Search Results - "Rosenwald, A"

Frequency of regulatory T cells determines the outcome of the T-cell-engaging antibody blinatumomab in patients with B-precursor ALL by Duell, J, Dittrich, M, Bedke, T, Mueller, T, Eisele, F, Rosenwald, A, Rasche, L, Hartmann, E, Dandekar, T, Einsele, H, Topp, M S

“…Blinatumomab can induce a complete haematological remission in patients in 46.6% with relapsed/refractory B-precursor acute lymphoblastic leukemia (r/r ALL)…”
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JAM-A as a prognostic factor and new therapeutic target in multiple myeloma by Solimando, A G, Brandl, A, Mattenheimer, K, Graf, C, Ritz, M, Ruckdeschel, A, Stühmer, T, Mokhtari, Z, Rudelius, M, Dotterweich, J, Bittrich, M, Desantis, V, Ebert, R, Trerotoli, P, Frassanito, M A, Rosenwald, A, Vacca, A, Einsele, H, Jakob, F, Beilhack, A

“…Cell adhesion in the multiple myeloma (MM) microenvironment has been recognized as a major mechanism of MM cell survival and the development of drug…”
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Clinical, pathological and genetic features of follicular lymphoma grade 3A: a joint analysis of the German low-grade and high-grade lymphoma study groups GLSG and DSHNHL by Koch, K., Hoster, E., Ziepert, M., Unterhalt, M., Ott, G., Rosenwald, A., Hansmann, M.L., Bernd, W., Stein, H., Pöschel, V., Dreyling, M., Trümper, L., Löffler, M., Schmitz, N., Hiddemann, W., Pfreundschuh, M., Klapper, W.

“…Histologically, follicular lymphoma (FL) grades 1, 2 and 3A are composed of two distinct cell types, centroblasts and centrocytes. FL grade 3B is composed only…”
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SPARC-positive macrophages are the superior prognostic factor in the microenvironment of diffuse large B-cell lymphoma and independent of MYC rearrangement and double-/triple-hit status by Croci, G.A., Au-Yeung, R.K.H., Reinke, S., Staiger, A.M., Koch, K., Oschlies, I., Richter, J., Poeschel, V., Held, G., Loeffler, M., Trümper, L., Rosenwald, A., Ott, G., Spang, R., Altmann, B., Ziepert, M., Klapper, W.

“…Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease with respect to outcome. Features of the tumor microenvironment (TME) are associated with…”
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133 INVITED Diffuse Large Cell Lymphoma (DLCL) by Rosenwald, A

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Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL) by Klapper, W, Stoecklein, H, Zeynalova, S, Ott, G, Kosari, F, Rosenwald, A, Loeffler, M, Trümper, L, Pfreundschuh, M, Siebert, Reiner

“…Recent retrospective studies of heterogeneously treated patients have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable…”
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CD68 expression is a discriminative feature of indolent cutaneous CD8-positive lymphoid proliferation and distinguishes this lymphoma subtype from other CD8-positive cutaneous lymphomas by Wobser, M., Roth, S., Reinartz, T., Rosenwald, A., Goebeler, M., Geissinger, E.

“…Summary Background Indolent cutaneous CD8+ lymphoid proliferation is a recently described rare entity among cutaneous T‐cell lymphomas that typically presents…”
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The diagnostic gray zone between Burkitt lymphoma and diffuse large B-cell lymphoma is also a gray zone of the mutational spectrum by Momose, S, Weißbach, S, Pischimarov, J, Nedeva, T, Bach, E, Rudelius, M, Geissinger, E, Staiger, A M, Ott, G, Rosenwald, A

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An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma by Iltzsche, F, Simon, K, Stopp, S, Pattschull, G, Francke, S, Wolter, P, Hauser, S, Murphy, D J, Garcia, P, Rosenwald, A, Gaubatz, S

“…The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in…”
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Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma by Bouska, A, Zhang, W, Gong, Q, Iqbal, J, Scuto, A, Vose, J, Ludvigsen, M, Fu, K, Weisenburger, D D, Greiner, T C, Gascoyne, R D, Rosenwald, A, Ott, G, Campo, E, Rimsza, L M, Delabie, J, Jaffe, E S, Braziel, R M, Connors, J M, Wu, C-I, Staudt, L M, D‘Amore, F, McKeithan, T W, Chan, W C

“…Follicular lymphoma (FL) is typically an indolent disease, but 30–40% of FL cases transform into an aggressive lymphoma (tFL) with a poor prognosis. To…”
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Biological characterization of adult MYC-translocation-positive mature B-cell lymphomas other than molecular Burkitt lymphoma by Aukema, Sietse M, Kreuz, Markus, Kohler, Christian W, Rosolowski, Maciej, Hasenclever, Dirk, Hummel, Michael, Küppers, Ralf, Lenze, Dido, Ott, German, Pott, Christiane, Richter, Julia, Rosenwald, Andreas, Szczepanowski, Monika, Schwaenen, Carsten, Stein, Harald, Trautmann, Heiko, Wessendorf, Swen, Trümper, Lorenz, Loeffler, Markus, Spang, Rainer, Kluin, Philip M, Klapper, Wolfram, Siebert, Reiner

“…Chromosomal translocations affecting the MYC oncogene are the biological hallmark of Burkitt lymphomas but also occur in a subset of other mature B-cell…”
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Cooperation of BRAF(F595L) and mutant HRAS in histiocytic sarcoma provides new insights into oncogenic BRAF signaling by Kordes, M, Röring, M, Heining, C, Braun, S, Hutter, B, Richter, D, Geörg, C, Scholl, C, Gröschel, S, Roth, W, Rosenwald, A, Geissinger, E, von Kalle, C, Jäger, D, Brors, B, Weichert, W, Grüllich, C, Glimm, H, Brummer, T, Fröhling, S

“…Activating BRAF mutations, in particular V600E/K, drive many cancers and are considered mutually exclusive with mutant RAS, whereas inactivating BRAF mutations…”
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Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal‐zone lymphoma with a nonclass‐switched immunoglobulin M immunophenotype by Wobser, M., Maurus, K., Roth, S., Appenzeller, S., Weyandt, G., Goebeler, M., Rosenwald, A., Geissinger, E.

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SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype by MOZOS, Ana, ROYO, Cristina, JAFFE, Elaine S, RUIZ-MARCELLAN, Carmen, DAVE, Sandeep, RIMSZA, Lisa, BRAZIEL, Rita, GASCOYNE, Randy D, SOLE, Francisco, LOPEZ-GUILLERMO, Armando, COLOMER, Dolors, STAUDT, Louis M, HARTMANN, Elena, ROSENWALD, Andreas, OTT, German, JARES, Pedro, CAMPO, Elias, DE JONG, Daphne, BARO, Cristina, VALERA, Alexandra, KAI FU, WEISENBURGER, Dennis D, DELABIE, Jan, CHUANG, Shih-Sung

“…Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of…”
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Cutaneous epithelioid haemangiomas show somatic mutations in the mitogen‐activated protein kinase pathway by Maurus, K., Kosnopfel, C., Kneitz, H., Appenzeller, S., Schrama, D., Glutsch, V., Roth, S., Gerhard‐Hartmann, E., Rosenfeldt, M., Möhrmann, L., Fröhlich, M., Hübschmann, D., Stenzinger, A., Glimm, H., Fröhling, S., Goebeler, M., Rosenwald, A., Kutzner, H., Schilling, B.

“…Summary Background Epithelioid haemangioma (EH) arising from the skin is a benign vascular tumour with marked inflammatory cell infiltration, which exhibits a…”
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Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing by Zamò, A, Pischimarov, J, Schlesner, M, Rosenstiel, P, Bomben, R, Horn, H, Grieb, T, Nedeva, T, López, C, Haake, A, Richter, J, Trümper, L, Lawerenz, C, Klapper, W, Möller, P, Hummel, M, Lenze, D, Szczepanowski, M, Flossbach, L, Schreder, M, Gattei, V, Ott, G, Siebert, R, Rosenwald, A, Leich, E

“…Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15–~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate…”
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Outcome of elderly patients with diffuse large B-cell lymphoma treated with R-CHOP: results from the UK NCRI R-CHOP14v21 trial with combined analysis of molecular characteristics with the DSHNHL RICOVER-60 trial by Kühnl, A., Cunningham, D., Counsell, N., Hawkes, E.A., Qian, W., Smith, P., Chadwick, N., Lawrie, A., Mouncey, P., Jack, A., Pocock, C., Ardeshna, K.M., Radford, J., McMillan, A., Davies, J., Turner, D., Kruger, A., Johnson, P.W., Gambell, J., Rosenwald, A., Ott, G., Horn, H., Ziepert, M., Pfreundschuh, M., Linch, D.

“…There is an on-going debate whether 2- or 3-weekly administration of R-CHOP is the preferred first-line treatment for elderly patients with diffuse large…”
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Genomic alterations and gene expression in primary diffuse large B-cell lymphomas of immune-privileged sites: the importance of apoptosis and immunomodulatory pathways by Booman, M, Szuhai, K, Rosenwald, A, Hartmann, E, Kluin-Nelemans, HC, de Jong, D, Schuuring, E, Kluin, PM

“…Primary diffuse large B-cell lymphomas of different immune-privileged sites (IP-DLBCLs) share many clinical and biological features, such as a relatively poor…”
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Similar clinical features in follicular lymphomas with and without breaks in the BCL2 locus by Leich, E, Hoster, E, Wartenberg, M, Unterhalt, M, Siebert, R, Koch, K, Klapper, W, Engelhard, M, Puppe, B, Horn, H, Staiger, A M, Stuhlmann-Laeisz, C, Bernd, H W, Feller, A C, Hummel, M, Lenze, D, Stein, H, Hartmann, S, Hansmann, M L, Möller, P, Hiddemann, W, Dreyling, M, Ott, G, Rosenwald, A

“…Approximately 15% of follicular lymphomas (FLs) lack breaks in the BCL2 locus. The aim of this study was to better define molecular and clinical features of…”
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Follicular lymphoma grade 3B is a distinct neoplasm according to cytogenetic and immunohistochemical profiles by HORN, Heike, SCHMELTER, Christopher, OTT, German, LEICH, Ellen, SALAVERRIA, Itziar, KATZENBERGER, Tiemo, MICHAELA OTT, M, KALLA, Jörg, ROMERO, Monica, SIEBERT, Reiner, ROSENWALD, Andreas

“…According to the current World Health Organization Classification of Lymphoid Tumours, follicular lymphoma is subclassified into three grades according to the…”
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