara, Abbott, Stephen B. G., Zheng, Shuqiu, Yamaoka, Yusuke, Lipsey, Jonathan E., Skrypnyk, Nataliya I., Yao, Junlan, Inoue, Tsuyoshi, Nash, William T., Stornetta, Daniel S., Rosin, Diane L., Stornetta, Ruth L., Guyenet, Patrice G., Okusa, Mark D.

“…Acute kidney injury is highly prevalent and associated with high morbidity and mortality, and there are no approved drugs for its prevention and treatment…”
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IL233, A Novel IL-2 and IL-33 Hybrid Cytokine, Ameliorates Renal Injury by Stremska, Marta E, Jose, Sheethal, Sabapathy, Vikram, Huang, Liping, Bajwa, Amandeep, Kinsey, Gilbert R, Sharma, Poonam R, Mohammad, Saleh, Rosin, Diane L, Okusa, Mark D, Sharma, Rahul

“…CD4 Foxp3 regulatory T cells (Tregs) protect the kidney during AKI. We previously found that IL-2, which is critical for Treg homeostasis, upregulates the…”
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Ultrasound Modulates the Splenic Neuroimmune Axis in Attenuating AKI by Gigliotti, Joseph C, Huang, Liping, Bajwa, Amandeep, Ye, Hong, Mace, Eric H, Hossack, John A, Kalantari, Kambiz, Inoue, Tsuyoshi, Rosin, Diane L, Okusa, Mark D

“…We showed previously that prior exposure to a modified ultrasound regimen prevents kidney ischemia-reperfusion injury (IRI) likely via the splenic cholinergic…”
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Non-canonical cholinergic anti-inflammatory pathway-mediated activation of peritoneal macrophages induces Hes1 and blocks ischemia/reperfusion injury in the kidney by Inoue, Tsuyoshi, Abe, Chikara, Kohro, Takahide, Tanaka, Shinji, Huang, Liping, Yao, Junlan, Zheng, Shuqiu, Ye, Hong, Inagi, Reiko, Stornetta, Ruth L, Rosin, Diane L, Nangaku, Masaomi, Wada, Youichiro, Okusa, Mark D

“…The cholinergic anti-inflammatory pathway (CAP) links the nervous and immune systems and modulates innate and adaptive immunity. Activation of the CAP by vagus…”
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Sphingosine 1-phosphate signaling in perivascular cells enhances inflammation and fibrosis in the kidney by Tanaka, Shinji, Zheng, Shuqiu, Kharel, Yugesh, Fritzemeier, Russell G, Huang, Tao, Foster, Daniel, Poudel, Nabin, Goggins, Eibhlin, Yamaoka, Yusuke, Rudnicka, Kinga P, Lipsey, Jonathan E, Radel, Hope V, Ryuh, Sophia M, Inoue, Tsuyoshi, Yao, Junlan, Rosin, Diane L, Schwab, Susan R, Santos, Webster L, Lynch, Kevin R, Okusa, Mark D

“…Chronic kidney disease (CKD), characterized by sustained inflammation and progressive fibrosis, is highly prevalent and can eventually progress to end-stage…”
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The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia–reperfusion injury by Li, Li, Huang, Liping, Sung, Sun-Sang J., Vergis, Amy L., Rosin, Diane L., Rose, C. Edward, Lobo, Peter I., Okusa, Mark D.

“…Chemokines and their receptors such as CCR2 and CX3CR1 mediate leukocyte adhesion and migration into injured tissue. To further define mechanisms of monocyte…”
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Epithelial and Endothelial Pannexin1 Channels Mediate AKI by Jankowski, Jakub, Perry, Heather M, Medina, Christopher B, Huang, Liping, Yao, Junlan, Bajwa, Amandeep, Lorenz, Ulrike M, Rosin, Diane L, Ravichandran, Kodi S, Isakson, Brant E, Okusa, Mark D

“…Pannexin1 (Panx1), an ATP release channel, is present in most mammalian tissues, but the role of Panx1 in health and disease is not fully understood. Panx1 may…”
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Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury by Bajwa, Amandeep, Huang, Liping, Kurmaeva, Elvira, Gigliotti, Joseph C, Ye, Hong, Miller, Jacqueline, Rosin, Diane L, Lobo, Peter I, Okusa, Mark D

“…The plasticity of dendritic cells (DCs) permits phenotypic modulation ex vivo by gene expression or pharmacologic agents, and these modified DCs can exert…”
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Endothelial Sphingosine 1‑Phosphate Receptor‑1 Mediates Protection and Recovery from Acute Kidney Injury by Perry, Heather M, Huang, Liping, Ye, Hong, Liu, Chong, Sung, Sun-Sang J, Lynch, Kevin R, Rosin, Diane L, Bajwa, Amandeep, Okusa, Mark D

“…Epithelial and endothelial injury and a cascade of immune and interstitial cell activation in the kidney lead to AKI. After mild to moderate AKI, the…”
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Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury by Bajwa, Amandeep, Rosin, Diane L, Chroscicki, Piotr, Lee, Sangju, Dondeti, Krishna, Ye, Hong, Kinsey, Gilbert R, Stevens, Brian K, Jobin, Katarzyna, Kenwood, Brandon M, Hoehn, Kyle L, Lynch, Kevin R, Okusa, Mark D

“…Sphingosine 1-phosphate (S1P), the natural sphingolipid ligand for a family of five G protein- coupled receptors (S1P1-S1P5Rs), regulates cell survival and…”
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Perivascular CD73 + cells attenuate inflammation and interstitial fibrosis in the kidney microenvironment by Perry, Heather M, Görldt, Nicole, Sung, Sun-Sang J, Huang, Liping, Rudnicka, Kinga P, Encarnacion, Iain M, Bajwa, Amandeep, Tanaka, Shinji, Poudel, Nabin, Yao, Junlan, Rosin, Diane L, Schrader, Jürgen, Okusa, Mark D

“…Progressive tubulointerstitial fibrosis may occur after acute kidney injury due to persistent inflammation. Purinergic signaling by 5'-ectonucleotidase, CD73,…”
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Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury by Bajwa, Amandeep, Huang, Liping, Ye, Hong, Dondeti, Krishna, Song, Steven, Rosin, Diane L, Lynch, Kevin R, Lobo, Peter I, Li, Li, Okusa, Mark D

“…Dendritic cells (DCs) are central to innate and adaptive immunity of early kidney ischemia-reperfusion injury (IRI), and strategies to alter DC function may…”
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Activation of Sphingosine-1-Phosphate 1 Receptor in the Proximal Tubule Protects Against Ischemia-Reperfusion Injury by BAJWA, Amandeep, JO, Sang-Kyung, HONG YE, LIPING HUANG, DONDETI, Krishna R, ROSIN, Diane L, HAASE, Volker H, MACDONALD, Timothy L, LYNCH, Kevin R, OKUSA, Mark D

“…Agonists of the sphingosine-1-phosphate receptor (S1PR) attenuate kidney ischemia-reperfusion injury (IRI). Previous studies suggested that S1P1R-induced…”
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Bioelectronic Approaches to Control Neuroimmune Interactions in Acute Kidney Injury by Inoue, Tsuyoshi, Tanaka, Shinji, Rosin, Diane L, Okusa, Mark D

“…Recent studies have shown renal protective effects of bioelectric approaches, including ultrasound treatment, electrical vagus nerve stimulation, and…”
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Serotonergic Neurons Activate Chemosensitive Retrotrapezoid Nucleus Neurons by a pH-Independent Mechanism by Mulkey, Daniel K, Rosin, Diane L, West, Gavin, Takakura, Ana C, Moreira, Thiago S, Bayliss, Douglas A, Guyenet, Patrice G

“…Serotonin activates respiration and enhances the stimulatory effect of CO2 on breathing. The present study tests whether the mechanism involves the…”
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Neuroimmunomodulation of tissue injury and disease: an expanding view of the inflammatory reflex pathway by Tanaka, Shinji, Hammond, Benjamin, Rosin, Diane L, Okusa, Mark D

“…Neuroimmunomodulation through peripheral nerve activation is an important therapeutic approach to various disorders. Central to this approach is the…”
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