Search Results - "Roses, Allen"

Pharmacogenetics in drug discovery and development: a translational perspective by Roses, Allen D

“…The association of genetic profiles to drug response is helping to expedite the development of new drugs and diagnostic tests. Roses discusses the…”
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Pharmacogenetics and drug development: the path to safer and more effective drugs by Roses, Allen D

“…Pharmacogenetics provides opportunities for informed decision-making along the pharmaceutical pipeline. There is a growing literature of retrospective studies…”
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Pharmacogenetics and the practice of medicine by Roses, Allen D

“…"If it were not for the great variability among individuals medicine might as well be a science and not an art." The thoughts of Sir William Osler in 1892…”
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CAP—advancing the evaluation of preclinical Alzheimer disease treatments by Reiman, Eric M., Langbaum, Jessica B., Tariot, Pierre N., Lopera, Francisco, Bateman, Randall J., Morris, John C., Sperling, Reisa A., Aisen, Paul S., Roses, Allen D., Welsh-Bohmer, Kathleen A., Carrillo, Maria C., Weninger, Stacie

“…The term 'preclinical Alzheimer disease (AD) treatment' refers to interventions that are initiated in cognitively unimpaired at-risk individuals, and are…”
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The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease by Larsen, Peter A, Lutz, Michael W, Hunnicutt, Kelsie E, Mihovilovic, Mirta, Saunders, Ann M, Yoder, Anne D, Roses, Allen D

“…Abstract It is hypothesized that retrotransposons have played a fundamental role in primate evolution and that enhanced neurologic retrotransposon activity in…”
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The biological foundation of the genetic association of TOMM40 with late-onset Alzheimer's disease by Zeitlow, Kahli, Charlambous, Lefko, Ng, Isaac, Gagrani, Sonal, Mihovilovic, Mirta, Luo, Shuhong, Rock, Daniel L., Saunders, Ann, Roses, Allen D., Gottschalk, W. Kirby

“…A variable-length poly-T variant in intron 6 of the TOMM40 gene, rs10524523, is associated with risk and age-of-onset of sporadic (late-onset) Alzheimer's…”
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The Medical and Economic Roles of Pipeline Pharmacogenetics: Alzheimer's Disease as a Model of Efficacy and HLA-B5701 as a Model of Safety by Roses, Allen D

“…Pharmacogenetics (PGX) is the study of drug response as a function of an individual's DNA. PGX is often viewed as an extension of disease association genetics,…”
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TOMM40′523 variant and cognitive decline in older persons with APOE ε3/3 genotype by Yu, Lei, Lutz, Michael W, Wilson, Robert S, Burns, Daniel K, Roses, Allen D, Saunders, Ann M, Gaiteri, Chris, De Jager, Philip L, Barnes, Lisa L, Bennett, David A

“…OBJECTIVE:To interrogate a poly-T variant (rs10524523, ′523) in TOMM40, a gene adjacent to the APOE gene on chromosome 19, in older persons with APOE ε3/3…”
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New applications of disease genetics and pharmacogenetics to drug development by Roses, Allen D, Saunders, Ann M, Lutz, Michael W, Zhang, Nanyin, Hariri, Ahmad R, Asin, Karen E, Crenshaw, Donna G, Budur, Kumar, Burns, Daniel K, Brannan, Stephen K

“…Highlights • A variable polyT variation within TOMM40 was associated with MCI-AD. • TOMM40 genotypes are 97% informative for estimating age of onset risk. •…”
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The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster by Subramanian, Shobana, Gottschalk, William K., Kim, So Young, Roses, Allen D., Chiba-Falek, Ornit

“…Chromosome 19q13.32 is a gene rich region, and has been implicated in multiple human phenotypes in adulthood including lipids traits, Alzheimer's disease, and…”
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Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways by Cogswell, John P, Ward, James, Taylor, Ian A, Waters, Michelle, Shi, Yunling, Cannon, Brian, Kelnar, Kevin, Kemppainen, Jon, Brown, David, Chen, Caifu, Prinjha, Rab K, Richardson, Jill C, Saunders, Ann M, Roses, Allen D, Richards, Cynthia A

“…MicroRNAs have essential functional roles in brain development and neuronal specification but their roles in neurodegenerative diseases such as Alzheimer's…”
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Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry by Scott, Laura J, Muglia, Pierandrea, Kong, Xiangyang Q, Guan, Weihua, Flickinger, Matthew, Upmanyu, Ruchi, Tozzi, Federica, Li, Jun Z, Burmeister, Margit, Absher, Devin, Thompson, Robert C, Francks, Clyde, Meng, Fan, Antoniades, Athos, Southwick, Audrey M, Schatzberg, Alan F, Bunney, William E, Barchas, Jack D, Jones, Edward G, Day, Richard, Matthews, Keith, McGuffin, Peter, Strauss, John S, Kennedy, James L, Middleton, Lefkos, Roses, Allen D, Watson, Stanley J, Vincent, John B, Myers, Richard M, Farmer, Ann E, Akil, Huda, Burns, Daniel K, Boehnke, Michael

“…Bipolar disorder (BP) is a disabling and often life-threatening disorder that affects [almost equal to]1% of the population worldwide. To identify genetic…”
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Effects of low doses of pioglitazone on resting-state functional connectivity in conscious rat brain by Crenshaw, Donna G, Asin, Karen, Gottschalk, William K, Liang, Zhifeng, Zhang, Nanyin, Roses, Allen D

“…Pioglitazone (PIO) is a peroxisome proliferator-activated receptor-γ (PPARγ) agonist in clinical use for treatment of type 2 diabetes (T2DM). Accumulating…”
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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci by Pillai, Sreekumar G, Ge, Dongliang, Zhu, Guohua, Kong, Xiangyang, Shianna, Kevin V, Need, Anna C, Feng, Sheng, Hersh, Craig P, Bakke, Per, Gulsvik, Amund, Ruppert, Andreas, Lødrup Carlsen, Karin C, Roses, Allen, Anderson, Wayne, Rennard, Stephen I, Lomas, David A, Silverman, Edwin K, Goldstein, David B

“…There is considerable variability in the susceptibility of smokers to develop chronic obstructive pulmonary disease (COPD). The only known genetic risk factor…”
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The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants by Saul, Robert, Lutz, Michael W., Burns, Daniel K., Roses, Allen D., Chiba-Falek, Ornit

“…ABSTRACT Short structural variants (SSVs) are short genomic variants (<50 bp) other than SNPs. It has been suggested that SSVs contribute to many human complex…”
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Characterization of the poly-T variant in the TOMM40 gene in diverse populations by Linnertz, Colton, Saunders, Ann M, Lutz, Michael W, Crenshaw, Donna M, Grossman, Iris, Burns, Daniel K, Whitfield, Keith E, Hauser, Michael A, McCarthy, Jeanette J, Ulmer, Megan, Allingham, Rand, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…We previously discovered that a polymorphic, deoxythymidine-homopolymer (poly-T, rs10524523) in intron 6 of the TOMM40 gene is associated with age-of-onset of…”
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Editorial overview: Molecular & genetic basis of disease by Bonini, Nancy M, Lee, Edward B, Wasco, Wilma, Roses, Allen D

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Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936 by Lyall, Donald M, Royle, Natalie A, Harris, Sarah E, Bastin, Mark E, Maniega, Susana Muñoz, Murray, Catherine, Lutz, Michael W, Saunders, Ann M, Roses, Allen D, del Valdés Hernández, Maria C, Starr, John M, Porteous, David J, Wardlaw, Joanna M, Deary, Ian J

“…The APOE ε and TOMM40 rs10524523 ('523') variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer's disease…”
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On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease by Roses, Allen D

“…The association of Apolipoprotein E-4 with the age of onset of common late-onset Alzheimer's disease (AD) was originally reported in three 1993 papers from the…”
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The cis -regulatory effect of an Alzheimer’s disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes by Linnertz, Colton, Anderson, Lauren, Gottschalk, William, Crenshaw, Donna, Lutz, Michael W, Allen, Jawara, Saith, Sunita, Mihovilovic, Mirta, Burke, James R, Welsh-Bohmer, Kathleen A, Roses, Allen D, Chiba-Falek, Ornit

“…Abstract Background We investigated the genomic region spanning the Translocase of the Outer Mitochondrial Membrane 40-kD ( TOMM40 ) and Apolipoprotein E (…”
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