Search Results - "Rosh, Idan"

Mood Stabilizers in Psychiatric Disorders and Mechanisms Learnt from In Vitro Model Systems by Nayak, Ritu, Rosh, Idan, Kustanovich, Irina, Stern, Shani

“…Bipolar disorder (BD) and schizophrenia are psychiatric disorders that manifest unusual mental, behavioral, and emotional patterns leading to suffering and…”
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IQSEC2 mutation associated with epilepsy, intellectual disability, and autism results in hyperexcitability of patient-derived neurons and deficient synaptic transmission by Brant, Boris, Stern, Tchelet, Shekhidem, Huda Adwan, Mizrahi, Liron, Rosh, Idan, Stern, Yam, Ofer, Polina, Asleh, Ayat, Umanah, George K. Essien, Jada, Reem, Levy, Nina S., Levy, Andrew P., Stern, Shani

“…Mutations in the IQSEC2 gene are associated with drug-resistant, multifocal infantile and childhood epilepsy; autism; and severe intellectual disability (ID)…”
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Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations by Hussein, Yara, Tripathi, Utkarsh, Choudhary, Ashwani, Nayak, Ritu, Peles, David, Rosh, Idan, Rabinski, Tatiana, Djamus, Jose, Vatine, Gad David, Spiegel, Ronen, Garin-Shkolnik, Tali, Stern, Shani

“…Autism Spectrum Disorder (ASD) is characterized mainly by social and sensory-motor abnormal and repetitive behavior patterns. Over hundreds of genes and…”
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Generation and characterization of iPSC lines (UOHi003-A, UOHi002-A) from a patient with SHANK3 mutation and her healthy mother by Nayak, Ritu, Rosh, Idan, Rabinski, Tatiana, Falik, Daniel, Mendel Percia, Menachem, Stern, Shani

“…Phelan-McDermid syndrome (PMS) is a rare genetic condition that causes global developmental disability, delayed or absent speech, and an autism spectrum…”
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NGLY1 mutations cause protein aggregation in human neurons by Manole, Andreea, Wong, Thomas, Rhee, Amanda, Novak, Sammy, Chin, Shao-Ming, Tsimring, Katya, Paucar, Andres, Williams, April, Newmeyer, Traci Fang, Schafer, Simon T., Rosh, Idan, Kaushik, Susmita, Hoffman, Rene, Chen, Songjie, Wang, Guangwen, Snyder, Michael, Cuervo, Ana Maria, Andrade, Leo, Manor, Uri, Lee, Kevin, Jones, Jeffrey R., Stern, Shani, Marchetto, Maria C., Gage, Fred H.

“…Biallelic mutations in the gene that encodes the enzyme N-glycanase 1 (NGLY1) cause a rare disease with multi-symptomatic features including developmental…”
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Upregulated ECM genes and increased synaptic activity in Parkinson’s human DA neurons with PINK1/ PRKN mutations by Tripathi, Utkarsh, Rosh, Idan, Ben Ezer, Ran, Nayak, Ritu, Hussein, Yara, Choudhary, Ashwani, Djamus, Jose, Manole, Andreea, Houlden, Henry, Gage, Fred H., Stern, Shani

“…Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. Primary symptoms of PD arise with the loss of dopaminergic (DA) neurons in the…”
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Synaptic dysfunction and extracellular matrix dysregulation in dopaminergic neurons from sporadic and E326K-GBA1 Parkinson’s disease patients by Rosh, Idan, Tripathi, Utkarsh, Hussein, Yara, Rike, Wote Amelo, Djamus, Jose, Shklyar, Boris, Manole, Andreea, Houlden, Henry, Winkler, Jurgen, Gage, Fred H., Stern, Shani

“…Parkinson’s disease (PD) is a neurodegenerative disease with both genetic and sporadic origins. In this study, we investigated the electrophysiological…”
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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients by Stern, Shani, Lau, Shong, Manole, Andreea, Rosh, Idan, Percia, Menachem Mendel, Ben Ezer, Ran, Shokhirev, Maxim N., Qiu, Fan, Schafer, Simon, Mansour, Abed AlFatah, Mangan, Kile P., Stern, Tchelet, Ofer, Polina, Stern, Yam, Diniz Mendes, Ana Paula, Djamus, Jose, Moore, Lynne Randolph, Nayak, Ritu, Laufer, Sapir Havusha, Aicher, Aidan, Rhee, Amanda, Wong, Thomas L., Nguyen, Thao, Linker, Sara B., Winner, Beate, Freitas, Beatriz C., Jones, Eugenia, Sagi, Irit, Bardy, Cedric, Brice, Alexis, Winkler, Juergen, Marchetto, Maria C., Gage, Fred H.

“…Several mutations that cause Parkinson’s disease (PD) have been identified over the past decade. These account for 15–25% of PD cases; the rest of the cases…”
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Brain‐Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha‐Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease by Sela, Mor, Poley, Maria, Mora‐Raimundo, Patricia, Kagan, Shaked, Avital, Aviram, Kaduri, Maya, Chen, Gal, Adir, Omer, Rozencweig, Adi, Weiss, Yfat, Sade, Ofir, Leichtmann‐Bardoogo, Yael, Simchi, Lilach, Aga‐Mizrachi, Shlomit, Bell, Batia, Yeretz‐Peretz, Yoel, Or, Aviv Zaid, Choudhary, Ashwani, Rosh, Idan, Cordeiro, Diogo, Cohen‐Adiv, Stav, Berdichevsky, Yevgeny, Odeh, Anas, Shklover, Jeny, Shainsky‐Roitman, Janna, Schroeder, Joshua E., Hershkovitz, Dov, Hasson, Peleg, Ashkenazi, Avraham, Stern, Shani, Laviv, Tal, Ben‐Zvi, Ayal, Avital, Avi, Ashery, Uri, Maoz, Ben M., Schroeder, Avi

“…Monoclonal antibodies (mAbs) hold promise in treating Parkinson's disease (PD), although poor delivery to the brain hinders their therapeutic application. In…”
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Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission by Stern, Shani, Zhang, Lei, Wang, Meiyan, Wright, Rebecca, Rosh, Idan, Hussein, Yara, Stern, Tchelet, Choudhary, Ashwani, Tripathi, Utkarsh, Reed, Patrick, Sadis, Hagit, Nayak, Ritu, Shemen, Aviram, Agarwal, Karishma, Cordeiro, Diogo, Peles, David, Hang, Yuqing, Mendes, Ana P. D., Baul, Tithi D., Roth, Julien G., Coorapati, Shashank, Boks, Marco P., McCombie, W. Richard, Hulshoff Pol, Hilleke, Brennand, Kristen J., Réthelyi, János M., Kahn, René S., Marchetto, Maria C., Gage, Fred H.

“…Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric…”
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Brain‐Targeted Liposomes Loaded with Monoclonal Antibodies Reduce Alpha‐Synuclein Aggregation and Improve Behavioral Symptoms in Parkinson's Disease (Adv. Mater. 51/2023) by Sela, Mor, Poley, Maria, Mora‐Raimundo, Patricia, Kagan, Shaked, Avital, Aviram, Kaduri, Maya, Chen, Gal, Adir, Omer, Rozencweig, Adi, Weiss, Yfat, Sade, Ofir, Leichtmann‐Bardoogo, Yael, Simchi, Lilach, Aga‐Mizrachi, Shlomit, Bell, Batia, Yeretz‐Peretz, Yoel, Or, Aviv Zaid, Choudhary, Ashwani, Rosh, Idan, Cordeiro, Diogo, Cohen‐Adiv, Stav, Berdichevsky, Yevgeny, Odeh, Anas, Shklover, Jeny, Shainsky‐Roitman, Janna, Schroeder, Joshua E., Hershkovitz, Dov, Hasson, Peleg, Ashkenazi, Avraham, Stern, Shani, Laviv, Tal, Ben‐Zvi, Ayal, Avital, Avi, Ashery, Uri, Maoz, Ben M., Schroeder, Avi

“…Brain‐Targeted Liposomes In article number 2304654, Avi Schroeder and co‐workers describe a targeted nanotechnology drug delivery system for treating…”
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Shank3 mutation impairs glutamate signaling and myelination in ASD mouse model and human iPSC-derived OPCs by Fischer, Inbar, Shohat, Sophie, Leichtmann-Bardoogo, Yael, Nayak, Ritu, Wiener, Gal, Rosh, Idan, Shemen, Aviram, Tripathi, Utkarsh, Rokach, May, Bar, Ela, Hussein, Yara, Castro, Ana Carolina, Chen, Gal, Soffer, Adi, Schokoroy-Trangle, Sari, Elad-Sfadia, Galit, Assaf, Yaniv, Schroeder, Avi, Monteiro, Patricia, Stern, Shani, Maoz, Ben M, Barak, Boaz

“…Autism spectrum disorder (ASD) is characterized by social and neurocognitive impairments, with mutations of the gene being prominent in patients with monogenic…”
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