Search Results - "Rosenzweig‐Lipson, S"

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression by Hughes, Z.A., Neal, S.J., Smith, D.L., Sukoff Rizzo, S.J., Pulicicchio, C.M., Lotarski, S., Lu, S., Dwyer, J.M., Brennan, J., Olsen, M., Bender, C.N., Kouranova, E., Andree, T.H., Harrison, J.E., Whiteside, G.T., Springer, D., O'Neil, S.V., Leonard, S.K., Schechter, L.E., Dunlop, J., Rosenzweig-Lipson, S., Ring, R.H.

“…Evidence suggests that 30–50% of patients suffering from major depressive disorder (MDD) are classified as suffering from treatment resistant depression (TRD)…”
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Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes by Sukoff Rizzo, S J, Neal, S J, Hughes, Z A, Beyna, M, Rosenzweig-Lipson, S, Moss, S J, Brandon, N J

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Lecozotan (SRA-333): a selective serotonin 1A receptor antagonist that enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties by Schechter, L E, Smith, D L, Rosenzweig-Lipson, S, Sukoff, S J, Dawson, L A, Marquis, K, Jones, D, Piesla, M, Andree, T, Nawoschik, S, Harder, J A, Womack, M D, Buccafusco, J, Terry, A V, Hoebel, B, Rada, P, Kelly, M, Abou-Gharbia, M, Barrett, J E, Childers, W

“…Recent data has suggested that the 5-hydroxytryptamine (5-HT)(1A) receptor is involved in cognitive processing. A novel 5-HT(1A) receptor antagonist,…”
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Opportunities for Cellular Rejuvenation in Alzheimer’s Disease: How Epigenetic Reprogramming and Chaperone-Mediated Autophagy Are Enabling Next Generation Therapeutic Approaches by Rosenzweig-Lipson, Sharon

“…Age remains the largest risk factor in the development of neurodegenerative diseases such as Alzheimer’s disease (AD). Numerous cellular hallmarks of aging…”
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Evidence for sustained elevation of IL-6 in the CNS as a key contributor of depressive-like phenotypes by Sukoff Rizzo, S J, Neal, S J, Hughes, Z A, Beyna, M, Rosenzweig-Lipson, S, Moss, S J, Brandon, N J

“…There is compelling clinical literature implicating a role for cytokines in the pathophysiology of major depressive disorder (MDD). Interleukin-6 (IL-6) and…”
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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT1A receptor antagonist and potential novel antidepressant by Beyer, CE, Lin, Q, Platt, B, Malberg, J, Hornby, G, Sullivan, KM, Smith, DL, Lock, T, Mitchell, PJ, Hatzenbuhler, NT, Evrard, DA, Harrison, BL, Magolda, R, Pangalos, MN, Schechter, LE, Rosenzweig‐Lipson, S, Andree, TH

“…Background and purpose:  As a combination of 5‐HT selective reuptake inhibitor (SSRI) with 5‐HT1A receptor antagonism may yield a rapidly acting…”
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Dopamine D1 receptor involvement in the discriminative-stimulus effects of SKF 81297 in squirrel monkeys by Rosenzweig-Lipson, S, Bergman, J

“…The discriminative-stimulus effects of the selective dopamine D1 agonist 6-chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-[1H]-3-benzazepine (SKF 81297) were…”
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Differential effects of dopamine D1 and D2 receptor agonists on schedule-controlled behavior of squirrel monkeys by Bergman, J, Rosenzweig-Lipson, S, Spealman, R D

“…The effects of dopamine agonists differing in affinity and selectivity at D1 and D2 types of dopamine receptors were compared in squirrel monkeys responding…”
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P.4.b.014 The anxiolytic-like effects of the estrogen receptor beta agonist, WAY-200070, involve activation of AMPA receptors by Hughes, Z.A, Dwyer, J.M, Pulicicchio, C.M, Rosenzweig-Lipson, S, Brandon, N.J, Liu, F

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Modification of the behavioral effects of (+/-)BAY k 8644, cocaine and d-amphetamine by L-type calcium channel blockers in squirrel monkeys by Rosenzweig-Lipson, S, Barrett, J E

“…Behavioral effects of the 1,4-dihydropyridine L-type calcium channel activator (+/-)BAY k 8644 [(+/-)methyl-1,4-dihydro-2,6-dimethyl-3-…”
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Modification of the behavioral effects of the selective dopamine D2 agonist (+)-4-propyl-9-hydroxynaphthoxazine by dopamine antagonists in monkeys by Rosenzweig-Lipson, S, Bergman, J

“…The present studies were conducted to evaluate the modification of the behavioral effects of the selective D2 agonist (+)-4-propyl-9-hydroxynaphthoxazine…”
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Preclinical characterization of WAY‐211612: a dual 5‐HT uptake inhibitor and 5‐HT 1A receptor antagonist and potential novel antidepressant by Beyer, CE, Lin, Q, Platt, B, Malberg, J, Hornby, G, Sullivan, KM, Smith, DL, Lock, T, Mitchell, PJ, Hatzenbuhler, NT, Evrard, DA, Harrison, BL, Magolda, R, Pangalos, MN, Schechter, LE, Rosenzweig‐Lipson, S, Andree, TH

“…Background and purpose:  As a combination of 5‐HT selective reuptake inhibitor (SSRI) with 5‐HT 1A receptor antagonism may yield a rapidly acting…”
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Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity by Brandt, Michael R, Cummons, Terri A, Potestio, Lisa, Sukoff, Stacey J, Rosenzweig-Lipson, Sharon

“…Perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] is a selective, competitive N-methyl-D-aspartate (NMDA)…”
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P.3.d.019 Vabicaserin: effects of a novel 5-HT2C agonist on medial prefrontal cortex neurotransmission, cognition and sensorimotor gating by Rosenzweig-Lipson, S, Beyer, C.E, Hughes, Z, Lin, Q, Zhang, M.Y, Grauer, S, Aschmies, S, Comery, T, Stack, G, Marquis, K

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Pharmacological characterization of the discriminative stimulus effects of the potassium channel blocker 4-aminopyridine in rats by Brandsgaard, R, Barrett, J E, Rosenzweig-Lipson, S

“…The discriminative stimulus (DS) effects of 4-aminopyridine (4-AP) were evaluated in 36 male Sprague-Dawley rats that were trained to discriminate 4-AP from…”
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Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments by Balu, Darrick T, Hoshaw, Brian A, Malberg, Jessica E, Rosenzweig-Lipson, Sharon, Schechter, Lee E, Lucki, Irwin

“…Abstract Antidepressant treatments have been proposed to produce their therapeutic effects, in part, through increasing neurotrophin levels in the brain. The…”
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Anxiolytic-like activity of oxytocin in male mice : behavioral and autonomic evidence, therapeutic implications by RING, Robert H, MALBERG, Jessica E, POTESTIO, Lisa, JULIA PING, BOIKESS, Steve, BIN LUO, SCHECHTER, Lee E, RIZZO, Stacey, RAHMAN, Zia, ROSENZWEIG-LIPSON, Sharon

“…Oxytocin (OT) acts as a neuromodulator/neurotransmitter within the central nervous system (CNS) and regulates a diverse range of CNS functions. Notably,…”
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Agonist efficacy and the behavioral effects of dopamine D1 receptor ligands: drug interaction studies in squirrel monkeys by Bergman, J, Spealman, R D, Madras, B K, Rosenzweig-Lipson, S

“…Dopamine agonists that reportedly differ in intrinsic activity at dopamine D1 receptors were compared for their behavioral effects in squirrel monkeys…”
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Innovative Approaches for the Development of Antidepressant Drugs: Current and Future Strategies by Schechter, Lee E., Ring, Robert H., Beyer, Chad E., Hughes, Zoë A., Khawaja, Xavier, Malberg, Jessica E., Rosenzweig-Lipson, Sharon

“…Depression is a highly debilitating disorder that has been estimated to affect up to 21% of the world population. Despite the advances in the treatment of…”
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The orphan GPCR, GPR88, modulates function of the striatal dopamine system: A possible therapeutic target for psychiatric disorders? by Logue, Sheree F., Grauer, Steven M., Paulsen, Janet, Graf, Radka, Taylor, Noel, Sung, M. Amy, Zhang, Lynn, Hughes, Zoë, Pulito, Virginia L., Liu, Feng, Rosenzweig-Lipson, Sharon, Brandon, Nicholas J., Marquis, Karen L., Bates, Brian, Pausch, Mark

“…In rodents, the orphan G protein-coupled receptor, Gpr88, is highly expressed in brain regions implicated in the pathophysiology of and is modulated by…”
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